Transcutaneous penetration of toluene in rat skin a microdialysis study

Experimental Dermatology

Volumn 14, Issue 2, 2005, Pages 103-108

  Klede, Monika ^a   Schmitz, Harald ^a   Göen, Thomas ^b   Fartasch, Manigé ^a   Drexler, Hans ^a   Schmelz, Martin ^c  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Barrier creams; Cutaneous absorption; Skin barrier function; Solvent; Tape stripping

Indexed keywords

COSMETIC; TOLUENE;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DIALYSATE; FLAME PHOTOMETRY; GAS CHROMATOGRAPHY; MALE; MEMBRANE PERMEABILITY; MICRODIALYSIS; NONHUMAN; RAT; SKIN BLOOD FLOW; SKIN PENETRATION; SKIN SURFACE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADMINISTRATION, CUTANEOUS; ANIMALS; IN SITU NICK-END LABELING; KINETICS; MALE; MICRODIALYSIS; RATS; RATS, WISTAR; SKIN; SKIN ABSORPTION; SKIN PHYSIOLOGY; TIME FACTORS; TOLUENE; VASODILATOR AGENTS;

EID: 14044253555     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0906-6705.2005.00227.x     Document Type: Article

References (39)

1. Inoue O, Seiji K, Watanabe T, et al. Effects of smoking and drinking habits on urinary o-cresol excretion after occupational exposure to toluene vapor among Chinese workers. Am J Ind Med 1994: 25: 697-708.
2. Poulson S R, Drever J I, Colberg P J. Estimation of Koc values for deuterated benzene, toluene, and ethylbenzene, and application to ground water contamination studies. Chemosphere 1997: 35: 2215-2224.
3. Boman A, Maibach H I. Influence of evaporation and solvent mixtures on the absorption of toluene and N-butanol in human skin in vitro. Ann Occup Hyg 2000: 44: 125-135.
4. Kanikkannan N, Patel R, Jackson T, Shaik M S, Singh M. Percutaneous absorption and skin irritation of JP-8 (jet fuel). Toxicology 2001: 161: 1-11.
5. Pierce C H, Dills R L, Morgan M S, Vicini P, Kalman D A. Biological monitoring of controlled toluene exposure. Int Arch Occup Environ Health 1998: 71: 433-444.
6. Hruska K S, Furth P A, Seifer D B, Sharara F I , Flaws J A. Environmental factors in infertility. Clin Obstet Gynecol 2000: 43: 821-829.
7. Pierce C H, Chen Y, Dills R L, Kalman D A, Morgan M S. Toluene metabolites as biological indicators of exposure. Toxicol Lett 2002: 129: 65-76.
8. Kanikkannan N, Kandimalla K, Lamba S S, Singh M. Structure-activity relationship of chemical penetration enhancers in transdermal drug delivery. Curr Med Chem 2000: 7: 593-608.
9. Wiechers J W. The barrier function of the skin in relation to percutaneous absorption of drugs. Pharm Weekbl [Sci] 1989: 11: 185-198.
10. Boelsma E, Anderson C, Karlsson A M, Ponec M. Microdialysis technique as a method to study the percutaneous penetration of methyl nicotinate through excised human skin, reconstructed epidermis, and human skin in vivo [In Process Citation]. Pharm Res 2000: 17: 141-147.
11. Boutsiouki P, Thompson J P, Clough G F. Effects of local blood flow on the percutaneous absorption of the organophosphorus compound malathion: a microdialysis study in man. Arch Toxicol 2001: 75: 321-328.
12. Oberthur C, Heinemann C, Elsner P, Benfeldt E, Hamburger M. A comparative study on the skin penetration of pure tryptanthrin and tryptanthrin in Isatis tinctoria extract by dermal microdialysis coupled with isotope dilution ESI-LC-MS. Planta Med 2003: 69: 385-389.
13. Simonsen L, Jorgensen A, Benfeldt E, Groth L. Differentiated in vivo skin penetration of salicylic compounds in hairless rats measured by cutaneous microdialysis. Eur J Pharm Sci 2004: 21: 379-388.
14. Groth L. Cutaneous microdialysis - a new technique for the assessment of skin penetration. Curr Probl Dermatol 1998: 26: 90-98.
15. Benfeldt E. In vivo microdialysis for the investigation of drug levels in the dermis and the effect of barrier perturbation on cutaneous drug penetration. Studies in hairless rats and human subjects. Acta Derm Venereol Suppl (Stockh) 1999: 206: 1-59.
16. Benfeldt E, Serup J. Effect of barrier perturbation on cutaneous penetration of salicylic acid in hairless rats: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function. Arch Dermatol Res 1999: 291: 517-526.
17. Benfeldt E, Serup J, Menne T. Effect of barrier perturbation on cutaneous salicylic acid penetration in human skin: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function. Br J Dermatol 1999: 140: 739-748.
18. Morgan C J, Renwick A G, Friedmann P S. The role of stratum corneum and dermal microvascular perfusion in penetration and tissue levels of water-soluble drugs investigated by microdialysis. Br J Dermatol 2003: 148: 434-443.
19. Carneheim C, Stahle L. Microdialysis of lipophilic compounds: a methodological study. Pharmacol Toxicol 1991: 69: 378-380.
20. Lehmann B, Sauter W, Knuschke P, Dressler S, Meurer M. Demonstration of UVB-induced synthesis of 1 alpha, 25-dihydroxyvitamin D3 (calcitriol) in human skin by microdialysis. Arch Dermatol Res 2003: 295: 24-28.
21. Leveque N, Muret P, Mary S, et al. Validation of a microdialysis-gas chromatographic-mass spectrometric method to assess 8-methoxypsoralen in psoriatic patient dermis. J Chromatogr B Anal Technol Biomed Life Sci 2002: 780: 119-127.
22. Pierce C H, Dills R L, Morgan M S, Nothstein G L, Shen D D, Kalman D A. Interindividual differences in 2H8-toluene toxicokinetics assessed by semiempirical physiologically based model. Toxicol Appl Pharmacol 1996: 139: 49-61.
23. Kezic S, Monster A C, van de Grevel I A, Kruse J, Opdam J J, Verberk M M. Dermal absorption of neat liquid solvents on brief exposures in volunteers. AIHAJ 2001: 62: 12-18.
24. VanRooij J G, De Roos J H, Bodelier-Bade M M, Jongeneelen F J. Absorption of polycyclic aromatic hydrocarbons through human skin: differences between anatomical sites and individuals. J Toxicol Environ Health 1993: 38: 355-368.
25. Cavalieri E, Rogan E. Role of radical cations in aromatic hydrocarbon carcinogenesis. Environ Health Perspect 1985: 64: 69-84.
26. Meguro S, Arai Y, Masukawa Y, Uie K, Tokimitsu I. Relationship between covalently bound ceramides and transepidermal water loss (TEWL). Arch Dermatol Res 2000: 292: 463-468.
27. Tsai J C, Sheu H M, Hung P L, Cheng C L. Effect of barrier disruption by acetone treatment on the permeability of compounds with various lipophilicities: implications for the permeability of compromised skin. J Pharm Sci 2001: 90: 1242-1254.
28. Wu P C, Chang J S, Huang Y B, Chai C Y, Tsai Yh. Evaluation of percutaneous absorption and skin irritation of ketoprofen through rat skin: in vitro and in vivo study. Int J Pharm 2001: 222: 225-235.
29. Clough G F, Boutsiouki P, Church M K, Michel C C. Effects of blood flow on the in vivo recovery of a small diffusible molecule by microdialysis in human skin. J Pharmacol Exp Ther 2002: 302: 681-686.
30. Schnetz E, Diepgen T L, Elsner P, et al. Multicentre study for the development of an in vivo model to evaluate the influence of topical formulations on irritation. Contact Dermatitis 2000: 42: 336-343.
31. Frosch P J, Schulze-Dirks A, Hoffmann M, Axthelm I, Kurte A. Efficacy of skin barrier creams (I). The repetitive irritation test (RIT) in the guinea pig. Contact Dermatitis 1993: 28: 94-100.
32. Wigger-Alberti W, Rougier A, Richard A, Elsner P. Efficacy of protective creams in a modified repeated irritation test. Methodological aspects. Acta Derm Venereol 1998: 78: 270-273.
33. Zhai H, Maibach H I. Percutaneous penetration (dermatopharmacokinetics) in evaluating barrier creams. Curr Probl Dermatol 1996: 25: 193-205.
34. Loden M, Andersson A C, Lindberg M. Improvement in skin barrier function in patients with atopic dermatitis after treatment with a moisturizing cream (Canoderm). Br J Dermatol 1999: 140: 264-267.
35. Frosch P J, Schulze-Dirks A, Hoffmann M, Axthelm I. Efficacy of skin barrier creams (II). Ineffectiveness of a popular 'skin protector' against various irritants in the repetitive irritation test in the guinea pig. Contact Dermatitis 1993: 29: 74-77.
36. Bettinger J, Gloor M, Peter C, Kleesz P, Fluhr J, Gehring W. Opposing effects of glycerol on the protective function of the horny layer against irritants and on the penetration of hexyl nicotinate. Dermatology 1998: 197: 18-24.
37. Szycher M. Recent advances in transdermal delivery systems. J Biomater Appl 1986: 1: 207-238.
38. Kalinin A, Marekov L N, Steinert P M. Assembly of the epidermal cornified cell envelope. J Cell Sci 2001: 114: 3069-3070.
39. Marjukka S T, Bouwstra J A, Urtti A. Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations. J Control Release 1999: 59: 149-161.