Synthesis and antiproliferative activity of unsaturated quinoline derivatives

Anti-Cancer Drug Design

Volumn 15, Issue 3, 2000, Pages 171-181

  Montgomery, G J ^a   McKeown, P ^a   McGown, A T ^a   Robins, D J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Antiproliferative activity; Knoevenagel condensation; Protein tyrosine kinases; Tyrphostins

Indexed keywords

2 CYANO 3 (QUINOLIN 6 YL)PROPENENITRILE; 2 CYANO 3 (QUINOLIN 7YL)PROPENAMIDE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; ETHYL 2 CYANO 3 (QUINOLIN 7 YL)PROPENOATE; MALONONITRILE; PROTEIN TYROSINE KINASE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHILICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL DIVISION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMAN; PHOSPHORYLATION; QUINOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED; TYRPHOSTINS;

EID: 0033808790     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Synthesis and antiproliferative activity of tyrphostins containing heteroaromatic moieties
2. Synthesis and biological activity of a series of tyrphostins containing nitrothiophene moieties as possible epidermal growth factor receptor tyrosine kinase inhibitors
3. Synthesis and antiproliferative activity of tyrphostins containing quinoline moieties
4. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
5. Two step redox systems
6. Phosphorylation of synthetic peptides by a protein tyrosine kinase from the particulate fraction of a lymphoma cell line
7. New applications of malononitrile in organic chemistry
8. Tyrphostins I. Synthesis and biological evaluation of protein tyrosine kinase inhibitors
9. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and erbB2/neu tyrosine kinases
10. Tyrphostins. 3. Structure-activity relationship studies of a substituted benzylidenemalononitrile 5-S-aryltyrphostins
11. Syntheses with nitriles. Part 43
12. Synthesis of structural ananlogs of leukotriene B4 and their receptor binding activity
13. Inhibitors of tyrosine kinase
14. Over-expression of the EGF receptor-related proto-oncogene erbB2 in human mammary tumour cell lines by different molecular mechanisms
15. Bryostatin 1-tamoxifen combinations show synergistic effects in the inhibition of the growth of P388 cells in vitro
16. Molecular recognition of carbohydrates by zinc porphyrins: Lewis acid/Lewis base combinations as a dominant factor for their selectivity
17. Synthesis of quinoline aldehydes
18. Alkaloids of Nitraria komarovii. 7. Structure and synthesis of komarovinine
19. Tyrosine kinase inhibitors