Glycosylation of onconase increases its conformational stability and toxicity for cancer cells

Biochemical and Biophysical Research Communications

Volumn 315, Issue 4, 2004, Pages 976-983

  Kim, Byung Moon ^a,c   Kim, Hana ^a   Raines, Ronald T ^b   Lee, Younghoon ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c Seoul National University   (South Korea)

Author keywords

Cancer chemotherapeutic agent; Conformational stability; Cytotoxicity; Glycosylation; Onconase; Pichia pastoris expression system

Indexed keywords

RANPIRNASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME CONFORMATION; ENZYME GLYCOSYLATION; ENZYME STABILITY; ENZYME STRUCTURE; EXPRESSION VECTOR; HUMAN; HUMAN CELL; IC 50; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN EXPRESSION;

PICHIA PASTORIS;

EID: 1342281681     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.01.153     Document Type: Article

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