BALB/c mice orally pretreated with diclofenac have augmented and accelerated PLNA responses to diclofenac

Toxicology

Volumn 172, Issue 3, 2002, Pages 217-230

  Gutting, Bradford W ^a   Updyke, Lawrence W ^a   Amacher, David E ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

D penicillamine; Diclofenac; Drug hypersensitivity; PLNA; Popliteal lymph node assay; Reporter antigen; Streptozotocin; T cell dependent; TNP Ficoll; Trinitrophenyl Ficoll

Indexed keywords

DICLOFENAC; DRUG VEHICLE; FICOLL; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; PENICILLAMINE; PICRIC ACID; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCING CELL; ANTIBODY PRODUCTION; ARTICLE; ASSAY; CELL INFILTRATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; FEMALE; HYPERSENSITIVITY REACTION; IMMUNOSTIMULATION; LYMPH NODE; MOUSE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ALKALINE PHOSPHATASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FEMALE; FICOLL; IMMUNITY, CELLULAR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INDICATORS AND REAGENTS; LYMPH NODES; MICE; MICE, INBRED BALB C; ORGAN SIZE; TIME FACTORS;

EID: 0037006910     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00008-2     Document Type: Article

References (40)

1. Evaluation of allergenic potential of low-molecular compounds by mouse popliteal lymph node assay
2. The use of reporter antigens in the popliteal lymph node assay to assess immunomodulation by chemicals
3. 2 and diphenylhydantoin stimulate IgG production to TNP-Ficoll and TNP-OVA, supporting and extending the graft-versus-host hypothesis for chemical induction of autoimmunity
4. Clinical immunotoxicity of antirheumatic drugs
5. Predictive immunological test systems: Suitability of the popliteal lymph node assay in mice and rats
6. Idiosyncratic liver toxicity of nonsteroidal antiinflammatory drugs: Molecular mechanisms and pathology
7. Sensitivity to a metabolite of diclofenac as a cause of acute immune hemolytic anemia
8. Morphology of popliteal lymph node responses in Brown-Norway rats
9. Value of animal models for predicting hypersensitivity reactions to medicinal products
10. Common allergic and allergic-like reactions to medications: When the cure becomes the curse
11. The popliteal lymph node assay in 1996
12. Popliteal lymph node assay
13. Allergic reactions to drugs and biological agents
14. Drug allergy
15. T cell-dependent immune reactions to reactive benzene metabolites in mice
16. The popliteal lymph node assay (PLNA) in rodents: A simple functional test for detecting sensitizing effects of xenobiotics
17. T cell-dependent B-cell proliferation and activation induced by administration of the drug diphenylhydantoin to mice
18. Studies on the mechanism of drug sensitization: T-cell-dependent popliteal lymph node reaction to diphenylhydantoin
19. Phagocytes render chemicals immunogenic: Oxidation of gold (I) to the T cell sensitizing gold (III) metabolite generated by mononuclear phagocytes
20. Allergic and autoimmune reactions to xenobiotics: How do they arise?
21. Differential responses of B cells from the spleen and lymph node to TNP-Ficoll
22. Drug allergies
23. A comparison of the direct and reporter antigen popliteal lymph node assay for the detection of immunomodulation by low molecular weight compounds
24. Pre-clinical methods for detecting the hypersensitivity potential of pharmaceuticals: Regulatory considerations
25. Immunity to D-penicillamine: Genetic, cellular, and chemical requirements for induction of popliteal lymph node enlargement in the mouse
26. Specific immunity to streptozotocin: Cellular requirements for induction of lymphoproliferation
27. Th1/Th2 responses to drugs
28. B-lymphocyte responses to trinitrophenyl-conjugated Ficoll: Requirements for T lymphocytes and Ia-bearing adherent cells
29. Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injury
30. Adverse reactions to nonsteroidal anti-inflammatory drugs: Diclofenac compared with other nonsteroidal anti-inflammatory drugs
31. The popliteal lymph node assay: A tool for predicting drug allergies
32. Delayed hypersensitivity to diclofenac: A report on two cases
33. Diclofenac-induced immune haemolytic anaemia: Simultaneous occurrence of red blood cell autoantibodies and drug-dependent antibodies
34. The functional role of CD8+ T helper type 2 cells
35. Review of diclofenac and evaluation of its place in therapy as a nonsteroidal antiinflammatory agent
36. Enhancement by monoclonal anti-LYB-2 antibody of antigen-specific B lymphocyte expansion stimulated by TNP-Ficoll and T lymphocyte-derived factors
37. Popliteal lymph node reactions in mice induced by the drug zimeldine
38. Drug-associated anaphylaxis: 20 years of reporting in the Netherlands (1974-1994) and review of the literature
39. T cells ignore the parent drug propylthiouracil but are sensitized to a reactive metabolite generated in vivo
40. T cell reaction against aniline metabolites and their endogenous formation in mononuclear phagocytes