Lysine-50 is a likely site for anchoring the plasminogen N-terminal peptide to lysine-binding kringles

Protein Science

Volumn 7, Issue 9, 1998, Pages 1960-1969

  An, Seong Soo A ^a   Carreño, Cristina ^b   Marti, Daniel N ^a   Schaller, Johann ^c   Albericio, Fernando ^b   Llinas, Miguel ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Kringle lysine binding; Plasminogen activation peptide; Plasminogen N terminal peptide; Preactivation peptide loop

Indexed keywords

ARGININE; GLUTAMIC ACID; ISOLEUCINE; LYSINE; N ALPHA ACETYLLYSINE METHYL ESTER; NALPHA ACETYLALANYLPHENYLALANYLTYROSYLHISTIDYLSERYLSERYLLYSYLGLUTAMYLGLUTAMINE AMIDE; PEPTIDE; PLASMINOGEN; SERINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; HUMAN; KRINGLE DOMAIN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SITE DIRECTED MUTAGENESIS;

EID: 0031663680     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560070911     Document Type: Article

References (38)

1. An SSA, Marti D, Carreño C, Albericio F, Schaller J, Llinás M. 1998. Structural/ functional properties of the Glu1-HSer57 N-terminal fragment of human plasminogen: Conformational characterization and interaction with kringle domains. Protein Sci 7:1947-1959.
2. Andreu D, Albericio F, Sole NA, Munson MC, Ferrer M, Barany G. 1994. Peptide synthesis protocols. In: Pennington MW, Dunn BM, eds. Methods in molecular biology, Vol 35. Totowa, NJ: Humana Press. pp 91-169.
3. Aue WP, Bartholdi E, Ernst RR. 1976. Two-dimensional spectroscopy. Application to nuclear magnetic resonance. J Chem Phys 64:2229-2246.
4. Balciunas A, Fless GM, Scanu AM, Copeland RA. 1993. Interactions of a fluorescently labeled peptide with kringle domains in proteins. J Protein Chem 12:39-43.
5. Belczewski AR, Laplaud PM, Chapman MJ, Koschinsky ML. 1996. The complete cDNA sequence encoding plasminogen from the European hedgehog (Erinaceus europaeus). Gene 171:271-274.
6. Berglund L, Andersen MD, Petersen TE. 1995. Cloning and characterization of the bovine plasminogen cDNA. Int Dairy J 5:593-603.
7. Brünger AT. 1988. X-PLOR version 3.3: A system for X-ray crystallography and NMR. New Haven: Yale University Press.
8. 1H-NMR. Biochemistry 34:2739-2750.
9. 1H-NMR analysis of horse plasminogen kringle 4. Chem Phys Lipids 67/68:43-58.
10. Degen SJ, Bell SM, Schaefer LA, Elliott RW. 1990. Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse. Genomics 8:49-61.
11. De Marco A, Petros AM, Laursen RA, Llinás M. 1987. Analysis of ligand-binding to the kringle 4 fragment from human plasminogen. Eur Biophys J 14:359-368.
12. Forsgren M, Råden B, Israelsson M, Larsson K, Hedén L-O. 1987. Molecular cloning and characterization of a full-length cDNA clone for human plasminogen. FEBS Lett 213:254-260.
13. Hochschwender SM, Laursen RA. 1981. The lysine binding sites of human plasminogen: Evidence for a critical tryptophan in the binding site of kringle 4. J Biol Chem 256:11172-11176.
14. Horrevoets AJG, Smilde AE, Fredenburgh JC, Pannekoek H, Nesheim ME. 1995. The activation-resistant conformation of recombinant human plasminogen is stabilized by basic residues in the amino-terminal hinge region. J Biol Chem 270:15770-15776.
15. Ichinose A. 1992. Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. Biochemistry 31:3113-3118.
16. Lawn RM, Boonmark NW, Schwartz K, Lindahl GE, Wade DP, Byrne CD, Fong KJ, Meer K, Patthy L. 1995. The recurring evolution of lipoprotein(a): Insights from cloning of hedgehog apolipoprotein(a). J Biol Chem 270:24004-24009.
17. Lerch PG, Rickli EE, Lergier W, Gillessen D. 1980. Localization of individual lysine binding regions in human plasminogen and investigation on their complex-forming properties. Eur J Biochem 107:7-13.
18. 1H spin-spin coupling constant in proteins. Biochem Biophys Res Commun 113:967-978.
19. Markus G. 1996. Conformational changes in plasminogen, their effect on activation, and the agents that modulate activation rates: A review. Fibrinolysis 10:75-85.
20. 1H-NMR. Biochemistry 36:11591-11604.
21. Marti T, Schaller J, Rickli EE. 1985. Determination of the complete amino acid sequence of porcine miniplasminogen. Eur J Biochem 149:279-285.
22. Rajan N. 1987. Interaction between human fibrin and plasminogen using synthetic peptides as models and the interaction between fibrin and tissue plasminogen activator [Doctoral Dissertation]. Boston University.
23. Ramesh V, Rajan N, Laursen RA, Llinás M. 1995. Plasminogen kringle 4 binds the heptapeptide fragment 44-50 of the plasminogen N-terminal peptide. Blood Coag Fibrinols 6:207-218.
24. Rejante MR, Byeon IJL, Llinás M. 1991. Ligand specificity of human plasminogen kringle 4. Biochemistry 30:11081-11092.
25. Ryan TJ, Keegan MC. 1985. Photoaffinity labeling of functionally different lysine-binding sites in human plasminogen and plasmin. Biochim Biophys Acta 830:187-194.
26. Schaller J, Marti T, Rösselet SJ, Kämpfer U, Rickli EE. 1987. Amino acid sequence of the heavy chain of porcine plasmin. Comparison of the carbohydrate attachment sites with the human and bovine species. Fibrinolysis 1:91-102.
27. Schaller J, Moser PW, Dannegger-Müller GAK, Rösselet SJ, Kämpfer U, Rickli EE. 1985. Complete amino acid sequence of bovine plasminogen: Comparison with human plasminogen. Eur J Biochem 149:267-278.
28. Sjöholm I, Wiman B, Wallén P. 1973. Studies on the conformational changes of plasminogen induced during activation to plasmin and by 6-aminohexanoic acid. Eur J Biochem 30:471-479.
29. 1H NMR characteristics of the kringle (2 + 3) supermodule: Spectroscopic/functional individuality of plasminogen kringle domains. Biochemistry 35:2357-2364.
30. Takada Y, Urano T, Takada A. 1993. Conformational change of plasminoge: Effects of N-terminal peptides of Glu-plasminogen. Thrombosis Res 70:151-159.
31. Tomlinson JE, McLean JW, Lawn RM. 1989. Rhesus monkey apolipoprotein(a): Sequence, evolution, and sites of synthesis. J Biol Chem 264:5957-5965.
32. Urano T, Takada Y, Takada A. 1991. Effects of N-terminal peptide of Gluplasminogen on the activation of Glu-plasminogen and its conversion to Lys-plasminogen. Thrombosis Res 61:349-359.
33. Wallén P. 1980. Biochemistry of plasminogen. In: Kline DL, Reddy KNN, eds. Fibrinolysis. Boca Ratón, Florida: CRC Press. pp 1-24.
34. Weissbach L, Treadwell BV. 1992. A plasminogen-related gene is expressed in cancer cells. Biochem Biophys Res Commun 186:1108-1114.
35. 1H NMR of proteins: Experimental procedures. J Mag Reson 56:207-234.
36. 2-antiplasmin. Fibrinolysis 3:231-235.
37. Wiman B, Collen D. 1978. Molecular mechanism of physiological fibrinolysis. Nature 272:549-550.
38. 2-terminal activation peptide as studied by affinity chromatography. Eur J Biochem 50:489-494.