In vitro inhibitory effects of non-steroidal antiinflammatory drugs on UDP-glucuronosyltransferase 1A1-catalysed estradiol 3β -glucuronidation in human liver microsomes

Biopharmaceutics and Drug Disposition

Volumn 26, Issue 1, 2005, Pages 35-39

  Mano, Yuji ^a   Usui, Takashi ^a   Kamimura, Hidetaka ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Estradiol; Human liver microsomes; Inhibition; NSAID; UGT1A1

Indexed keywords

DICLOFENAC; DIFLUNISAL; ESTRADIOL; GLUCURONOSYLTRANSFERASE 1A1; HYMECROMONE; INDOMETACIN; KETOPROFEN; NAPROXEN; NIFLUMIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG GLUCURONIDATION; DRUG POTENCY; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY; INHIBITION KINETICS; LIVER MICROSOME;

ACETAMINOPHEN; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; DRUG EVALUATION, PRECLINICAL; ESTRADIOL; ESTRADIOL ANTAGONISTS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; INHIBITORY CONCENTRATION 50; MICROSOMES, LIVER; NAPROXEN;

EID: 13444266538     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.430     Document Type: Article

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