Effects of in utero and lactational exposure to flutamide in SD rats: Comparison of the effects of administration periods

Toxicology

Volumn 209, Issue 1, 2005, Pages 47-54

  Yamasaki, Kanji ^a   Noda, Shuji ^a   Muroi, Takako ^a   Mitoma, Hideo ^a   Takakura, Saori ^a   Sakamoto, Satoko ^a  

^a CHEMICALS EVALUATION AND RESEARCH INSTITUTE   (Japan)

Author keywords

Anti androgen effect; Endocrine; Flutamide; In utero and lactational exposure; Rat

Indexed keywords

FLUTAMIDE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONGENITAL MALFORMATION; CONTROLLED STUDY; FEMALE; GESTATION PERIOD; LACTATION; MALE; NEWBORN MORTALITY; NONHUMAN; PERINATAL PERIOD; PRENATAL DRUG EXPOSURE; PREPUCE; PRIORITY JOURNAL; PROGENY; RAT; REPRODUCTION; STATISTICAL ANALYSIS; STILLBIRTH; TESTOSTERONE BLOOD LEVEL; WEANING;

EID: 13944257688     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.12.004     Document Type: Article

References (32)

1. J. Buelke-Sam, I.R. Cohen, D. Wierda, K.I. Griffey, L.F. Fisher, and P.C. Francis The selective estrogen receptor modulator, raloxifene: a segment II/III delivery study in rats Reprod. Toxicol. 12 1998 271 288
2. G.M. Cooke, H. Tryphonas, O. Pulido, D. Caldwell, G.S. Bondy, and D. Forsyth Oral (gavage), in utero and postnatal exposure of Sprague-Dawley rats to low doses of tributyltin chloride. Part 1. Toxicology, histopathology and clinical chemistry Food Chem. Toxicol. 42 2004 211 220
3. I. Goddard, A. Florin, C. Mauduit, E. Tabone, P. Contard, R. Bars, F. Chuzel, and M. Benahmed Alteration of lactate production and transport in the adult rat testis exposed in utero to flutamide Mol. Cell. Endocrinol. 206 2003 137 146
4. L.E. Gray, J.S. Ostby, and W.R. Lelce Developmental effects of an environmental anti-androgen: the fungicide vinclozolin alters sex differentiation of the male rat Toxicol. Appl. Pharmacol. 129 1994 46 52
5. R. Haraguchi, R. Mo, C. Hui, J. Motoyama, S. Makino, T. Shiroishi, W. Gaffield, and G. Yamada Unique functions of Sonic hedgehog signaling during external genitalia development Development 128 2001 4241 4250
6. R. Haraguchi, K. Suzuki, R. Murakami, M. Sakai, M. Kamikawa, M. Kengaku, K. Sekine, H. Kawano, S. Kato, N. Ueno, and G. Yamada Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation Development 127 2000 2471 2479
7. J. Imperato-McGinley, R.S. Sanchez, J.R. Spencer, B. Yee, and E.D. Vaughan Comparison of the effects of the 5 alpha-reductase inhibitor finasteride and the anti-androgen flutamide on prostate and genital differentiation: dose-response studies Endocrinology 131 1992 1149 1156
8. K.S. Kang, J.H. Che, and Y.S. Lee Lack of adverse effects in the F1 offspring maternally exposed to genistein at human intake dose level Food Chem. Toxicol. 40 2002 43 51
9. K. Kobayashi, M. Miyagawa, R.S. Wang, S. Sekiguchi, M. Suda, and T. Honma Effects of in utero and lactational exposure to bisphenol A on somatic growth and anogenital distance in F1 rat offspring Ind. Health 40 2002 375 381
10. T. Kunimatsu, T. Yamada, K. Miyata, S. Yabusita, T. Seki, Y. Okuno, and M. Matsuo Evaluation for reliability and feasibility of the draft protocol for enhanced rat 28-day subacute study (OECD Guideline 407) using androgen antagonist flutamide Toxicology 15 2004 77 89
11. B.S. McIntyre, N.J. Barlow, and P.M. Foster Androgen-mediated development in male rat offspring exposed flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues Toxicol. Sci. 62 2001 236 249
12. J.A. McLachlan Functional toxicology: a new approach to detect functionally active xenobiotics Environ. Health Perspect. 101 1993 386 387
13. J.A. McLachlan, and K.S. Korach Estrogens in the environment global health implications Environ. Health Perspect. 103 Suppl. 7 1995 3 4
14. K. Miyata, S. Yabushita, T. Sukata, M. Sano, H. Yoshino, T. Nakanishi, Y. Okuno, and M. Matsuo Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats J. Toxicol. Sci. 27 2002 19 33
15. R.W. Moore, T.A. Rudy, T.M. Lin, K. Ko, and R.E. Peterson Abnormalities of sexual development in male rats with in utero and lactational exposure to the anti-androgenic plasticizer Di(2-ethylhexyl) phthalate Environ. Health Perspect. 109 2001 229 237
16. E. Mylchreest, M. Sar, R.C. Cattley, and P.M. Foster Disruption of androgen-regulated male reproductive development by Di(n-butyl) phthalate during late gestation in rats is different from flutamide Toxicol. Appl. Pharmacol. 156 1999 81 95
17. E. Mylchreest, D.G. Wallace, R.C. Cattley, and P.M. Foster Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl)phthalate during late gestation Toxicol. Sci. 55 2000 143 151
18. T. Nagao, R. Ohta, H. Marumo, T. Shindo, S. Yoshimura, and H. Ono Effect of butyl benzyl phthalate in Sprague-Dawley rats after gavage administration: a two-generation reproductive study Reprod. Toxicol. 14 2000 513 532
19. A. Omezzine, S. Chater, C. Mauduit, A. Florin, E. Tabone, F. Chuzel, R. Bars, and M. Benahmed Long-term apoptotic cell death process with increased expression and activation of caspase-3 and -6 in adult rat germ cells exposed in utero to flutamide Endocrinology 144 2003 648 661
20. Organisation for Economic Cooperation and Development (OECD), 1998. Report of the first meeting of the OECD endocrine disrupter testing and assessment (EDTA) working group.
21. Organisation for Economic Cooperation and Development (OECD), 2000. The second meeting of the OECD validation management group (VMG) for the screening and testing of endocrine disrupters.
22. Organisation for Economic Cooperation and Development (OECD), 2003. The fourth meeting of the OECD validation management group (VMG) for the screening and testing of endocrine disrupters.
23. M. Sawaki, S. Noda, T. Muroi, H. Mitoma, S. Takakura, S. Sakamoto, and K. Yamasaki In utero through lactational exposure to ethynil estradiol induced cleft phallus and delayed ovarian dysfunction in the offspring Toxicol. Sci. 75 2003 402 411
24. J.H. Shin, H.S. Kim, H.J. Moon, H. Kang, T.S. Kim, J.H. Seok, I.Y. Kim, K.L. Park, S.Y. Han, and S.Y. Nam Effects of flutamide on pubertal in male rats: an evaluation of the protocol for the assessment of pubertal development and thyroid function J. Toxicol. Environ. Health 65 2002 433 445
25. T.E. Stoker, S.C. Laws, D.L. Guidici, and R.L. Cooper The effect of atrazine on puberty in male Wistar rats: an evaluation in the protocol for the assessment of pubertal development and thyroid function Toxicol. Sci. 58 2000 50 59
26. K.J. Turner, N.J. Barlow, M.F. Struve, D.G. Wallace, K.W. Gaido, D.C. Dorman, and P.M. Foster Effects of in utero exposure to the organophosphate insecticide fenitrothion on androgen-dependent reproductive development in the Crl:CD(SD)BR rat Toxicol. Sci. 68 2002 174 183
27. C.J. Wolf, A. Hotchkiss, J.S. Ostby, G.A. LeBlanc, and L.E. Gray Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response study Toxicol. Sci. 65 2002 71 86
28. W.P. Weisenburger, A.R. Hagler, and M.S. Tassinari Pre- postnatal development studies of lasofoxifene, selective estrogen receptor modulator (SERM), in Sprague-Dawley rats Birth Defects Res. Part B Dev. Reprod. Toxicol. 71 2004 171 184
29. A.B. Wisniewski, S.L. Klein, Y. Lakshmanan, and J.P. Gearhart Exposure to genistein during gestation and lactation demasculinizes the reproductive system in rats J. Urol. 169 2003 1582 1586
30. K. Yamasaki, M. Takeyoshi, Y. Yakabe, M. Sawaki, M. Imatanaka, K. Shinoda, and M. Takatsuki Immature rat uterotrophic assay of 18 chemicals and Hershberger assay of 30 chemicals Toxicology 183 2003 95 115
31. L. You, M. Casanova, E.J. Bartolucci, M.W. Fryczynski, D.C. Dorman, J.L. Everit, K.W. Gaido, S.M. Ross, and H.H. Heck Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor Toxicol. Sci. 66 2002 91 104
32. L. You, M. Casanova, S. Archibeque-Engle, M. Sar, L.Q. Fan, and H.A. Heck Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally p,p′-DDE Toxicol. Sci. 45 1998 162 173