Effect of Vitamin C Supplementation on Oxidative DNA Damage in an Experimental Model of Lead-Induced Hypertension

Annals of Nutrition and Metabolism

Volumn 47, Issue 6, 2003, Pages 294-301

  Attri, Jyotika ^a   Dhawan, Veena ^a   Mahmood, Safrun ^a   Pandhi, Promila ^a   Parwana, H K ^b   Nath, Ravinder ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b Punjab Pollution Control Board   (India)

Author keywords

Blood pressure; DNA damage; Nitric oxide; Oxidative stress

Indexed keywords

8 HYDROXY 2 DEOXYGUANOSINE; ANTIOXIDANT; ASCORBIC ACID; DEOXYGUANOSINE DERIVATIVE; DNA; FERRIC ION; LEAD; LEAD ACETATE; MALONALDEHYDE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; EXPERIMENTAL MODEL; EXPOSURE; FEEDING; HYPERTENSION; LIPID PEROXIDATION; MALE; MEASUREMENT; METABOLITE; NONHUMAN; OXIDATION; PARAMETER; PATHOGENESIS; PRIORITY JOURNAL; RAT; VITAMIN SUPPLEMENTATION;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; DEOXYADENOSINES; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; DNA DAMAGE; HYPERTENSION; LEAD POISONING; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; NITRIC OXIDE; ORGANOMETALLIC COMPOUNDS; OXIDATION-REDUCTION; RANDOM ALLOCATION; RATS; RATS, INBRED WKY; REACTIVE OXYGEN SPECIES; TIME FACTORS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 1342312240     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000072402     Document Type: Article

References (51)

1. Lacy F, O'Connor D, Schmid-Schonbein G: Plasma hydrogen peroxide production in hypertensives and normotensive subjects of genetic risk of hypertension. J Hypertens 1998;16:291-303.
2. Russo C, Olivieri O, Girelli D, Faccini G, Zenari LM, Lombardi S, Corrocher R: Antioxidant status and lipid peroxidation in patients with essential hypertension. J Hypertens 1998;16:1267-1271.
3. Tagami M, Yamagata K, Ikeda K, Fujino H, Nara Y, Nagakawa K, et al: Genetic vulnerability of cortical neurons isolated from strokeprone spontaneously hypertensive rats in hypoxia and oxygen reperfusion. Hypertens Res 1999;22:23-29.
4. Dhalla NS, Temsah RM, Netticadan T: Role of oxidative stress in cardiovascular diseases. J Hypertens 2000;18:655-673.
5. Vaziri ND, Ding Y: Effect of lead on nitric oxide synthase expression in coronary endothelial cells. Role of superoxide. Hypertension 2001;37:223-227.
6. Gonick HC, Ding Y, Bondy SC, Ni Z, Vaziri ND: Lead induced hypertension. Interplay of nitric oxide and reactive oxygen species. Hypertension 1997;30:1487-1492.
7. Vaziri ND, Ding Y, Ni Z: Nitric oxide synthase expression in the course of lead induced hypertension. Hypertension 1999;34:558-562.
8. Maxwell SRJ: Pospects for the use of antioxidant therapies. Drugs 1995;49:345-361.
9. Roy NK, Rossman TG: Mutagenesis and comutagenesis by lad compounds. Toxicol Appl Pharmacol 1997;142:106-115.
10. Stampfer MJ, Hennekens CH, Manson JE, Colditz Ga,Rosner B, Willet WC: Vitamin E consumption and the risk of coronary heart disease in women. N. Engl. J. Med. 1993;328:1444-1449.
11. Barrie SA, Wright JU, Pizzorno JE: Effect of garlic pill on platelet aggregation, serum lipids and blood pressure in humans. J Ortho Mol Med 1982;2:15-21.
12. Rimm E, Stampfer M, Asherio A, Giovannuci E, Colditz G, Willett W: Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328:1450-1456.
13. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook N, Belanger C, Lamotte F, Gaziano J, Ridker P, Willet W, Peto R: Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 1996;334:1145-1149.
14. Shigenaga M, Gimeno C, Ames B: Urinary 8-hydroxy-2′-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proc Natl Acad Sci USA 1989;86:9697-9701.
15. Wen Y, Killalea S, McGettigan P, Feely J: Lipid peroxidation and antioxidant vitamin C and E in hypertensive patients. Ir J Med Sci 1996;165:210-212.
16. Carr A, Frei B: The role of natural antioxidants in preserving the biological activity of endothelium derived nitric oxide. Free Radic Biol Med 2000;15:1806-1814.
17. Fotherby MD, Williams JC, Forster LA, Craner P, Ferns GA: Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. J Hypertens 2000;18:411-415.
18. Ghosh Mk, Chattopadhyay DJ, Chatterjee IB: Vitamin C prevents oxidative damage. Free Radic Res 1996;25:173-179.
19. Cadenas S, Rojas C, Perez CR: Effect of dietary vitamin C and catalase inhibition of antioxidants and molecular markers of oxidative damage in guinea pigs. Free Radic Res 1994;21:109-118.
20. Crott JW, Fenech M: Effect of vitamin C supplementation on chromosome damage, apoptosis and necrosis ex vivo. Carcinogenesis 1999;20:1035-1041.
21. Cooke MS, Evans MD, Podmore ID, Herbert KE, Mistry N, Mistry P, Hickenbotham PT, Hussieni A, Griffiths HR, Lunec J: Novel repair action of vitamin C upon in vivo oxidative DNA damage. FEBS Lett 1998;439:363-367.
22. 15N] nitrate in biological fluids. Analyt Biochem 1982;126:131-138.
23. Thurnham DI, Smith E, Flaa SP: Concurrent liquid chromatographic assay of retinal, α-tocopherol, β-carotene, β-cryptoxanthin in plasma with tocopherol acetate as internal standard. Clin Chem 1988;34:377-381.
24. Margolis SA, Paule RC, Ziegler RG: Ascorbic and dehydroascorbic acids measured in plasma preserved with dithiothreitol or metaphosphoric acid. Clin Chem 1990;36:1750-1755.
25. Benzie FF, Strain JJ: Ferric reducing/antioxidant power assay: Direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Anal Biochem 1996;239:15-27.
26. Clerc M, Peuchant E, Carbonneau MA, Sess D: Free and bound malondialdehyde measured as thiobarbituric acid adduct by HPLC in serum and plasma. Clin Chem 1991;37/8:1423-1429.
27. Miller DT, Paschal DC, Gunter EW, Strond PE, D'Angelo J: Determination of lead in blood lead using electrothermal automisation atomic absorption spectrometry with a L'vov platform and matrix modifier. Analyst 1987;112:1701-1704.
28. Lahiri DK, Bye S, Nurnberger JL Jr, Hodes ME, Crisp M: A non-organic and non-enzymatic extraction method gives higher yields of genomic DNA from whole-blood samples than do nine other methods tested. J Biochem Biophys Methods 1992;5:193-205.
29. Maniatis T, Sambrook J, Fritch EF: Molecular Cloning: A Laboratory Manual, ed 2. Cold Spring Harbor, Cold Spring Harbor Laboratory Press, 1989, pp 6.3-6.4.
30. Loft S, Vistisen K, Ewertz M, Tjonneland A, Overvad K, Poulsen E: Oxidative DNA damage estimated by 8-hydroxyl-2-deoxyguanine excretion in humans: Influence of smoking, gender and body mass index. Carcinogenesis 1992;13:2241-2247.
31. Zhang D, Okada S,Yu Y, Zheng P, Yamaguchi R, Kasai H: Vitamin E inhibits apoptosis, DNA modification and cancer incidence induced by iron mediated peroxidation in Wistar rat kidney. Cancer Res 1997;57:2410-2414.
32. Hemila B: Establishing the significance and optimal intake of dietary antioxidants: The Biomarker Concept. Nutr Rev 1999;57:104-113.
33. Ness AR, Chee D, Elliot P: Vitamin C and blood pressure, an overview. J Hum Hypertens 1997;11:343-350.
34. Ness AR, Khaw NT, Bingham S, Day NE: Vitamin C status and blood pressure. J Hypertens. 1996;14:503-508.
35. Yoshioka M, Aoyama K, Matsushita T: Effect of ascorbic acid on blood pressure and ascorbic acid metabolism in spontaneously hypertensive rats. Int J Vitam Res 1985;55:301-307.
36. Thomas DM: Reducing blood levels. JAMA 1999;281:2340-2341.
37. Simon JA, Hues ES: Relationship of ascorbic acid to blood lea levels. JAMA 1999;281:2289-2293.
38. Dalley JW, Gupta PK, Lam FC, Hung CT: Interaction of L-ascorbic acid on the disposition of lead in rats. Pharmacol Toxicol 1989;64:360-364.
39. Peraza MA, Ayala Fierro F, Barber DS, Casarez E, Rael LT: Effects of micronutrients on metal toxicity. Environ Health Perspect 1998;106:203-216.
40. Kumar KU, Das UN: Are free radicals involved in the pathophysiology of human essential hypertension? Free Radic Res Commun 1993;19:59-66.
41. Singal PK, Khaper N, Palace U, Kumar D: The role of oxidative stress in the genesis of heart disease. Cardiovasc Res 1998;40:426-432.
42. Frei B: On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Proc Soc Exp Biol Med. 1999;222:196-204.
43. Carr A, Frei B: The role of natural antioxidants in preserving the biological activity of endothelium derived nitric oxide. Free Radic Biol Med 2000;28:1806-1814.
44. Beyer RE: The role of ascorbate in antioxidant protection of biomembranes: Interaction with vitamin E and coenzyme Q. J Biomerg Biomembr 1994;26:349-358.
45. Ding Y, Vaziri ND, Gonick HC: Lead induced hypertension. II: Response to sequential infusions of L-arginine, superoxide dismutase and nitroprusside. Environ Res 1998;76:107-113.
46. Vaziri ND, Ding Y, Gonick HC: Altered nitric oxide metabolism and increased oxygen free radical activity in lead induced hypertension: Effect of lazaroid therapy. Kidney Int 1997;52:1042-1046.
47. Vaziri N, Liang K, Ding Y: Increased NO inactivation by reactive oxygen species in lead induced hypertension. Kidney Int 1999;56:1492-1498.
48. Richter C, Park JW and Ames BN: Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 1988;85:6465-6467.
49. Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN: Oxidative damage to DNA during aging-8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 1990;87:4533-4537.
50. Birnbom HK: The producton of DNA strand breaks in human leucocytes by superoxide radical. Proc Natl Acad Sci USA1985;82:80-88.
51. Inoue S, Kawanishi S: Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide. FEBS Lett 1995;371:86-88.