Mechanism of VEGF-induced uterine venous hyperpermeability

Journal of Vascular Research

Volumn 42, Issue 1, 2005, Pages 47-54

  Celia, Gerard ^a   Osol, George ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

Calcium; Phospholipase C; Pregnancy; Protein kinase C; Rat; Vascular endothelial growth factor; Veno arterial communication; Venous permeability

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CHELERYTHRINE; DEXTRAN; LANTHANUM CHLORIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHOLIPASE C; PROTEIN KINASE C; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; FLUOROMETRY; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SIGNAL TRANSDUCTION; SOLUTE; SURFACE PROPERTY; UTERINE BLOOD VESSEL; VEIN PERMEABILITY;

ANIMALS; CALCIUM; CAPILLARY PERMEABILITY; ESTRENES; FEMALE; NITRIC OXIDE; PREGNANCY; PROTEIN KINASE C; PYRROLIDINONES; RATS; RATS, SPRAGUE-DAWLEY; UTERUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VEINS;

EID: 13244259555     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000082976     Document Type: Article

References (42)

1. Hester RL: Venular-arteriolar diffusion of adenosine in hamster cremaster microcirculation. Am J Physiol 1990;258(6 Pt 2):H1918-H1924.
2. Hester RL: Uptake of metabolites by postcapillary venules: Mechanism for the control of arteriolar diameter. Microvasc Res 1993;46:254-261.
3. Tigno XT, Ley K, Pries AR, Gaehtgens P: Venulo-arteriolar communication and propagated response. A possible mechanism for local control of blood flow. Pflugers Arch 1989;414:450-456.
4. 2 identified as a luteolytic hormone in sheep. Nat New Biol 1972;238:129-134.
5. Ginther OJ: Internal regulation of physiological processes through local venoarterial pathways: A review. J Anim Sci 1974;39:550-564.
6. Celia G, Osol G: Venoarterial communication as a mechanism for localized signaling in the rat uterine circulation. Am J Obstet Gynecol 2002;187:1653-1659.
7. Ni Y, May V, Braas K, Osol G: Pregnancy augments uteroplacental vascular endothelial growth factor gene expression and vasodilator effects. Am J Physiol 1997;273(2 Pt 2):H938-H944.
8. Petraglia F: Endocrine role of the placenta and related membranes. Eur J Endocrinol 1996;135:166-167.
9. Vuorela P, Hatva E, Lymboussaki A, Kaipainen A, Joukov V, Presico MG, Alitalo K, Halmesmaki E: Expression of vascular endothelial growth factor and placenta growth factor in human placenta. Biol Reprod 1997;56:489-494.
10. Bosio PM, Wheeler T, Anthony F, Conroy R, O'Herlihy C, McKenna P: Maternal plasma vascular endothelial growth factor concentrations in normal and hypertensive pregnancies and their relationship to peripheral vascular resistance. Am J Obstet Gynecol 2001;184:146-152.
11. Clark DE, Smith SK, Licence D, Evans AL, Charnock-Jones DS: Comparison of expression patterns for placenta growth factor, vascular endothelial growth factor (VEGF), VEGF-B and VEGF-C in the human placenta throughout gestation. J Endocrinol 1998;159:459-467.
12. Evans P, Wheeler T, Anthony F, Osmond C: Maternal serum vascular endothelial growth factor during early pregnancy. Clin Sci (Lond) 1997;92:567-571.
13. Bates DO, Curry FE: Vascular endothelial growth factor increases hydraulic conductivity of isolated perfused microvessels. Am J Physiol 1996;271(6 Pt 2):H2520-H2528.
14. Bates DO, Heald RI, Curry FE, Williams B: Vascular endothelial growth factor increases Rana vascular permeability and compliance by different signalling pathways. J Physiol 2001;533(Pt 1):263-272.
15. Pocock TM, Williams B, Curry FE, Bates DO: VEGF and ATP act by different mechanisms to increase microvascular permeability and endothelial [Ca(2+)](i). Am J Physiol Heart Circ Physiol 2000;279:H1625-H1634.
16. Wu HM, Yuan Y, Zawieja DC, Tinsley J, Granger HJ: Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability. Am J Physiol 1999;276(2 Pt 2):H535-H542.
17. Pocock TM, Foster RR, Bates DO: Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. Am J Physiol Heart Circ Physiol 2004;286:H1015-H1026.
18. Breslin JW, Pappas PJ, Cerveira JJ, Hobson RW 2nd, Duran WN: VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide. Am J Physiol Heart Circ Physiol 2003;284:H92-H100.
19. Fukumura D, Gohongi T, Kadambi A, Izumi Y, Ang J, Yun CO, Buerk DG, Huang PL, Jain RK: Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci USA 2001;98:2604-2609.
20. Bates DO, Curry FE: Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway. Am J Physiol 1997;273(2 Pt 2):H687-H694.
21. Osol G, Cipolla M: Pregnancy-induced changes in the three-dimensional mechanical properties of pressurized rat uteroplacental (radial) arteries. Am J Obstet Gynecol 1993;168(1 Pt 1):268-274.
22. Nienartowicz A, Link S, Moll W: Adaptation of the uterine arcade in rats to pregnancy. J Dev Physiol 1989;12:101-108.
23. Page KL, Celia G, Leddy G, Taatjes DJ, Osol G: Structural remodeling of rat uterine veins in pregnancy. Am J Obstet Gynecol 2002;187:1647-1652.
24. Osol G, Halpern W: Myogenic properties of cerebral blood vessels from normotensive and hypertensive rats. Am J Physiol 1985;249(5 Pt 2):H914-H921.
25. Halpern W, Osol G, Coy GS: Mechanical behavior of pressurized in vitro prearteriolar vessels determined with a video system. Ann Biomed Eng 1984;12:463-479.
26. Lakshminarayanan S, Antonetti DA, Gardner TW, Tarbell JM: Effect of VEGF on retinal microvascular endothelial hydraulic conductivity: The role of NO. Invest Ophthalmol Vis Sci 2000;41:4256-4261.
27. Ferrara N, Gerber HP, LeCouter J: The biology of VEGF and its receptors. Nat Med 2003;9:669-676.
28. Bates DO, Hillman NJ, Williams B, Neal CR, Pocock TM: Regulation of microvascular permeability by vascular endothelial growth factors. J Anat 2002;200:581-597.
29. Rebecchi MJ, Pentyala SN: Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol Rev 2000;80:1291-1335.
30. Quest AF: Regulation of protein kinase C: A tale of lipids and proteins. Enzyme Protein 1996;49:231-261.
31. Dudek SM, Garcia JG: Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 2001;91:1487-1500.
32. Garcia JG, Davis HW, Patterson CE: Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation. J Cell Physiol 1995;163:510-522.
33. Bogatcheva NV, Garcia JG, Verin AD: Molecular mechanisms of thrombin-induced endothelial cell permeability. Biochemistry (Mosc) 2002;67:75-84.
34. Fleming I, Bauersachs J, Busse R: Calcium-dependent and calcium-independent activation of the endothelial NO synthase. J Vasc Res 1997;34:165-174.
35. Wu KK: Regulation of endothelial nitric oxide synthase activity and gene expression. Ann NY Acad Sci 2002;962:122-130.
36. Schneeberger EE, Lynch RD: Structure, function, and regulation of cellular tight junctions. Am J Physiol 1992;262(6 Pt 1):L647-L661.
37. Ni Y, Meyer M, Osol G: Gestation increases nitric oxide-mediated vasodilation in rat uterine arteries. Am J Obstet Gynecol 1997;176:856-864.
38. Al-Naemi H, Baldwin AL: Nitric oxide protects venules against histamine-induced leaks. Microcirculation 2000;7:215-223.
39. Mayhan WG: VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway. Am J Physiol 1999;276(5 Pt 1):C1148-C1153.
40. Baldwin AL, Thurston G, Al Naemi H: Inhibition of nitric oxide synthesis increases venular permeability and alters endothelial actin cytoskeleton. Am J Physiol 1998;274(5 Pt 2):H1776-H1784.
41. Poston L, McCarthy AL, Ritter JM: Control of vascular resistance in the maternal and fetoplacental arterial beds. Pharmacol Ther 1995;65:215-239.
42. Graf AH, Hutter W, Hacker GW, Steiner H, Anderson V, Staudach A, Dietze O: Localization and distribution of vasoactive neuropeptides in the human placenta. Placenta 1996;17:413-421.