Complementation analysis of mutants of nitric oxide synthase reveals that the active site requires two hemes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 10, 1996, Pages 4891-4896

  Xie, Qiao Wen ^a   Leung, Mary ^a   Fuortes, Michele ^a   Sassa, Shigeru ^b   Nathan, Carl ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME; MUTANT PROTEIN; NITRIC OXIDE SYNTHASE; TETRAHYDROBIOPTERIN;

ARTICLE; DIMERIZATION; DNA TRANSFECTION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; GEL FILTRATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; KIDNEY EPITHELIUM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING;

ANIMALS; BINDING SITES; CELL LINE; GENETIC COMPLEMENTATION TEST; HEME; HUMANS; MICE; MUTATION; NITRIC OXIDE SYNTHASE; POINT MUTATION; PROTEIN CONFORMATION; SEQUENCE DELETION; TRANSFECTION;

EID: 0030009008     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.10.4891     Document Type: Article

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