iNOS homodimerization as a target for potential new therapeutic agents

Drugs of the Future

Volumn 29, Issue 1, 2004, Pages 45-52

  Konno, Fujiko ^a   Ohtsuka, Mari ^a  

^a SSP CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2,4 DIFLUOROPHENYL) 6 [2 [4 (1H IMIDAZOL 1 YLMETHYL)PHENOXY]ETHOXY] 2 PHENYLPYRIDINE; ALPHA INTERFERON; BBS 1; BBS 2; CLOTRIMAZOLE; INDUCIBLE NITRIC OXIDE SYNTHASE; MICONAZOLE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

CATALYSIS; DIMERIZATION; DRUG MECHANISM; ENZYME INHIBITION; MOLECULAR DYNAMICS; NONHUMAN; PATHOPHYSIOLOGY; REVIEW; RHEUMATOID ARTHRITIS; SEPTIC SHOCK; STRUCTURE ACTIVITY RELATION;

EID: 1342312028     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2004.029.01.777834     Document Type: Review

References (44)

1. Hobbs, A.J., Higgs, A., Moncada, S. Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol 1999, 39: 191-220.
2. Nathan, C. Inducible nitric oxide synthase: What difference does it make? J Clin Invest 1997, 100: 2417-23.
3. Stuehr, D.J. Mammalian nitric oxide synthases. Biochim Biophys Acta 1999, 1411: 217-30.
4. Bredt, D.S., Hwang, P.M., Snyder, S.H. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 1990, 347: 768-70.
5. Nakane, M., Schmidt, H.H.H.W., Pollock, J.S., Förstermann, U., Murad, F. Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett 1993, 316: 175-80.
6. O'Dell, T.J., Huang, P.L., Dawson, T.M. et al. Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. Science 1994, 265: 542-6.
7. Clancy, R.M., Amin, A.R., Abramson, S.B. The role on nitric oxide in inflammation and immunity. Arthritis Rheum 1998, 41: 1141-51.
8. Salkowski, C.A., Detore, G., McNally, R., van Rooijen, N., Vogel, S.N. Regulation of inducible nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccharide in vivo: the roles of macrophages, endogenous IFN-γ, and TNF receptor-1-mediated signaling. J Immunol 1997, 158: 905-12.
9. Farrell, A.J., Blake, D.R., Palmer, R.M.J., Moncada, S. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 1992, 51: 1219-22.
10. Sakurai, H., Kohsaka, H., Liu, M.-F. et al. Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides. J Clin Invest 1995, 96: 2357-63.
11. McInnes, I.B., Leung, B.P., Field, M. et al. Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. J Exp Med 1996, 184: 1519-24.
12. G-monomethyl L-arginine. J Exp Med 1994, 179: 651-60.
13. McCartney-Francis, N., Allen J.B., Mizel, D.E. et al. Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med 1993, 178: 749-54.
14. Stefanovic-Racic, M., Meyers, K., Meschter, C., Coffey, J.W., Hoffman, R.A., Evans, C.H. N-Monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats. Arthritis Rheum 1994, 37: 1062-9.
15. Connor, J.R., Manning, P.T., Settle, S.L. et al. Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur J Pharmacol 1995, 273: 15-24.
16. Baek, K.J., Thiel, B.A., Lucas, S., Stuehr, D.J. Macrophage nitric oxide synthase subunits: Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme. J Biol Chem 1993, 268: 21120-9.
17. Xie, Q.-W., Leung, M., Fuortes, M., Sassa, S., Nathan, C. Complementation analysis of mutants of nitric oxide synthase reveals that the active site requires two hemes. Proc Natl Acad Sci USA 1996, 93: 4891-6.
18. Nishida, K., Harrison, D.G., Navas, J.P. et al. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest 1992, 90: 2092-6.
19. Weiner, C.P., Lizasoain, I., Baylis, S.A., Knowles, R.G., Charles, I.G., Moncada, S. Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci USA 1994, 91: 5212-6.
20. Klatt, P., Pfeiffer, S., List, B.M. Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin. J Biol Chem 1996, 271: 7336-42.
21. Rodriguez-Crespo, I., Gerber, N.C., Montellano, O. Endothelial nitric-oxide synthase - Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation. J Biol Chem 1996, 271: 11462-7.
22. Ghosh, D.K., Husam, M.A.-S., Stuehr, D.J. Domains of macrophage NO synthase have divergent roles in forming and stabilizing the active dimeric enzyme. Biochemistry 1996, 35: 1444-9.
23. Siddhanta, U., Presta, A., Fan, B., Wolan, D., Rousseau, D.L., Stuehr, D.J. Domain swapping in inducible nitric-oxide synthase - Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer. J Biol Chem 1998, 273: 18950-8.
24. Ghosh, D.K., Stuehr, D.J. Macrophage NO synthase: Characterization of isolated oxygenase and reductase domains reveals a head-to-head subunit interaction. Biochemistry 1995, 34: 801-7.
25. Venema, R.C., Ju, H., Zou, R., Ryan, J.W., Venema, V.J. Subunit interaction of endothelial nitric-oxide synthase - Comparisons to the neuronal and inducible nitric-oxide synthase isoforms. J Biol Chem 1997, 272: 1276-82.
26. Panda, K., Rosenfeld, R.J., Ghosh, S., Meade, A.L., Getzoff, E.D., Stuehr, D.J. Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III. J Biol Chem 2002, 277: 31020-30.
27. Sennequier, N., Wolan, D., Stuehr, D.J. Antifungal imidazoles block assembly of inducible NO synthase into an active dimer. J Biol Chem 1999, 274: 930-8.
28. McMillan, K., Adler, M., Auld, D.S. et al. Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry. Proc Natl Acad Sci USA 2000, 97: 1506-11.
29. Blasko, E., Glaser, C.B., Devlin, J.J. et al. Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors. J Biol Chem 2002, 277: 295-302.
30. Ohtsuka, M., Konno, F., Honda, H. et al. PPA250, a novel orally effective inhibitor of the dimerization of inducible nitric oxide synthase, exhibits an anti-inflammatory effect in animal models of chronic arthritis. J Pharmacol Exp Ther 2002, 303: 52-7.
31. Konno, F., Honda, H., Ishii, F. et al. Novel anti-inflammatory agents with NO inhibition. 21st Symp Med Chem 10th Annu Meet Div Med Chem (November 28-30, Kyoto) 2001, Abst 2P-24.
32. Stefanovic-Racic, M., Meyers, K., Meschter, C., Coffey, J.W., Hoffman, R.A., Evans, C.H. Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis. J Reumatol 1995, 22: 1922-8.
33. Cannon, G.W., Openshaw, S.J., Hibbs J.B. Jr., Hoidal, J.R., Huecksteadt, T.P., Griffiths, M.M. Nitric oxide production during adjuvant-induced and collagen-induced arthritis. Arthritis Rheum 1996, 39: 1677-84.
34. Vermeire, K., Thielemans, L., Matthys, P., Billiau, A. The effects of NO synthase inhibitors on murine collagen-induced arthritis do not support a role of NO in the protective effect of IFN-γ. J Leukoc Biol 2000, 68: 119-24.
35. Fletcher, D.S., Widmer, W.R., Luell, S. et al. Therapeutic administration of a selective inhibitor of nitric oxide synthase does not ameliorate the chronic inflammation and tissue damage associated with adjuvant-induced arthritis in rats. J Pharmacol Exp Ther 1998, 284: 714-21.
36. Manthey, C.L., Vogel, S.N. The role of cytokines in host responses to endotoxin. Rev Med Microbiol 1992, 3: 72-9.
37. G-monomethyl-L-arginine or indomethacin. J Pharmacol Exp Ther 1995, 272: 452-9.
38. Ochoa, J.B., Udekwu, A.O., Billiar, T.R. et al. Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg 1991, 214: 621-6.
39. Minnard, E.A., Shou, J., Naama, H., Cech, A., Gallagher, H. Daly, J.M. Inhibition of nitric oxide synthesis is detrimental during endotoxemia. Arch Surg 1994, 129: 142-8.
40. Tunçtan, B., Uludag, O., Altug, S., Abacioglu, N. Effects of nitric oxide synthase inhibition in lipopolysaccharide-induced sepsis in mice. Pharmacol Res 1998, 38: 405-11.
41. Wei, X.Q., Charles, I.G., Smith, A. et al. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 1995, 375: 408-11.
42. Ichinose, F., Hatraishi, R., Wu, J.C. A selective inducible nitric oxide synthase dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice. Am J Physiol Heart Cir Physiol 2003, 285: H2524-30.
43. Szabolcs, M.J., Sun, J., Ma, N. et al. Effects of selective inhibitors of nitric oxide synthase-2 dimerization on acute cardiac allograft rejection. Circulation 2002, 106: 2392-6.
44. Enkhbaatar, P., Murakami, K., Shimoda, K. et al. The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury. Am J Respir Crit Care Med 2003, 167: 1021-6.