Narrative review: Celiac disease: Understanding a complex autoimmune disorder

Annals of Internal Medicine

Volumn 142, Issue 4, 2005, Pages 289-298

  Alaedini, Armin ^a   Green, Peter H R ^b  

^a Department of Obstetrics Gynecology   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BIOCHEMICAL MARKER; GLUTEN; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; VEGETABLE PROTEIN;

AUTOIMMUNE DISEASE; BARLEY; BLOOD ANALYSIS; CANCER; CELIAC DISEASE; CLINICAL FEATURE; DERMATITIS HERPETIFORMIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC ERROR; DISEASE ASSOCIATION; ENDOCRINE DISEASE; GENETIC ASSOCIATION; HUMAN; HYPERPLASIA; IMMUNOSTIMULATION; INTESTINE VILLUS ATROPHY; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW; RYE;

EID: 13444252375     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-142-4-200502150-00011     Document Type: Review

References (122)

1. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology. 2001;120:636-51.
2. Green PH, Jabri B. Coeliac disease. Lancet. 2003;362:383-91.
3. Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003;163:286-92.
4. Tommasini A, Not T, Kiren V, Baldas V, Santon D, Trevisiol C, et al. Mass screening for coeliac disease using antihuman transglutaminase antibody assay. Arch Dis Child. 2004;89:512-5.
5. Bingley PJ, Williams AJ, Norcross AJ, Unsworth DJ, Lock RJ, Ness AR, et al. Undiagnosed coeliac disease at age seven: population based prospective birth cohort study. BMJ. 2004;328:322-3.
6. Maki M, Mustalahti K, Kokkonen J, Kulmala P, Haapalahti M, Karttunen T, et al. Prevalence of Celiac disease among children in Finland. N Engl J Med. 2003;348:2517-24.
7. Greco L, Romino R, Coto I, Di Cosmo N, Percopo S, Maglio M, et al. The first large population based twin study of coeliac disease. Gut. 2002;50:624-8.
8. Howell MD, Austin RK, Kelleher D, Nepom GT, Kagnoff MF. An HLA-D region restriction fragment length polymorphism associated with celiac disease. J Exp Med. 1986;164:333-8.
9. Sollid LM, Markussen G, Ek J, Gjerde H, Vartdal F, Thorsby E. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. J Exp Med. 1989;169:345-50.
10. Molberg O, Solheim Flaete N, Jensen T, Lundin KE, Arentz-Hansen H, Anderson OD, et al. Intestinal T-cell responses to high-molecular-weight glutenins in celiac disease. Gastroenterology. 2003;125:337-44.
11. Bao F, Yu L, Babu S, Wang T, Hoffenberg EJ, Rewers M, et al. One third of HLA DQ2 homozygous patients with type 1 diabetes express celiac disease-associated transglutaminase autoantibodies. J Autoimmun. 1999;13:143-8.
12. Lampasona V, Bonfanti R, Bazzigaluppi E, Venerando A, Chiumello G, Bosi E, et al. Antibodies to tissue transglutaminase C in type I diabetes. Diabetologia. 1999;42:1195-8.
13. Collin P, Kaukinen K, Valimaki M, Salmi J. Endocrinological disorders and celiac disease. Endocr Rev. 2002;23:464-83.
14. Mainardi E, Montanelli A, Dotti M, Nano R, Moscato G. Thyroid-related autoantibodies and celiac disease: a role for a gluten-free diet? J Clin Gastroenterol. 2002;35:245-8.
15. O'Leary C, Walsh CH, Wieneke P, O'Regan P, Buckley B, O'Halloran DJ, et al. Coeliac disease and autoimmune Addison's disease: a clinical pitfall. QJM. 2002;95:79-82.
16. Rostami K, Steegers EA, Wong WY, Braat DD, Steegers-Theunissen RP. Coeliac disease and reproductive disorders: a neglected association. Eur J Obstet Gynecol Reprod Biol. 2001;96:146-9.
17. Meloni GF, Dessole S, Vargiu N, Tomasi PA, Musumeci S. The prevalence of coeliac disease in infertility. Hum Reprod. 1999;14:2759-61.
18. Corazza GR, Andreani ML, Venturo N, Bernardi M, Tosti A, Gasbarrini G. Celiac disease and alopecia areata: report of a new association. Gastroenterology. 1995;109:1333-7.
19. Hadjivassiliou M, Grunewald RA, Davies-Jones GA. Idiopathic cerebellar ataxia associated with celiac disease: lack of distinctive neurological features [Letter]. J Neurol Neurosurg Psychiatry. 1999;67:257.
20. Bushara KO, Goebel SU, Shill H, Goldfarb LG, Hallett M. Gluten sensitivity in sporadic and hereditary cerebellar ataxia. Ann Neurol. 2001;49:540-3.
21. Shill HA, Alaedini A, Latov N, Hallett M. Anti-ganglioside antibodies in idiopathic and hereditary cerebellar degeneration. Neurology. 2003;60:1672-3.
22. Alaedini A, Green PH, Sander HW, Hays AP, Gamboa ET, Fasano A, et al. Ganglioside reactive antibodies in the neuropathy associated with celiac disease. J Neuroimmunol. 2002;127:145-8.
23. Luostarinen L, Himanen SL, Luostarinen M, Collin P, Pirttila T. Neuromuscular and sensory disturbances in patients with well treated coeliac disease. J Neurol Neurosurg Psychiatry. 2003;74:490-4.
24. Chin RL, Sander HW, Brannagan TH, Green PH, Hays AP, Alaedini A, et al. Celiac neuropathy. Neurology. 2003;60:1581-5.
25. Luostarinen L, Dastidar P, Collin P, Peraaho M, Maki M, Erila T, et al. Association between coeliac disease, epilepsy and brain atrophy. Eur Neurol. 2001;46:187-91.
26. Gabrielli M, Cremonini F, Fiore G, Addolorato G, Padalino C, Candelli M, et al. Association between migraine and Celiac disease: results from a preliminary case-control and therapeutic study. Am J Gastroenterol. 2003;98:625-9.
27. Curione M, Barbato M, De Biase L, Viola F, Lo Russo L, Cardi E. Prevalence of coeliac disease in idiopathic dilated cardiomyopathy [Letter]. Lancet. 1999;354:222-3.
28. Frustaci A, Cuoco L, Chimenti C, Pieroni M, Fioravanti G, Gentiloni N, et al. Celiac disease associated with autoimmune myocarditis. Circulation. 2002;105:2611-8.
29. Gillett HR, Cauch-Dudek K, Jenny E, Heathcote EJ, Freeman HJ. Prevalence of IgA antibodies to endomysium and tissue transglutaminase in primary biliary cirrhosis. Can J Gastroenterol. 2000;14:672-5.
30. Sjoberg K, Lindgren S, Eriksson S. Frequent occurrence of non-specific gliadin antibodies in chronic liver disease. Endomysial but not gliadin antibodies predict coeliac disease in patients with chronic liver disease. Scand J Gastroenterol. 1997;32:1162-7.
31. Volta U, De Franceschi L, Molinaro N, Cassani F, Muratori L, Lenzi M, et al. Frequency and significance of anti-gliadin and anti-endomysial antibodies in autoimmune hepatitis. Dig Dis Sci. 1998;43:2190-5.
32. Davison S. Coeliac disease and liver dysfunction. Arch Dis Child. 2002;87:293-6.
33. Ransford RA, Hayes M, Palmer M, Hall MJ. A controlled, prospective screening study of celiac disease presenting as iron deficiency anemia. J Clin Gastroenterol. 2002;35:228-33.
34. Kemppainen T, Kroger H, Janatuinen E, Arnala I, Kosma VM, Pikkarainen P, et al. Osteoporosis in adult patients with celiac disease. Bone. 1999;24:249-55.
35. Cataldo F, Marino V, Ventura A, Bottaro G, Corazza GR. Prevalence and clinical features of selective immunoglobulin A deficiency in coeliac disease: an Italian multicentre study. Italian Society of Paediatric Gastroenterology and Hepatology (SIGEP) and "Club del Tenue" Working Groups on Coeliac Disease. Gut. 1998;42:362-5.
36. Iltanen S, Collin P, Korpela M, Holm K, Partanen J, Polvi A, et al. Celiac disease and markers of celiac disease latency in patients with primary Sjogren's syndrome. Am J Gastroenterol. 1999;94:1042-6.
37. Lepore L, Martelossi S, Pennesi M, Falcini F, Ermini ML, Ferrari R, et al. Prevalence of celiac disease in patients with juvenile chronic arthritis. J Pediatr. 1996;129:311-3.
38. Bonamico M, Pasquino AM, Mariani P, Danesi HM, Culasso F, Mazzanti L, et al. Prevalence and clinical picture of celiac disease in Turner syndrome. J Clin Endocrinol Metab. 2002;87:5495-8.
39. Agardh D, Nilsson A, Carlsson A, Kockum I, Lernmark A, Ivarsson SA. Tissue transglutaminase autoantibodies and human leucocyte antigen in Down's syndrome patients with coeliac disease. Acta Paediatr. 2002;91:34-8.
40. Ventura A, Martelossi S. Dental enamel defects and coeliac disease [Letter]. Arch Dis Child. 1997;77:91.
41. Aine L, Maki M, Collin P, Keyrilainen O. Dental enamel defects in celiac disease. J Oral Pathol Med. 1990;19:241-5.
42. Lo W, Sano K, Lebwohl B, Diamond B, Green PH. Changing presentation of adult celiac disease. Dig Dis Sci. 2003;48:395-8.
43. Murray JA, Van Dyke C, Plevak MF, Dierkhising RA, Zinsmeister AR, Melton LJ 3rd. Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001. Clin Gastroenterol Hepatol. 2003;1:19-27.
44. Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child. 1990;65:909-11.
45. NIH Consensus Development Conference Statement: Celiac Disease. 2004. Accessed at http://consensus.nih.gov/cons/118/118celiacPDF.pdf on 30 September 2004.
46. Hurlstone DP, Sanders DS. High-magnification immersion chromoscopic duodenoscopy permits visualization of patchy atrophy in celiac disease: an opportunity to target biopsies of abnormal mucosa [Letter]. Gastrointest Endosc. 2003;58:815-6.
47. Siegel LM, Stevens PD, Lightdale CJ, Green PH, Goodman S, Garcia-Carrasquillo RJ, et al. Combined magnification endoscopy with chromoendoscopy in the evaluation of patients with suspected malabsorption. Gastrointest Endosc. 1997;46:226-30.
48. Scott BB, Losowsky MS. Patchiness and duodenal-jejunal variation of the mucosal abnormality in coeliac disease and dermatitis herpetiformis. Gut. 1976;17:984-92.
49. Bonamico M, Mariani P, Thanasi E, Ferri M, Nenna R, Tiberti C, et al. Patchy villous atrophy of the duodenum in childhood celiac disease. J Pediatr Gastroenterol Nutr. 2004;38:204-7.
50. Dandalides SM, Carey WD, Petras R, Achkar E. Endoscopic small bowel mucosal biopsy: a controlled trial evaluating forceps size and biopsy location in the diagnosis of normal and abnormal mucosal architecture. Gastrointest Endosc. 1989;35:197-200.
51. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology. 1992;102:330-54.
52. Sategna-Guidetti C, Grosso S, Bruno M, Grosso SB. Reliability of immunologic markers of celiac sprue in the assessment of mucosal recovery after gluten withdrawal. J Clin Gastroenterol. 1996;23:101-4.
53. Tursi A, Brandimarte G, Giorgetti GM. Lack of usefulness of anti-transglutaminase antibodies in assessing histologic recovery after gluten-free diet in celiac disease. J Clin Gastroenterol. 2003;37:387-91.
54. Sbarbati A, Valletta E, Bertini M, Cipolli M, Morroni M, Pinelli L, et al. Gluten sensitivity and 'normal' histology: is the intestinal mucosa really normal? Dig Liver Dis. 2003;35:768-73.
55. Dewar D, Pereira SP, Ciclitira PJ. The pathogenesis of coeliac disease. Int J Biochem Cell Biol. 2004;36:17-24.
56. Rostom A, Dube C, Cranney A, Saloojee N, Sy R, Garritty C, et al. Celiac disease. Evidence Report/Technology Assessment No. 104. Rockville, MD: Agency for Healthcare Research and Quality; 2004. AHRQ publication no. 04-E029-2.
57. Thompson T. Oats and the gluten-free diet. J Am Diet Assoc. 2003;103:376-9.
58. Arentz-Hansen H, Fleckenstein B, Molberg O, et al. The molecular basis for oat intolerance in patients with celiac disease. Plos Med. 2004;1:e1.
59. Thompson T. Gluten contamination of commercial oat products in the United States [Letter]. N Engl J Med. 2004;351:2021-2.
60. Abdulkarim AS, Burgart LJ, See J, Murray JA. Etiology of nonresponsive celiac disease: results of a systematic approach. Am J Gastroenterol. 2002;97:2016-21.
61. Culliford AN, Green PH. Refractory sprue. Curr Gastroenterol Rep. 2003;5:373-8.
62. Fine KD, Meyer RL, Lee EL. The prevalence and causes of chronic diarrhea in patients with celiac sprue treated with a gluten-free diet. Gastroenterology. 1997;112:1830-8.
63. Cellier C, Delabesse E, Helmer C, Patey N, Matuchansky C, Jabri B, et al. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet. 2000;356:203-8.
64. Gomez JC, Moran CE, Maurino EC, Bai JC. Exocrine pancreatic insufficiency in celiac disease [Letter]. Gastroenterology. 1998;114:621-3.
65. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997;3:797-801.
66. Korponay-Szabo, Laurila K, Szondy Z, Halttunen T, Szalai Z, Dahlbom I, et al. Missing endomysial and reticulin binding of coeliac antibodies in transglutaminase 2 knockout tissues. Gut. 2003;52:199-204.
67. Korponay-Szabo, Sulkanen S, Halttunen T, Maurano F, Rossi M, Mazzarella G, et al. Tissue transglutaminase is the target in both rodent and primate tissues for celiac disease-specific autoantibodies. J Pediatr Gastroenterol Nutr. 2000;31:520-7.
68. Wong RC, Wilson RJ, Steele RH, Radford-Smith G, Adelstein S. A comparison of 13 guinea pig and human anti-tissue transglutaminase antibody ELISA kits. J Clin Pathol. 2002;55:488-94.
69. Sardy M, Odenthal U, Karpati S, Paulsson M, Smyth N. Recombinant human tissue transglutaminase ELISA for the diagnosis of gluten-sensitive enteropathy. Clin Chem. 1999;45:2142-9.
70. Clemente MG, Musu MP, Frau F, Lucia C, De Virgiliis S. Antitissue transglutaminase antibodies outside celiac disease. J Pediatr Gastroenterol Nutr. 2002;34:31-4.
71. Carroccio A, Giannitrapani L, Soresi M, Not T, Iacono G, Di Rosa C, et al. Guinea pig transglutaminase immunolinked assay does not predict coeliac disease in patients with chronic liver disease. Gut. 2001;49:506-11.
72. Bonamico M, Tiberti C, Picarelli A, Mariani P, Rossi D, Cipolletta E, et al. Radioimmunoassay to detect antitransglutaminase autoantibodies is the most sensitive and specific screening method for celiac disease. Am J Gastroenterol. 2001;96:1536-40.
73. Tursi A, Brandimarte G, Giorgetti GM. Prevalence of antitissue transglutaminase antibodies in different degrees of intestinal damage in celiac disease. J Clin Gastroenterol. 2003;36:219-21.
74. Rostami K, Kerckhaert J, Tiemessen R, von Blomberg BM, Meijer JW, Mulder CJ. Sensitivity of antiendomysium and antigliadin antibodies in untreated celiac disease: disappointing in clinical practice. Am J Gastroenterol. 1999;94:888-94.
75. Fasano A, Not T, Wang W, Uzzau S, Berti I, Tommasini A, et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease [Letter]. Lancet. 2000;355:1518-9.
76. Shan L, Molberg O, Parrot I, Hausch F, Filiz F, Gray GM, et al. Structural basis for gluten intolerance in celiac sprue. Science. 2002;297:2275-9.
77. Pender SL, Tickle SP, Docherty AJ, Howie D, Wathen NC, MacDonald TT. A major role for matrix metalloproteinases in T cell injury in the gut. J Immunol. 1997;158:1582-90.
78. Daum S, Bauer U, Foss HD, Schuppan D, Stein H, Riecken EO, et al. Increased expression of mRNA for matrix metalloproteinases-1 and -3 and tissue inhibitor of metalloproteinases-1 in intestinal biopsy specimens from patients with coeliac disease. Gut. 1999;44:17-25.
79. Lundqvist C, Melgar S, Yeung MM, Hammarstrom S, Hammarstrom ML. Intraepithelial lymphocytes in human gut have lyric potential and a cytokine profile that suggest T helper 1 and cytotoxic functions. J Immunol. 1996;157:1926-34.
80. Oberhuber G, Vogelsang H, Stolte M, Muthenthaler S, Kummer AJ, Radaszkiewicz T. Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis. Am J Pathol. 1996;148:1351-7.
81. Hue S, Mention JJ, Monteiro RC, Zhang S, Cellier C, Schmitz J, et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity. 2004;21:367-77.
82. Maiuri L, Ciacci C, Ricciardelli I, Vacca L, Raia V, Auricchio S, et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet. 2003;362:30-7.
83. Meresse B, Chen Z, Ciszewski C, Tretiakova M, Bhagat G, Krausz TN, et al. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity. 2004;21:357-66.
84. Gianfrani C, Troncone R, Mugione P, Cosentini E, De Pascale M, Faruolo C, et al. Celiac disease association widi CD8 + T cell responses: identification of a novel gliadin-derived HLA-A2-restricted epitope. J Immunol. 2003;170:2719-26.
85. Lorand L, Conrad SM. Transglutaminases. Mol Cell Biochem. 1984;58:9-35.
86. Folk JE, Chung SI. Transglutaminases. Methods Enzymol. 1985;113:358-75.
87. Nemes Z, Steinert PM. Bricks and mortar of the epidermal barrier. Exp Mol Med. 1999;31:5-19.
88. Griffin M, Casadio R, Bergamini CM. Transglutaminases: nature's biological glues. Biochem J. 2002;368:377-96.
89. Bruce SE, Bjarnason I, Peters TJ. Human jejunal transglutaminase: demonstration of activity, enzyme kinetics and substrate specificity with special relation to gliadin and coeliac disease. Clin Sci (Lond). 1985;68:573-9.
90. Esposito C, Paparo F, Caputo I, Porta R, Salvati VM, Mazzarella G, et al. Expression and enzymatic activity of small intestinal tissue transglutaminase in celiac disease. Am J Gastroenterol. 2003;98:1813-20.
91. Fesus L, Piacentini M. Transglutaminase 2: an enigmatic enzyme with diverse functions. Trends Biochem Sci. 2002;27:534-9.
92. Lai TS, Slaughter TF, Peoples KA, Hettasch JM, Greenberg CS. Regulation of human tissue transglutaminase function by magnesium-nucleotide complexes. Identification of distinct binding sites for Mg-GTP and Mg-ATP. J Biol Chem. 1998;273:1776-81.
93. Sollid LM. Molecular basis of celiac disease. Annu Rev Immunol. 2000;18:53-81.
94. Molberg O, McAdam SN, Sollid LM. Role of tissue transglutaminase in celiac disease. J Pediatr Gastroenterol Nutr. 2000;30:232-40.
95. Sulkanen S, Halttunen T, Laurila K, Kolho KL, et al. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology. 1998;115:1322-8.
96. Nunes I, Gleizes PE, Metz CN, Rifkin DB. Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta. J Cell Biol. 1997;136:1151-63.
97. Halttunen T, Marttinen A, Rantala I, Kainulainen H, Maki M. Fibroblasts and transforming growth factor beta induce organization and differentiation of T84 human epithelial cells. Gastroenterology. 1996;111:1252-62.
98. Dignass AU, Podolsky DK. Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta. Gastroenterology. 1993;105:1323-32.
99. Esposito C, Paparo F, Caputo I, Rossi M, Maglio M, Sblattero D, et al. Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ. Gut. 2002;51:177-81.
100. Reunala TL. Dermatitis herpetiformis. Clin Dermatol. 2001;19:728-36.
101. Fry L. Dermatitis herpetiformis: problems, progress and prospects. Eur J Dermatol. 2002;12:523-31.
102. Porter WM, Unsworth DJ, Lock RJ, Hardman CM, Baker BS, Fry L. Tissue transglutaminase antibodies in dermatitis herpetiformis [Letter]. Gastroenterology. 1999;117:749-50.
103. Sardy M, Karpati S, Merkl B, Paulsson M, Smyth N. Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis. J Exp Med. 2002;195:747-57.
104. Kaukinen K, Salmi J, Lahtela J, Siljamaki-Ojansuu U, Koivisto AM, Oksa H, et al. No effect of gluten-free diet on the metabolic control of type 1 diabetes in patients with diabetes and celiac disease. Retrospective and controlled prospective survey [Letter]. Diabetes Care. 1999;22:1747-8.
105. Askling J, Linet M, Gridley G, Halstensen TS, Ekstrom K, Ekbom A. Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. Gastroenterology. 2002;123:1428-35.
106. Green PH, Fleischauer AT, Bhagat G, Goyal R, Jabri B, Neugut AI. Risk of malignancy in patients with celiac disease. Am J Med. 2003;115:191-5.
107. Muller AF, Donnelly MT, Smith CM, Grundman MJ, Holmes GK, Toghill PJ. Neurological complications of celiac disease: a rare but continuing problem. Am J Gastroenterol. 1996;91:1430-5.
108. Chin RL, Latov N, Green PH, Brannagan TH, Alaedini A, Sander HW. Neurological complications of celiac disease. J Clin Neuromusc Dis. 2004;5:129-37.
109. Cicarelli G, Della Rocca G, Amboni M, Ciacci C, Mazzacca G, Filla A, et al. Clinical and neurological abnormalities in adult celiac disease. Neurol Sci. 2003;24:311-7.
110. Polizzi A, Finocchiaro M, Parano E, Pavone P, Musumeci S, Polizzi A. Recurrent peripheral neuropathy in a girl with celiac disease [Letter]. J Neurol Neurosurg Psychiatry. 2000;68:104-5.
111. Kaplan JG, Pack D, Horoupian D, DeSouza T, Brin M, Schaumburg H. Distal axonopathy associated with chronic gluten enteropathy: a treatable disorder. Neurology. 1988;38:642-5.
112. Hadjivassiliou M, Davies-Jones GA, Sanders DS, Grunewald RA. Dietary treatment of gluten ataxia. J Neurol Neurosurg Psychiatry. 2003;74:1221-4.
113. Dalton TA, Bennett JC. Autoimmune disease and the major histocompatibility complex: therapeutic implications. Am J Med. 1992;92:183-8.
114. Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet. 2001;358:221-9.
115. Buzzetti R, Quattrocchi CC, Nistico. Dissecting the genetics of type 1 diabetes: relevance for familial clustering and differences in incidence. Diabetes Metab Rev. 1998;14:111-28.
116. Mori M, Kuwabara S, Miyake M, Dezawa M, Adachi-Usami E, Kuroki H, et al. Haemophilus influenzae has a GM1 ganglioside-like structure and elicits Guillain-Barré syndrome. Neurology. 1999;52:1282-4.
117. Yuki N, Taki T, Inagaki F, Kasama T, Takahashi M, Saito K, et al. A bacterium lipopolysaccharide that elicits Guillain-Barre syndrome has a GM1 ganglioside-like structure. J Exp Med. 1993;178:1771-5.
118. Basu D, Horvath S, Matsumoto I, Fremont DH, Allen PM. Molecular basis for recognition of an arthritic peptide and a foreign epitope on distinct MHC molecules by a single TCR. J Immunol. 2000;164:5788-96.
119. Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, et al. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol. 2002;3:940-3.
120. Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 1995;80:695-705.
121. Gomis R, Sener A, Malaisse-Lagae F, Malaisse WJ. Transglutaminase activity in pancreatic islets. Biochim Biophys Acta. 1983;760:384-8.
122. Driscoll HK, Adkins CD, Chertow TE, Cordle MB, Matthews KA, Chertow BS. Vitamin A stimulation of insulin secretion: effects on transglutaminase mRNA and activity using rat islets and insulin-secreting cells. Pancreas. 1997;15:69-77.