Protein recognition of macrocycles: Binding of anti-HIV metallocyclams to lysozyme

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 7, 2005, Pages 2288-2292

  Hunter, Tina M ^a   McNae, Iain W ^a   Liang, Xiangyang ^a   Bella, Juraj ^a   Parsons, Simon ^a   Walkinshaw, Malcolm D ^a   Sadler, Peter J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Copper; CXCR4 coreceptor; NMR; X ray crystallography; Zinc

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); AMINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ASPARTIC ACID; CARBONYL DERIVATIVE; CARBOXYLIC ACID; CHEMOKINE RECEPTOR CXCR4; COORDINATION COMPOUND; COPPER DERIVATIVE; COPPER ION; CYCLAM DERIVATIVE; G PROTEIN COUPLED RECEPTOR; GLYCINE; INDOLE; LYSOZYME; MACROCYCLIC COMPOUND; METAL DERIVATIVE; NICKEL; OXYGEN; TRYPTOPHAN; ZINC ION;

ARTICLE; BINDING AFFINITY; BINDING SITE; CIS ISOMER; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STEREOSPECIFICITY; TRANS ISOMER; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-HIV AGENTS; BINDING SITES; CHICKENS; CRYSTALLOGRAPHY, X-RAY; HETEROCYCLIC COMPOUNDS; HUMANS; LACTAMS, MACROCYCLIC; METALS; MODELS, MOLECULAR; MURAMIDASE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; RECEPTORS, CXCR4;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 14044266994     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0407595102     Document Type: Article

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