Differential effects of the organochlorine pesticide DDT and its metabolite p,p′-DDE on p-glycoprotein activity and expression

Toxicology and Applied Pharmacology

Volumn 203, Issue 2, 2005, Pages 91-98

  Shabbir, Arsalan ^a   DiStasio, Susan ^a   Zhao, Jingbo ^a,b   Cardozo, Christopher P ^a,b   Wolff, Mary S ^a   Caplan, Avrom J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

DDT; Organochlorine pesticide; p,p DDE; p Glycoprotein

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; CHAPERONE; CHLORPHENOTANE; DIMETHYL SULFOXIDE; FLUORESCENT DYE; GLUCOSE REGULATED PROTEIN 78; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; MULTIDRUG RESISTANCE PROTEIN 1; RHODAMINE 123; RIFAMPICIN; VERAPAMIL; XENOBIOTIC AGENT;

ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL SPECIFICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEFENSE MECHANISM; EXPOSURE; FEMALE; GENDER; GENETIC CODE; HELA CELL; HUMAN; HUMAN CELL; LIVER; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRESS; TOXICITY;

ANIMALIA; TRIXIS;

EID: 13844253394     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.07.011     Document Type: Article

References (23)

1. L.J. Bain, and G.A. LeBlanc Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein Toxicol. Appl. Pharmacol. 141 1996 288 298
2. P. Borst, and R.O. Elferink Mammalian ABC transporters in health and disease Annu. Rev. Biochem. 71 2002 537 592
3. S. Chu, A. Covaci, W. Jacobs, K. Haraguchi, and P. Schepens Distribution of methyl sulfone metabolites of polychlorinated biphenyls and p,p′-DDE in human tissues Environ. Health Perspect. 111 2003 1222 1227
4. S. Chu, A. Covaci, and P. Schepens Levels and chiral signatures of persistent organochlorine pollutants in human tissues from Belgium Environ. Res. 93 2003 167 176
5. J.L. Davis, R.O. Morris, and I.J. Tinsley Quantitative measurement of microsomal subfractions isolated from livers of rats fed with 1,1,1-trichloro-2,2-bis (p-chlorophenyl ethane (DDT) Biochem. Pharmacol. 22 1973 869 877
6. N.A. Eufemia, and D. Epel Induction of the multixenobiotic defense mechanism (MXR), P-glycoprotein, in the mussel Mytilus californianus as a general cellular response to environmental stresses Aquat. Toxicol. 49 2000 89 100
7. A. Geick, M. Eichelbaum, and O. Burk Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin J. Biol. Chem. 276 2001 14581 14587
8. B. Goodwin, M.R. Redinbo, and S.A. Kliewer Regulation of cyp3a gene transcription by the pregnane X receptor Annu. Rev. Pharmacol. Toxicol. 42 2002 1 23
9. K. Jaga, and C. Dharmani Global surveillance of DDT and DDE levels in human tissues Int. J. Occup. Med. Environ. Health 16 2003 7 20
10. R.J. Kaufman Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls Genes Dev. 13 1999 1211 1233
11. W.R. Kelce, C.R. Stone, S.C. Laws, L.E. Gray, J.A. Kemppainen, and E.M. Wilson Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist Nature 375 1995 581 585
12. S.A. Kliewer, J.T. Moore, L. Wade, J.L. Staudinger, M.A. Watson, S.A. Jones, D.D. McKee, B.B. Oliver, T.M. Willson, R.H. Zetterstrom, T. Perlmann, and J.M. Lehmann An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway Cell 92 1998 73 82
13. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 25 2001 402 408
14. M.P. Longnecker, W.J. Rogan, and G. Lucier The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBS (polychlorinated biphenyls) and an overview of organochlorines in public health Annu. Rev. Public Health 18 1997 211 244
15. L. Salphati, and L.Z. Benet Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers Biochem. Pharmacol. 55 1998 387 395
16. T.W. Synold, I. Dussault, and B.M. Forman The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux Nat. Med. 7 2001 584 590
17. N.M. Tampal, L.W. Robertson, C. Srinivasan, and G. Ludewig Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1 Toxicol. Appl. Pharmacol. 187 2003 168 177
18. B. Tan, D. Piwnica-Worms, and L. Ratner Multidrug resistance transporters and modulation Curr. Opin. Oncol. 12 2000 450 458
19. V. Turusov, V. Rakitsky, and L. Tomatis Dichlorodiphenyltrichloroethane (DDT): ubiquity, persistence, and risks Environ. Health Perspect. 110 2002 125 128
20. C.S. Williams, and R.A. Chung Ultrastructural effects of DDT on cells grown in vitro J. Environ. Pathol., Toxicol. Oncol. 7 1987 35 58
21. M.S. Wolff, P.G. Toniolo, E.W. Lee, M. Rivera, and N. Dubin Blood levels of organochlorine residues and risk of breast cancer J. Natl. Cancer Inst. 85 1993 648 652
22. M.E. Wyde, E. Bartolucci, A. Ueda, H. Zhang, B. Yan, M. Negishi, and L. You The environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor Mol. Pharmacol. 64 2003 474 481
23. W. Xie, and R.M. Evans Orphan nuclear receptors: the exotics of xenobiotics J. Biol. Chem. 276 2001 37739 37742