Acute oxygen sensing in cellular models: Relevance to the physiology of pulmonary neuroepithelial and carotid bodies

Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology

Volumn 270, Issue 1, 2003, Pages 41-50

  Kemp, Paul J ^a   Searle, Gavin J ^a   Hartness, Matthew E ^a   Lewis, Anthony ^a   Miller, Paula ^a   Williams, Sandile ^a   Wootton, Phillippa ^a   Adriaensen, Dirk ^b   Peers, Chris ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Hypoxia; Potassium channel; Tandem P domain

Indexed keywords

ARTERIAL OXYGEN TENSION; CAROTID BODY; CELL FUNCTION; CELL IMMORTALIZATION; CELL STRUCTURE; CHEMOSENSITIVITY; CONFERENCE PAPER; HOMEOSTASIS; HUMAN; MODEL; NEUROEPITHELIAL BODY; NEUROSECRETORY CELL; NONHUMAN; PRIORITY JOURNAL; SENSOR; SIGNAL TRANSDUCTION;

EID: 0141919823     PISSN: 0003276X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ar.a.10008     Document Type: Conference Paper

References (42)

1. Adriaensen D, Timmermans JP, Brouns I, Berthoud HR, Neuhuber WL, Scheuermann DW. 1998. Pulmonary intraepithelial vagal nodose afferent nerve terminals are confined to neuroepithelial bodies: an anterograde tracing and confocal microscopy study in adult rats. Cell Tissue Res 293:395-405.
2. Adriaensen D, Scheuermann DW, Gajda M, Brouns I, Timmermans JP. 2001. Functional implications of extensive new data on the innervation of pulmonary neuroepithelial bodies. Ital J Anat Embryol 106:395-403.
3. - channel alpha- and beta-subunits in HEK293 cells. FEBS Lett 415:67-70.
4. phox subunit of NADPH oxidase. Proc Natl Acad Sci USA 96:7944-7949.
5. 3 receptors. Am J Respir Cell Mol Biol 23:52-61.
6. Brouns I, Van Nassauw L, Van Genechten J, Majewski M, Scheuermann DW, Timmermans JP, Adriaensen D. 2002. Triple immunofluorescence staining with antibodies raised in the same species to study the complex innervation pattern of intrapulmonary chemoreceptors. J Histochem Cytochem 50:575-582.
7. Buckler KJ, Williams BA, Honore E. 2000. An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells. J Physiol 525:135-142.
8. Chandel NS, Schumacker PT. 2000. Cellular oxygen sensing by mitochondria: old questions, new insights. J Appl Physiol 88:1880-1889.
9. Colebrooke RL, Smith IF, Kemp PJ, Peers C. 2002. Calcium channel remodelling by chronic hypoxia in a human airway chemoceptor cell line. Neurosci Lett 318:69-72.
10. Cutz E, Gillan JE, Track NS. 1984. Pulmonary endocrine cells in the developing human lung and during neonatal adaptation. In: Becker KL, Gazdar AF, editors. The endocrine lung in health and disease. Philadelphia: W.B. Saunders. p 210-231.
11. Cutz E, Jackson A. 1999. Neuroepithelial bodies as airway oxygen sensors. Respir Physiol 115:201-214.
12. Fu XW, Nurse C, Wang YT, Cutz E. 1999. Selective modulation of membrane currents by hypoxia in intact airway chemoreceptors from neonatal rabbit. J Physiol 514:139-150.
13. + current modulation in wild type and oxidase-deficient mice. Proc Natl Acad Sci USA 97:4374-4379.
14. Fu XW, Nurse CA, Wong V, Cutz E. 2002. Hypoxia-induced secretion of serotonin from intact pulmonary neuroepithelial bodies in neonatal rabbit. J Physiol 539:503-510.
15. Gazdar AF, Helman LJ, Israel MA, Russell EK, Linnoila RI, Mulshine JL, Schuller HM, Park JG. 1988. Expression of neuro-endocrine cell markers L-DOPA decarboxylase, chromogranin-A, and dense core granules in human-tumors of endocrine and nonendocrine origin. Cancer Res 48:4078-4082.
16. Gillan JE, Curran C, O'Rielly E, Cahalane SF, Unwin AR. 1989. Abnormal patterns of pulmonary neuroendocrine cells in victims of sudden infant death syndrome. Paediatrics 84:828-834.
17. Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N. 2001. Potassium leak channels and the KCNK family of two-P-domain subunits. Nat Rev Neurosci 2:175-184.
18. + channel. J Biol Chem 276:26499-26508.
19. Lauweryns JM, Cokelaere M. 1973. Hypoxia-sensitive neuro-epithelial bodies. Intrapulmonary secretory neuroreceptors, modulated by the CNS. Z Zellforsch Mikrosk Anat 145:521-540.
20. Lauweryns JM, Cokeleare M, Lerut T, Theunynck P. 1978. Cross-circulation studies on the influence of hypoxia and hypoxaemia on neuroepithelial bodies in young rabbits. Cell Tissue Res 193:373-386.
21. Leach RM, Hill HM, Snetkov VA, Robertson TP, Ward JP. 2001. Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor. J Physiol 536:211-224.
22. + channel. Biochem Biophys Res Commun 285:1290-1294.
23. 2--sensitive. J Physiol 540:771-780.
24. Lipton AJ, Johnson MA, Macdonald T, Lieberman MW, Gozal D, Gaston B. 2001. S-nitrosothiols signal the ventilatory response to hypoxia. Nature 413:171-174.
25. 2 in type I chemoreceptor cells. Science 241:580-582.
26. + channels in neuroepithelial body-derived small cell carcinoma cells of the human lung. Am J Physiol 275:L709-L716.
27. + current in a human neuroepithelial body-derived cell line. Am J Physiol 276:L96-L104.
28. 2 sensing by airway chemoreceptor-derived cells: protein kinase C activation reveals functional evidence for involvement of NADPH oxidase. J Biol Chem 275:7684-7692.
29. 2-sensing in model airway chemoreceptor cells. Biochem Biophys Res Commun 283:1131-1134.
30. Pancrazio JJ, Viglione MP, Tabbara IA, Kim YI. 1989. Voltage-dependent ion channels in small-cell lung cancer cells. Cancer Res 49:5901-5906.
31. Patel AJ, Honore E. 2001. Molecular physiology of oxygen-sensitive potassium channels. Eur Respir J 18:221-227.
32. Peers C, Buckler KJ. 1995. Transduction of chemostimuli by the type I carotid body cell. J Membr Biol 144:1-9.
33. Peers C, Kemp PJ. 2001. Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors. Respir Res 2:145-149.
34. i and respiratory responses to hypoxia. Brain Res 872:188-193.
35. 2 sensing in model airway chemoreceptors. Biochem Biophys Res Commun 291:332-337.
36. + channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines. Proc Natl Acad Sci USA 93:13182-13187.
37. Ward JP, Aaronson PI. 1999. Mechanisms of hypoxic pulmonary vasoconstriction: can anyone be right? Respir Physiol 115:261-271.
38. Waypa GB, Chandel NS, Schumacker PT. 2001. Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ Res 88:1259-1266.
39. Weir EK, Archer SL. 1995. The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J 9:183-189.
40. Youngson C, Nurse C, Yeger H, Cutz E. 1993. Oxygen sensing in airway chemoreceptors. Nature 365:153-155.
41. Youngson C, Nurse C, Yeger H, Cutz E. 1994. Characterization of membrane currents in pulmonary neuroepithelial bodies: hypoxia-sensitive airway chemoreceptors. In: O'Regan RG, Nolan P, McQueen DS, Paterson DJ, editors. Arterial chemoreceptors. Cell to system. New York and London: Plenum Press. p 179-182.
42. Zhong H, Zhang M, Nurse CA. 1997. Synapse formation and hypoxic signalling in co-cultures of rat petrosal neurones and carotid body type 1 cells. J Physiol 503:599-612.