Characterization of rat and human UDP-glucuronosyltransferases responsible for the in Vitro glucuronidation of diclofenac

Toxicological Sciences

Volumn 61, Issue 1, 2001, Pages 49-53

  King, C ^a   Tang, W ^a   Ngui, J ^a   Tephly, T ^b   Braun, M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Acyl glucuronides; Diclofenac; Glucuronidation; NSAIDs; UGTs

Indexed keywords

DICLOFENAC; GLUCURONOSYLTRANSFERASE; IBUPROFEN; ISOPROTEIN; KETOPROFEN; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT ENZYME; TOLMETIN; ZOMEPIRAC;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; DRUG GLUCURONIDATION; DRUG INHIBITION; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME SUBSTRATE; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIVER MICROSOME; MALE; NONHUMAN; RAT; SAMPLE;

ANIMALS; CATALYSIS; CHROMATOGRAPHY, LIQUID; DICLOFENAC; ENZYME INHIBITORS; FEMALE; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; ISOENZYMES; KINETICS; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; MORPHINE; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; STATISTICS; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0035038561     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/61.1.49     Document Type: Article

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