Evaluation of percutaneous absorption and skin irritation of ketoprofen through rat skin: In vitro and in vivo study

International Journal of Pharmaceutics

Volumn 222, Issue 2, 2001, Pages 225-235

  Wu, Pao Chu ^a   Chang, Jin Sheng ^a   Huang, Yaw Bin ^a   Chai, Chee Yin ^a   Tsai, Yi Hung ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Azone; Colorimetry; Irritation; Ketoprofen; Nonivamide

Indexed keywords

ALCOHOL; FORMAX PLUS; KETOPROFEN; LAUROCAPRAM; MENTHOL; NONIVAMIDE; PENETRATION ENHANCING AGENT;

ANIMAL TISSUE; ARTICLE; BIOPSY; COLORIMETRY; CONTROLLED STUDY; DRUG EFFECT; DRUG FORMULATION; DRUG MECHANISM; DRUG PENETRATION; DRUG RESEARCH; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN ABSORPTION; SKIN IRRITATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; COLORIMETRY; GELS; HALF-LIFE; KETOPROFEN; MALE; RATS; RATS, WISTAR; SKIN; SKIN ABSORPTION;

EID: 0035902673     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00707-4     Document Type: Article

References (33)

1. Penetration enhancers in human skin-effect of oleic acid and azone on flurbiprofen permeation
2. Quantitative skin blanching assay for corticosteroid creams using tristimulus colour analysis
3. The effect of azone and capsaicin on the permeation of naproxen through human skin
4. In vitro permeation study of capsaicin and its synthetic derivatives from ointment bases using various skin types
5. Percutaneous absorption and skin erythema: Quantification of capsaicin and its sunthetic derivatives from gels incorporated with benzalkonium chloride by using non-invasive bioengineering methods
6. Topical EMLA® pre-treatment fails to decrease the pain induced by 1% topical capsaicin
7. Capsaicin and nociception in the rat and mouse
8. A pharmacokinetic model for percutaneous absorption
9. The effects of a series of capsaicin analogues on nociception and body temperature in the rat
10. Effect of azone on the percutaneous absorption of 5-flurouracil from gels in hairless rats
11. The effect of pretreatment by penetration enhancers on the in vivo percutaneous absorption of Piroxicam from its gel form in rabbits
12. Effect of the administration of ketoprofen gel on the percutaneous absorption of ketoprofen in rabbits
13. Crude drug (Zingiberaceae) enhancement of percutaneous absorption of indomethacin: In vitro and in vivo permeation
14. Clinical pharmacokinetics of ketoprofen and its enantiomers
15. Analysis of the combined effect of I-menthol and ethanol as skin permeation enhancers bases on a two-layer skin model
16. Ketoprofen: A review of its pharmacologic and clinical properties
17. Different patterns of hyperalgesia induced by experimental inflammation in human skin
18. Antinociceptive action of capsaicin in rofents
19. Dose-dependent enhancement effects of azone on skin permeability
20. A new enhancer-coenhancer system to increase skin permeation of morphine hydrochloride in vitro
21. Percutaneous absorption of indomethacin from ointment bases in rabbits
22. Photoelectric quantitative evaluation of argon laser treatment of port wine stains
23. Pharmacological studies on cutaneous inflammation induced by ultraviolet irradiation (1): Quantification of erythema by reflectance colorimetry and correlation with cutaneous blood flow
24. Effect of synthesized cyclohexanol derivatives using L-menthol as a lead compound on the percutaneous absorption of ketoprofen
25. A pharmacokinetic model for the percutaneous absorption of indomethacin and the predication of drug disposition kinetics
26. A comparison of the carrageenan edema test and ultraviolet light-induced erythema test as presictors of the clinical dose in rheumatoid arthritis
27. Dihydroxyacetone test as a substitute for the dansyl chloride test
28. Sensory effects of capsaicin congeners part 1: Relationship between chemical structure and pain-producing potency of pungent agent
29. Simultaneous optimization for several characteristics concerning percutaneous absorption and skin damage of ketoprofen hydrogels containing d-linomene
30. Quantification of UV-induced erythema with a portable computer controlled chromameter
31. Terpenes and the lipid-protein partitioning theory of skin penetration enhancement
32. Vehicle effects on topical drug delivery. III. Effect of azone on the cutaneous permeation of metronidazole and propylene glycol
33. Percutaneous absorption of captopril from hydrophilic cellulose gel® through excised rabbit skin and human skin