Activation of fibrinolysis by SMTP-7 and -8, novel staplabin analogs with a pseudosymmetric structure

Journal of Antibiotics

Volumn 53, Issue 3, 2000, Pages 241-247

  Hu, Weimin ^a   Ohyama, Shigeki ^a   Hasumi, Keiji ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE; ORNITHINE; PLASMINOGEN; PLASMINOGEN ACTIVATOR; SMTP 7; SMTP 8; STAPLABIN ANALOG; UNCLASSIFIED DRUG; UROKINASE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; FIBRINOLYSIS; HYPHOMYCETES; NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL;

EID: 0034072918     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.53.241     Document Type: Article

References (21)

1. OPDENAKKER, G. & J. VAN DAMME: Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer. Cytokine 4: 251-258, 1992
2. CARMELIET, P. & D. COLLEN: Role of the plasminogen/ plasmin system in thrombosis, hemostasis, restenosis, and atherosclerosis. Evaluation in transgenic animals. Trends Cardiovasc. Med. 5: 117-122, 1995
3. SCHMITT, M.; N. HARBECK, C. THOMSSEN, O. WILHELM, V. MAGDOLEN, U. REUNING, K. ULM, H. HÖFLER, F. JÄNICKE & H. GRAEFF: Clinical impact of the plasminogen activation system in tumor invasion and metastasis: prognostic relevance and target for therapy. Thromb. Haemost. 78: 285-296, 1997
4. BOYLE, M. D. & R. LOTTENBERG: Plasminogen activation by invasive human pathogens. Thromb. Haemost. 77: 1-10, 1997
5. FORSGREN, M.; B. RADEN, M ISRAELSSON, K. LARSSON & L.-O. HEDEN: Molecular cloning and characterization of a full-length cDNA clone for human plasminogen. FEBS Lett. 213: 254-260, 1987
6. PLOW, E. F.; T. HERREN, A. REDLITZ, L. A. MILES & J. L. HOOVER-PLOW: The cell biology of the plasminogen system. FASEB J. 9: 939-945, 1995
7. CHRISTENSEN, U.: The AH-site of plasminogen and two C-terminal fragments. A weak lysine-binding site preferring ligands not carrying a free carboxylate function. Biochem. J. 223: 413-421, 1984
8. MARSHALL, J. M.; A. J. BROWN & C. P. PONTING: Conformational studies of human plasminogen and plasminogen fragments: evidence for a novel third conformation of plasminogen. Biochemistry 33: 3599-3606, 1994
9. AN, S. S.; C. CARRENO, D. N. MARTI, J. SCHALLER, F. ALBERICO & M. LLINAS: Lysine-50 is a likely site for anchoring the plasminogen N-terminal peptide to lysine-binding kringles. Protein Sci. 7: 1960-1969, 1998
10. COCKELL, C. S.; J. M. MARSHALL, K. M. DAWSON, S. A. CEDERHOLM-WILLIAMS & C. P. PONTING: Evidence that the conformation of unliganded human plasminogen is maintained via an intramolecular interaction between the lysine-binding site of kringle 5 and the N-terminal peptide. Biochem. J. 333: 99-105, 1998
11. NESHEIM, M. E.; J. C. FREDENBURGH & G. R. LARSEN: The dissociation constants and stoichiometries of the interactions of Lys-plasminogen and chloromethyl ketone derivatives of tissue plasminogen activator and the variant ΔFEIX with intact fibrin. J. Biol. Chem. 265: 21541-21548, 1990
12. HAJJAR, K. A. &R. L. NACMAN: Endothelial cell-mediated conversion of Glu-plasminogen to Lys-plasminogen. Further evidence for assembly of the fibrinolytic system on the endothelial cell surface. J. Clin. Invest. 82: 1769-1778, 1988
13. SHINOHARA, C.; K. HASUMI, W. HATSUMI & A. ENDO: Staplabin, a novel fungal triprenyl phenol which stimulates the binding of plasminogen to fibrin and U937 cells. J. Antibiotics 49: 961-966, 1996
14. TAKAYASU, R.; K. HASUMI, C. SHINOHARA & A. ENDO: Enhancement of fibrin binding and activation of plasminogen by staplabin through induction of a conformational change in plasminogen. FEBS Lett. 418: 58-62, 1997
15. KOHYAMA, T.; K. HASUMI, A. HAMANAKA & A. ENDO: SMTP-1 and -2, novel analogs of staplabin produced by Stachybotrys microspora IFO30018. J. Antibiotics 50: 172-174, 1997
16. HASUMI, K.; S. OHYAMA, T. KOHYAMA, Y. OHSAKI, R. TAKAYASU & A. ENDO: Isolation of SMTP-3, -4, -5 and -6, novel analogs of staplabin, and their effects on plasminogen activation and fibrinolysis. J. Antibiotics 51: 1059-1068, 1998
17. VERHEIJEN, J. H.; E. MULUAART, G. T. G. CHANG, C. KLUFT & G. WIJNGAARDS: A simple, sensitive spectrophotometric assay for extrinsic (tissue type) plasminogen activator applicable to measurements in plasma. Thromb. Haemost. 48: 266-269, 1982
18. TACHIKAWA, K.; K. HASUMI & A. ENDO: Enhancement of plasminogen binding to U937 cells and fibrin by complestatin. Thromb. Haemost. 77: 137-142, 1997
19. INOUE, T.; K. HASUMI, M. SUGIMOTO & A. ENDO: Enhancement of fibrinolysis by plactins: structure-activity relationship and effects in human U937 cells and in mice. Thromb. Haemost. 79: 591-596, 1998
20. OGAWA, K.; M. NAKAMURA, M. HAYASHI, S. YAGINUMA, S. YAMAMOTO, K. FURIHATA, K. SHIN-YA & H. SETO: Stachybocins, novel endothelin receptor antagonists, produced by Stachybotrys sp. M6222. II. Structure determination of stachybocins A, B and C. J. Antibiotics 48: 1396-1400, 1995
21. ROGGO, B. E.; P. HUG, S. MOSS, A. STÄMPFLI, H.-P. KRIEMLER & H. H. PERTER: Novel spirodihydrobenzofuranlactams as antagonists of endothelin and as inhibitors of HIV-1 protease produced by Stachybotrys sp. II. Structure determination. J. Antibiotics 49: 374-379, 1996