Development of an oral exposure mouse model to predict drug-induced hypersensitivity reactions by using reporter antigens

Toxicological Sciences

Volumn 83, Issue 2, 2005, Pages 273-281

  Nierkens, Stefan ^a   Aalbers, Marloes ^a   Bol, Marianne ^a   van Wijk, Femke ^a   Hassing, Ine ^a   Pieters, Raymond ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Antibodies; Drug induced hypersensitivity; Mouse model; Oral; Relevant route; Reporter antigen

Indexed keywords

ANTIGEN; DICLOFENAC; FICOLL; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; NEVIRAPINE; OVALBUMIN; PENICILLAMINE; TRINITROPHENYL;

ALLERGENICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; BYSTANDER EFFECT; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; DOSE RESPONSE; DRUG EXPOSURE; DRUG HYPERSENSITIVITY; DRUG SCREENING; DRUG SENSITIZATION; FEMALE; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; METABOLIC REGULATION; MOUSE; NONHUMAN; PREDICTION; RISK ASSESSMENT; T LYMPHOCYTE;

ADMINISTRATION, ORAL; ALLERGENS; ANIMALS; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; DISEASE MODELS, ANIMAL; DRUG HYPERSENSITIVITY; FEMALE; FICOLL; IMMUNOLOGIC MEMORY; INJECTIONS, INTRAPERITONEAL; LYMPH NODES; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; OVALBUMIN; PREDICTIVE VALUE OF TESTS;

EID: 13644251921     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi021     Document Type: Article

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