Nonlysine-analog plasmmogen modulators promote autoproteolytic generation of plasmin(ogen) fragments with angiostatin-like activity

European Journal of Biochemistry

Volumn 271, Issue 4, 2004, Pages 809-820

  Ohyama, Shigeki ^a   Harada, Tomotaka ^a   Chikanishi, Toshihiro ^a   Miura, Yutaka ^a   Hasumi, Keiji ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Angiogenesis; Angiostatin; Autoproteolysis; Plasmin; Plasminogen

Indexed keywords

AMINOCAPROIC ACID; ANGIOSTATIN; APROTININ; COMPLESTATIN; PEPTIDE FRAGMENT; PLASMIN; PLASMIN INHIBITOR; PLASMINOGEN; PLASMINOGEN ACTIVATOR; SMTP 6; THIOPLABIN B; UNCLASSIFIED DRUG; UROKINASE; 2 PYRROLIDONE DERIVATIVE; AMINO ACID; BENZOPYRAN DERIVATIVE; CHLOROPHENOL; CYCLOPEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; ANIMAL; BINDING SITE; CATTLE; CELL DIVISION; CHEMISTRY; CHO CELL; CYTOLOGY; GENETICS; HAMSTER; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MOUSE; SEQUENCE ANALYSIS; TUMOR CELL LINE; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

6-AMINOCAPROIC ACID; AMINO ACIDS; ANGIOSTATINS; ANIMALS; BENZOPYRANS; BINDING SITES; CATTLE; CELL DIVISION; CELL LINE, TUMOR; CHLOROPHENOLS; CHO CELLS; CRICETINAE; ENDOTHELIUM, VASCULAR; HUMANS; MASS SPECTROMETRY; MICE; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATORS; PYRROLIDINONES; SEQUENCE ANALYSIS, PROTEIN; UMBILICAL VEINS;

EID: 1342322690     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.03985.x     Document Type: Article

References (41)

1. Carmeliet, P. & Collen, D. (1995) Gene targeting and gene transfer studies of the plasminogen/plasmin system: implications in thrombosis, hemostasis, neointima formation, and atherosclerosis. FASEB J. 9, 934-938.
2. Tryggvason, K., Höyhtyä, M. & Salo, T. (1987) Proteolytic degradation of extracellular matrix in tumor invasion. Biochim. Biophys. Acta 907, 191-217.
3. Pepper, M.S. (2001) Extracellular proteolysis and angiogenesis. Thromb. Haemost. 86, 346-355.
4. Forsgren, M., Raden, B., Israelsson, M., Larsson, K. & Heden, L.O. (1987) Molecular cloning and characterization of a full-length cDNA clone for human plasminogen. FEBS Lett. 213, 254-260.
5. Mangel, W.F., Lin, B.H. & Ramakrishnan, V. (1990) Characterization of an extremely large, ligand-induced conformational change in plasminogen. Science 248, 69-73.
6. An, S.S., Carreno, C., Marti, D.N., Schaller, J., Albericio, F. & Llinas, M. (1998) Lysine-50 is a likely site for anchoring the plasminogen N-terminal peptide to lysine-binding kringles. Protein Sci. 7, 1960-1969.
7. Cockell, C.S., Marshall, J.M., Dawson, K.M., Cederholm-Williams, S.A. & Ponting, C.P. (1998) Evidence that the conformation of unliganded human plasminogen is maintained via an intramolecular interaction between the lysine-binding site of kringle 5 and the N-terminal peptide. Biochem. J. 333, 99-105.
8. Hajjar, K.A. (1995) Cellular receptors in the regulation of plasmin generation. Thromb. Haemost. 74, 294-301.
9. Lucas, M.A., Fretto, L.J. & McKee, P.A. (1983) The binding of human plasminogen to fibrin and fibrinogen. J. Biol. Chem. 258, 4249-4256.
10. Gong, Y., Kim, S.O., Felez, J., Grella, D.K., Castellino, F.J. & Miles, L.A. (2001) Conversion of Glu-plasminogen to Lys-plasminogen is necessary for optimal stimulation of plasminogen activation on the endothelial cell surface. J. Biol. Chem. 276, 19078-19083.
11. Molgaard, L., Ponting, C.P. & Christensen, U. (1997) Glycosylation at Asn-289 facilitates the ligand-induced conformational changes of human Glu-plasminogen. FEBS Lett. 405, 363-368.
12. O'Reilly, M.S., Holmgren, L., Shing, Y., Chen, C., Rosenthal, R.A., Moses, M., Lane, W.S., Cao, Y., Sage, E.H. & Folkman, J. (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79, 315-328.
13. Cao, Y., Ji, R.W., Davidson, D., Schaller, J., Marti, D., Sohndel, S., McCance, S.G., O'Reilly, M.S., Llinas, M. & Folkman, J. (1996) Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells. J. Biol. Chem. 271, 29461-29467.
14. Cao, Y., Chen, A., An, S.S., Ji, R.W., Davidson, D. & Llinas, M. (1997) Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth. J. Biol. Chem. 272, 22924-22928.
15. Cao, R., Wu, H.L., Veitonmäki, N., Linden, P., Farnebo, J., Shi, G.Y. & Cao, Y. (1999) Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis. Proc. Natl Acad. Sci. USA 96, 5728-5733.
16. Kassam, G., Kwon, M., Yoon, C.S., Graham, K.S., Young, M.K., Gluck, S. & Waisman, D.M. (2001) Purification and characterization of A61. An angiostatin-like plasminogen fragment produced by plasmin autodigestion in the absence of sulfhydryl donors. J. Biol Chem. 276, 8924-8933.
17. Kwon, M., Yoon, C.S., Fitzpatrick, S., Kassam, G., Graham, K.S., Young, M.K. & Waisman, D.M. (2001) p22 is a novel plasminogen fragment with antiangiogenic activity. Biochemistry 40, 13246-13253.
18. Lijnen, H.R., Ugwu, F., Bini, A. & Collen, D. (1998) Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3). Biochemistry 37, 4699-4702.
19. Cornelius, L.A., Nehring, L.C., Harding, E., Bolanowski, M., Welgus, H.G., Kobayashi, D.K., Pierce, R.A. & Shapiro, S.D. (1998) Matrix metalloproteinases generate angiostatin: effects on neovascularization. J. Immunol. 161, 6845-6852.
20. Morikawa, W., Yamamoto, K., Ishikawa, S., Takemoto, S., Ono, M., Fukushi, J., Naito, S., Nozaki, C., Iwanaga, S. & Kuwano, M. (2000) Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells. J. Biol. Chem. 275, 38912-38920.
21. Lay, A.J., Jiang, X.M., Kisker, O., Flynn, E., Underwood, A., Condron, R. & Hogg, P.J. (2000) Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide reductase. Nature 408, 869-873.
22. O'Reilly, M.S., Holmgren, L., Chen, C. & Folkman, J. (1996) Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat. Med. 2, 689-692.
23. Sim, B.K., O'Reilly, M.S., Liang, H., Fortier, A.H., He, W., Madsen, J.W., Lapcevich, R. & Nacy, C.A. (1997) A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer. Cancer Res. 57, 1329-1334.
24. Takayasu, R., Hasumi, K., Shinohara, C. & Endo, A. (1997) Enhancement of fibrin binding and activation of plasminogen by staplabin through induction of a conformational change in plasminogen. FEBS Lett. 418, 58-62.
25. Hasumi, K., Ohyama, S., Kohyama, T., Ohsaki, Y., Takayasu, R. & Endo, A. (1998) Isolation of SMTP-3-4-5 and -6, novel analogs of staplabin, and their effects on plasminogen activation and fibrinolysis. J. Antibiot. (Tokyo) 51, 1059-1068.
26. Ohyama, S., Wada, Y. & Hasumi, K. (2002) Antibiotic A10255 (thioplabin) enhances fibrin binding and activation of plasminogen. J. Antibiot. (Tokyo) 55, 83-91.
27. Tachikawa, K., Hasumi, K. & Endo, A. (1997) Enhancement of plasminogen binding to U937 cells and fibrin by complestatin. Thromb. Haemost. 77, 137-142.
28. Kjkuchi, T. & Hasumi, K. (2002) Enhancement of plasminogen activation by surfactin C: augmentation of fibrinolysis in vitro and in vivo. Biochim. Biophys. Acta 1596, 234-245.
29. Hu, W., Ohyama, S. & Hasumi, K. (2000) Activation of fibrinolysis by SMTP-7 and - 8, novel staplabin analogs with a pseudosymmetric structure. J. Antibiot. (Tokyo) 53, 241-247.
30. Deutsch, D.G. & Mertz, E.T. (1970) Plasminogen: purification from human plasma by affinity chromatography. Science 170, 1095-1096.
31. Lay, A.J., Jiang, X.M., Daly, E., Sun, L. & Hogg, P.J. (2002) Plasmin reduction by phosphoglycerate: kinase is a thiol-independent process. J. Biol. Chem. 277, 9062-9068.
32. Stathakis, P., Lay, A.J., Fitzgerald, M., Schlieker, C., Matthias, L.J. & Hogg, P.J. (1999) Angiostatin formation involves disulfide bond reduction and proteolysis in kringle 5 of plasmin. J. Biol. Chem. 274, 8910-8916.
33. Claesson-Welsh, L., Welsh, M., Ito, N., Anand-Apte, B., Soker, S., Zetter, B., O'Reilly, M. & Folkman, J. (1998) Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD. Proc. Natl Acad. Sci. USA 95, 5579-5583.
34. Lucas, R., Holmgren, L., Garcia, I., Jimenez, B., Mandriota, S.J., Borlat, F., Sim, B.K., Wu, Z., Grau, G.E., Shing, Y., Soff, G.A., Bouck, N. & Pepper, M.S. (1998) Multiple forms of angiostatin induce apoptosis in endothelial cells. Blood 92, 4730-4741.
35. Ueshima, S., Okada, K. & Matsuo, O. (1996) Stabilization of plasmin by lysine derivatives. Clin. Chim. Acta 245, 7-18.
36. Wu, H.L., Shi, G.Y., Wohl, R.C. & Bender, M.L. (1987) Structure and formation of microplasmin. Proc. Natl Acad. Sci. USA 84, 8793-S795.
37. Shi, G.Y. & Wu, H.L. (1988) Differential autolysis of human plasmin at various pH levels. Thromb. Res. 51, 355-364.
38. Fitzpatrick, S.L., Kassam, G., Choi, K.S., Kang, H.M., Fogg, D.K. & Waisman, D.M. (2000) Regulation of plasmin activity by annexin II tetramer. Biochemistry 39, 1021-1028.
39. Choi, K.S., Fitzpatrick, S.L., Filipenko, N.R., Fogg, D.K., Kassam, G., Magliocco, A.M. & Waisman, D.M. (2001) Regulation of plasmin-dependent fibrin clot lysis by annexin II heterotetramer. J. Biol. Chem. 276, 25212-25221.
40. Kang, H.M., Choi, K.S., Kassam, G., Fitzpatrick, S.L., Kwon, M. & Waisman, D.M. (1999) Role of annexin II tetramer in plasminogen activation. Trends Cardiovasc. Med. 9, 92-102.
41. Cao, Y. (2001) Endogenous angiogenesis inhibitors and their therapeutic implications. Int. J. Biochem. Cell Biol. 33, 357-369.