Corticosteroid Receptor Transgenic Mice: Models for Depression?

Annals of the New York Academy of Sciences

Volumn 1007, Issue , 2003, Pages 379-393

  Urani, Alexandre ^a   Gass, Peter ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

Animal model; Depression; Glucocorticoid receptor; Mineralocorticoid receptor; Transgenic mice

Indexed keywords

ANTIDEPRESSANT AGENT; CORTICOSTEROID; CORTICOSTEROID RECEPTOR; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; DNA; GLUCOCORTICOID RECEPTOR; LITHIUM; MINERALOCORTICOID RECEPTOR; RESERPINE;

ANIMAL BEHAVIOR; ANXIETY; BEHAVIOR; CONFERENCE PAPER; DEPRESSION; DISEASE PREDISPOSITION; DNA BINDING; ELECTROCONVULSIVE THERAPY; EMOTIONAL DISORDER; EXPOSURE; GENE IDENTIFICATION; GENE MUTATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC MODEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; KNOCKOUT MOUSE; LOCOMOTION; MOUSE MUTANT; MOUSE STRAIN; NERVOUS SYSTEM; NONHUMAN; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; STRESS; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 1342330471     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1286.037     Document Type: Conference Paper

References (74)

1. HOLSBOER, F. 2000. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23: 477-501.
2. GIBBONS, J.L. 1964. Cortisol secretion rate in depressive illness. Arch. Gen. Psychiatry 10: 572-575.
3. DOLAN, R.J., S.P. CALLOWAY, et al. 1985. Life events, depression and hypothalamic-pituitary-adrenal axis function. Br. J. Psychiatry 147: 429-433.
4. RUBIN, R.T., R.E. POLAND, et al. 1987. Neuroendocrine aspects of primary endogenous depression. I. Cortisol secretory dynamics in patients and matched controls. Arch. Gen. Psychiatry 44: 328-336.
5. DEAKIN, J.F., I. PENNELL, et al. 1990. A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. Psychopharmacology 101: 85-92.
6. WONG, M.L., M.A. KLING, et al. 2000. Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone. Proc. Natl. Acad. Sci. USA 97: 325-330.
7. STRICKLAND, P.L., J.F. DEAKIN, et al. 2002. Bio-social origins of depression in the community. Interactions between social adversity, cortisol and serotonin neurotransmission. Br. J. Psychiatry 180: 168-173.
8. GOLD, P.W., W.C. DREVETS, et al. 2002. New insights into the role of cortisol and the glucocorticoid receptor in severe depression. Biol. Psychiatry 52: 381-385.
9. HOLSBOER, F. & N. BARDEN. 1996. Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr. Rev. 17: 187-205.
10. BHAGWAGAR, Z., S. HAFIZI, et al. 2002. Acute citalopram administration produces correlated increases in plasma and salivary cortisol. Psychopharmacology 163: 118-120.
11. STECKLER, T., F. HOLSBOER, et al. 1999. Glucocorticoids and depression. Baillieres Best Pract. Res. Clin. Endocrinol. Metab. 13: 597-614.
12. BELANOFF, J.K., A.J. ROTHSCHILD, et al. 2002. An open label trial of C-1073 (mifepristone) for psychotic major depression. Biol. Psychiatry 52: 386-392.
13. WOLKOWITZ, O.M., V.I. REUS, et al. 1993. Ketoconazole administration in hypercortisolemic depression. Am. J. Psychiatry 150: 810-812.
14. WOLKOWITZ, O.M., V.I. REUS, et al. 1999. Antiglucocorticoid treatment of depression: double-blind ketoconazole. Biol. Psychiatry 45: 1070-1074.
15. REUL, J.M. & E.R. DE KLOET. 1985. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 117: 2505-2511.
16. DE KLOET, E.R. & J.M. REUL. 1987. Feedback action and tonic influence of corticosteroids on brain function: a concept arising from the heterogeneity of brain receptor systems. Psychoneuroendocrinology 12: 83-105.
17. DE KLOET, E.R., E. VREUGDENHIL, et al. 1998. Brain corticosteroid receptor balance in health and disease. Endocr. Rev. 19: 269-301.
18. JOELS, M. & E. VREUGDENHIL. 1998. Corticosteroids in the brain. Cellular and molecular actions. Mol. Neurobiol. 17: 87-108.
19. TRONCHE, F., C. KELLENDONK, et al. 1998. Genetic dissection of glucocorticoid receptor function in mice. Curr. Opin. Genet. Dev. 8: 532-538.
20. YANG-YEN, H.F., J.C. CHAMBARD, et al. 1990. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62: 1205-1215.
21. IMAI, E., J.N. MINER, et al. 1993. Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J. Biol. Chem. 268: 5353-5356.
22. STOCKLIN, E., M. WISSLER, et al. 1996. Functional interactions between Stat5 and the glucocorticoid receptor. Nature 383: 726-728.
23. JOELS, M. & E.R. DE KLOET. 1994. Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems. Prog. Neurobiol. 43: 1-36.
24. DE KLOET, E.R., M.S. OITZL, et al. 1999. Stress and cognition: are corticosteroids good or bad guys? Trends Neurosci. 22: 422-426.
25. JOELS, M. 2000. Modulatory actions of steroid hormones and neuropeptides on electrical activity in brain. Eur. J. Pharmacol. 405: 207-216.
26. PORSOLT, R.D., M. LE PICHON, et al. 1977. Depression: a new animal model sensitive to antidepressant treatments. Nature 266: 730-732.
27. STERU, L., R. CHERMAT, et al. 1985. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85: 367-370.
28. WILLNER, P. 1997. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology 134: 319-329.
29. WILLNER, P., R. MUSCAT, et al. 1992. Chronic mild stress-induced anhedonia: a realistic animal model of depression. Neurosci. Biobehav. Rev. 16: 525-534.
30. BOURIN, M. 1990. Is it possible to predict the activity of a new antidepressant in animals with simple psychopharmacological tests? Fundam. Clin. Pharmacol. 4: 49-64.
31. ALMEIDA, R.N., D.S. NAVARRO, et al. 1998. Antidepressant effect of an ethanolic extract of the leaves of Cissampelos sympodialis in rats and mice. J. Ethnopharmacol. 63: 247-252.
32. SKALISZ, L.L., V. BEIJAMINI, et al. 2002. Evaluation of the face validity of reserpine administration as an animal model of depression- Parkinson's disease association. Prog. Neuropsychopharmacol. Biol. Psychiatry 26: 879-883.
33. REDROBE, J.P. & M. BOURIN. 1999. The effect of lithium administration in animal models of depression: a short review. Fundam. Clin. Pharmacol. 13: 293-299.
34. VETULANI, J., L. ANTKIEWICZ-MICHALUK, et al. 1986. Effects of chronically administered antidepressants and electroconvulsive treatment on cerebral neurotransmitter receptors in rodents with 'model depression'. Ciba Found. Symp. 123: 234-245.
35. NAGAYAMA, H., J.N. HINGTGEN, et al. 1980. Pre-and postsynaptic serotonergic manipulations in an animal model of depression. Pharmacol. Biochem. Behav. 13: 575-579.
36. KELLENDONK, C., F. TRONCHE, et al. 1999. Mutagenesis of the glucocorticoid receptor in mice. J. Steroid Biochem. Mol. Biol. 69: 253-259.
37. ROSSANT, J. & A. MCMAHON. 1999. "Cre"-ating mouse mutants-a meeting review on conditional mouse genetics. Genes Dev. 13: 142-145.
38. PEPIN, M.C., F. POTHIER, et al. 1992. Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene. Nature 355: 725-728.
39. KARANTH, S., A.C. LINTHORST, et al. 1997. Hypothalamic-pituitary- adrenocortical axis changes in a transgenic mouse with impaired glucocorticoid receptor function. Endocrinology 138: 3476-3485.
40. BARDEN, N., I.S. STEC, et al. 1997. Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor. Neuroendocrinology 66: 212-220.
41. DIJKSTRA, I., F.J. TILDERS, et al. 1998. Reduced activity of hypothalamic corticotropin-releasing hormone neurons in transgenic mice with impaired glucocorticoid receptor function. J. Neurosci. 18: 3909-3918.
42. PEPIN, M.C., F. POTHIER, et al. 1992. Antidepressant drug action in a transgenic mouse model of the endocrine changes seen in depression. Mol. Pharmacol. 42: 991-995.
43. MONTKOWSKI, A., N. BARDEN, et al. 1995. Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function. J. Neuroendocrinol. 7: 841-845.
44. BARDEN, N. 1996. Modulation of glucocorticoid receptor gene expression by antidepressant drugs. Pharmacopsychiatry 29: 12-22.
45. LINTHORST, A.C., C. FLACHSKAMM, et al. 2000. Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice. Eur. J. Neurosci. 12: 283-291.
46. HEINRICHS, S.C., J. LAPSANSKY, et al. 1997. Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior. Regul. Pept. 71: 15-21.
47. TIMPL, P., R. SPANAGEL, et al. 1998. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat. Genet. 19: 162-166.
48. SMITH, G.W., J.M. AUBRY, et al. 1998. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 20: 1093-1102.
49. LIEBSCH, G., R. LANDGRAF, et al. 1999. Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain. J. Psychiatry Res. 33: 153-163.
50. STECKLER, T. & F. HOLSBOER. 1999. Enhanced conditioned approach responses in transgenic mice with impaired glucocorticoid receptor function. Behav. Brain Res. 102: 151-163.
51. COLE, T.J., J.A. BLENDY, et al. 1995. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 9: 1608-1621.
52. COLE, T.J., K. MYLES, et al. 2001. GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant. Mol. Cell. Endocrinol. 173: 193-202.
53. CHRISTOFFELS, V.M., T. GRANGE, et al. 1998. Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene. Mol. Cell. Biol. 18: 6305-6315.
54. REICHARDT, H.M. & G. SCHUTZ. 1996. Feedback control of glucocorticoid production is established during fetal development. Mol. Med. 2: 735-744.
55. TRONCHE, F., C. KELLENDONK, et al. 1999. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat. Genet. 23: 99-103.
56. GOLD, P.W., F.K. GOODWIN, et al. 1988. Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress (1). N. Engl. J. Med. 319: 348-353.
57. REICHARDT, H.M. & G. SCHUTZ. 1998. Glucocorticoid signalling: multiple variations of a common theme. Mol. Cell. Endocrinol. 146: 1-6.
58. HECK, S., M. KULLMANN, et al. 1994. A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J. 13: 4087-4095.
59. REICHARDT, H.M., K.H. KAESTNER, et al. 1998. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93: 531-541.
60. TUCKERMANN, J.P., H.M. REICHARDT, et al. 1999. The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin. J. Cell. Biol. 147: 1365-1370.
61. MALKOSKI, S.P. & R.I. DORIN. 1999. Composite glucocorticoid regulation at a functionally defined negative glucocorticoid response element of the human corticotropin-releasing hormone gene. Mol. Endocrinol. 13: 1629-1644.
62. DROUIN, J., Y.L. SUN, et al. 1993. Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J. 12: 145-156.
63. SAKAI, D.D., S. HELMS, et al. 1988. Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene. Genes Dev. 2: 1144-1154.
64. OITZL, M.S., H.M. REICHARDT, et al. 2001. Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory. Proc. Natl. Acad. Sci. USA 98: 12790-12795.
65. KARST, H., Y.J. KARTEN, et al. 2000. Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers. Nat. Neurosci. 3: 977-978.
66. REICHARDT, H.M., T. UMLAND, et al. 2000. Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock. Mol. Cell. Biol. 20: 9009-9017.
67. WEI, Q., G.L. SCHAFER, et al. 2001. Tissue-specific overexpression of the glucocorticoid receptor in the brain. Soc. Neurosci. Abstr. 27.
68. BERGER, S., M. BLEICH, et al. 1998. Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism. Proc. Natl. Acad. Sci. USA 95: 9424-9429.
69. BLEICH, M., R. WARTH, et al. 1999. Rescue of the mineralocorticoid receptor knockout mouse. Pflugers Arch. 438: 245-254.
70. GASS, P., O. KRETZ, et al. 2000. Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice. EMBO Rep. 1: 447-451.
71. ANISMAN, H., M.D. ZAHARIA, et al. 1998. Do early-life events permanently alter behavioral and hormonal responses to stressors? Int. J. Dev. Neurosci. 16: 149-164.
72. BARDEN, N., J.M. REUL, et al. 1995. Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system? Trends Neurosci. 18: 6-11.
73. GERLAI, R. 1996. Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci. 19: 177-181.
74. GERLAI, R. 2000. Targeting genes and proteins in the analysis of learning and memory: caveats and future directions. Rev. Neurosci. 11: 15-26.