Selective recognition of configurational substates of zinc cyclam by carboxylates: Implications for the design and mechanism of action of anti-HIV agents

Chemistry - A European Journal

Volumn 9, Issue 19, 2003, Pages 4709-4717

  Liang, Xiangyang ^a   Weishäupl, Michael ^a   Parkinson, John A ^a   Parsons, Simon ^a   McGregor, Pamela A ^a   Sadler, Peter J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Anti HIV activity; Cyclam; NMR spectroscopy; X ray diffraction; Zinc

Indexed keywords

COMPLEXATION; CRYSTALLINE MATERIALS; HYDROGEN BONDS; METHANOL; SYNTHESIS (CHEMICAL);

LIGANDS;

VIRUSES;

ACETIC ACID; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARBOXYLIC ACID DERIVATIVE; CHEMOKINE RECEPTOR CXCR4; CHLORIDE; COORDINATION COMPOUND; CYCLAM DERIVATIVE; LIGAND; METHANOL; OXYGEN; PERCHLORATE; PHTHALIC ACID; ZINC DERIVATIVE;

ANTIVIRAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; COMPLEX FORMATION; CONFORMATION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG MECHANISM; HYDROGEN BOND; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLID STATE; TITRIMETRY; X RAY DIFFRACTION;

ANTI-HIV AGENTS; CARBOXYLIC ACIDS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HETEROCYCLIC COMPOUNDS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; TEMPERATURE; ZINC;

EID: 0142087795     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/chem.200304808     Document Type: Article

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