FOXP2 in focus: What can genes tell us about speech and language?

Trends in Cognitive Sciences

Volumn 7, Issue 6, 2003, Pages 257-262

  Marcus, Gary F ^a   Fisher, Simon E ^b  

^a NEW YORK UNIVERSITY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABILITY TESTING; BEHAVIORAL RESEARCH; BRAIN; SPEECH;

SPOKEN LANGUAGES;

GENES;

PROTEIN; PROTEIN FOX P2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG;

AUTOSOMAL DOMINANT INHERITANCE; BRAIN; CHROMOSOME REARRANGEMENT; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LINKAGE GROUP; GENE MUTATION; GENE SEQUENCE; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HEART; HUMAN; INTELLIGENCE QUOTIENT; INTESTINE; LANGUAGE DEVELOPMENT; LINGUISTICS; LUNG; MENTAL DEFICIENCY; NERVE TRACT; REVIEW; SPEECH DEVELOPMENT;

EID: 0038202901     PISSN: 13646613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1364-6613(03)00104-9     Document Type: Review

References (38)

1. King M.C., Wilson A.C. Evolution at two levels in humans and chimpanzees. Science. 188:1975;107-116.
2. Ebersberger I. Genomewide comparison of DNA sequences between humans and chimpanzees. Am. J. Hum. Genet. 70:2002;1490-1497.
3. Hayes K.J., Nissen C.H. Higher mental functions of a home-raised chimpanzee. Schrier A.M., Stollnitz F. Behaviour of Non-human Primates. 1971;59-115 Academic Press, New York.
4. Terrace H.S., et al. Can an ape create a sentence? Science. 206:1979;891-902.
5. Goldin-Meadow S., Feldman H. The development of language-like communication without a language model. Science. 197:1977;401-403.
6. Goldin-Meadow S., Mylander C. Spontaneous sign systems created by deaf children in two cultures. Nature. 391:1998;279-281.
7. Senghas A., Coppola M. Children creating language: how Nicaraguan sign language acquired a spatial grammar. Psychol Sci. 12:2001;323-328.
8. Pinker S. The Language Instinct. 1994;Allen Lane.
9. Fitch W.T. The evolution of speech: a comparative review. Trends Cogn. Sci. 4:2000;258-267.
10. Lai C.S.L., et al. A novel forkhead-domain gene is mutated in a severe speech and language disorder. Nature. 413:2001;519-523.
11. Fisher S.E., et al. Deciphering the genetic basis of speech and language disorders. Annu. Rev. Neurosci. 26:2003;57-80.
12. Hurst J.A., et al. An extended family with a dominantly inherited speech disorder. Dev. Med. Child Neurol. 32:1990;352-355.
13. Fisher S.E., et al. Localisation of a gene implicated in a severe speech and language disorder. Nat. Genet. 18:1998;168-170.
14. Lai C.S.L., et al. The SPCH1 region on human 7q31: genomic characterization of the critical interval and localization of translocations associated with speech and language disorder. Am. J. Hum. Genet. 67:2000;357-368.
15. Gopnik M. Feature-blind grammar and dysphasia. Nature. 344:1990;715.
16. Gopnik M., Crago M.B. Familial aggregation of a developmental language disorder. Cognition. 39:1991;1-50.
17. Vargha-Khadem F., Passingham R.E. Speech and language defects. Nature. 346:1990;226.
18. Vargha-Khadem F., et al. Praxic and nonverbal cognitive deficits in a large family with a genetically transmitted speech and language disorder. Proc. Natl. Acad. Sci. U. S. A. 92:1995;930-933.
19. Vargha-Khadem F., et al. Neural basis of an inherited speech and language disorder. Proc. Natl. Acad. Sci. U. S. A. 95:1998;12695-12700.
20. Alcock K.J., et al. Oral dyspraxia in inherited speech and language impairment and acquired dysphasia. Brain Lang. 75:2000;17-33.
21. Watkins K.E., et al. Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia. Brain. 125:2002;452-464.
22. Carlsson P., Mahlapuu M. Forkhead transcription factors: key players in development and metabolism. Dev. Biol. 250:2002;1-23.
23. Gehring W.J., Ikeo K. Pax 6: mastering eye morphogenesis and eye evolution. Trends Genet. 15:1999;371-377.
24. Simpson T.I., Price D.J. Pax6; a pleiotropic player in development. Bioessays. 24:2002;1041-1051.
25. Halder G., et al. Induction of ectopic eyes by target expression of the eyeless gene in Drosophila. Science. 267:1995;1788-1792.
26. Shu W., et al. Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J. Biol. Chem. 276:2001;27488-27497.
27. Enard W., et al. Molecular evolution of FOXP2, a gene involved in speech and language. Nature. 418:2002;869-872.
28. Jacob F. Evolution and tinkering. Science. 196:1977;1161-1166.
29. Gerhart J., Kirschner M. Cells, Embryos, and Evolution. 1997;Blackwell Science.
30. Zhang J., et al. Accelerated protein evolution and origins of human-specific Features. Foxp2 as an example. Genetics. 162:2002;1825-1835.
31. Boyd R., Silk J.B. How Humans Evolved. 2000;W.W. Norton, New York.
32. Klein R.G., Edgar B. The Dawn of Human Culture. 2002;Wiley, New York.
33. Watkins K.E., et al. MRI analysis of an inherited speech and language disorder: structural brain abnormalities. Brain. 125:2002;465-478.
34. Liegois, F.J. et al. (2002) Functional abnormalities associated with the FOXP2 (SPCH1) mutation in the KE family: an overt speech FMRI study. Soc. Neurosci. Abstr. Program No. 17.12. (Abstract Viewer, online).
35. Newbury D.F., et al. FOXP2 is not a major susceptibility gene for autism or specific language impairment. Am. J. Hum. Genet. 70:2002;1318-1327.
36. Fisher S.E., DeFries J.C. Developmental dyslexia: genetic dissection of a complex cognitive trait. Nat. Rev. Neurosci. 3:2002;767-780.
37. Weigel D., et al. The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo. Cell. 57:1989;645-658.
38. Nishimura D.Y., et al. A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye. Am. J. Hum. Genet. 68:2001;364-372.