Prolonged inflammatory response to acute pseudomonas challenge in interleukin-10 knockout mice

American Journal of Respiratory and Critical Care Medicine

Volumn 165, Issue 8, 2002, Pages 1176-1181

  Chmiel, James F ^a   Konstan, Michael W ^a   Saadane, Aicha ^a   Krenicky, Jeanne E ^a   Lester Kirchner, H ^a   Berger, Melvin ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Cystic fibrosis; Inflammation; Interleukin 10; Lung; Pseudomonas aeruginosa

Indexed keywords

CYTOKINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; GRAM NEGATIVE INFECTION; INFLAMMATION; KNOCKOUT MOUSE; LUNG LAVAGE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

EID: 0037090469     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.165.8.2107051     Document Type: Article

References (30)

1. Cystic fibrosis: State of the art
2. Early pulmonary inflammation in infants with cystic fibrosis
3. Altered respiratory epithelial cell cytokine production in cystic fibrosis
4. Current understanding of the inflammatory process in cystic fibrosis: Onset and etiology
5. Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis
6. Activation of NF-κB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells
7. Inflammatory cytokines in cystic fibrosis lungs
8. Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis
9. Distinct sputum cytokine profiles in cystic fibrosis and other chronic inflammatory airway disease
10. Reduced IL-10 secretion by CD4+ T lymphocytes expressing mutant cystic fibrosis transmembrane conductance regulator (CFTR)
11. Defects in cystic fibrosis transmembrane regulator (CFTR) alter epithelial cell cytokine production
12. Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
13. Interleukin 10 (IL-10) regulation of tumor necrosis factor α (TNF-α) from human alveolar macrophages and peripheral blood monocytes
14. Regulation of human alveolar macrophage inflammatory cytokine production by interleukin-10
15. Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes: Evidence for an autocrine role of tumor necrosis factor and IL-1β in mediating the production of IL-8 triggered by lipopolysaccharide
16. Regulation of neutrophil-derived chemokine expression by IL-10
17. In vivo suppression of NF-κB and preservation of IκBα by interleukin-10 and interleukin-13
18. Interleukin-10 signaling blocks inhibitor of κB kinase activity and nuclear factor κB DNA binding
19. IL-10 enhances resolution of pulmonary inflammation in vivo by promoting apoptosis of neutrophils
20. Interleukin-10-deficient mice develop chronic enterocolitis
21. Murine models of CF airway inflammation
22. A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues
23. The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis
24. IL-10 attenuates excessive inflammation in chronic Pseudomonas infection in mice
25. Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa
26. A rat model of chronic respiratory infection with Pseudomonas aeruginosa
27. Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection: Implications for antiinflammatory therapy in cystic fibrosis
28. Microbial pathogenesis in cystic fibrosis: Pulmonary clearance of mucoid Pseudomonas aeruginosa and inflammation in a mouse model of repeated respiratory challenge
29. IL-10 improves lung injury and survival in Pseudomonas aeruginosa pneumonia
30. Interleukin-10 impairs host defense in murine pneumococcal pneumonia