Differential expression of matrix metalloproteinases and cyclooxygenases in synovial cells exposed to Borrelia burgdorferi

Inflammation Research

Volumn 53, Issue 12, 2004, Pages 689-696

  Singh, S K ^a   Morbach, H ^a   Nanki, T ^b   Faber, C ^a   Baar, V ^a   Girschick, H J ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Borrelia burgdorferi; Cyclooxygenases; Inflammation; Metalloproteinases; Pathogen host interaction

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; MATRIX METALLOPROTEINASE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ARTICLE; BACTERIAL STRAIN; BORRELIA BURGDORFERI; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; LYME DISEASE; MOLECULAR BIOLOGY; NONHUMAN; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; SYNOVIOCYTE; UPREGULATION;

BORRELIA BURGDORFERI; CELLS, CULTURED; COLLAGENASES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; RNA, MESSENGER; SYNOVIAL FLUID;

EID: 12944302109     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00011-004-1313-x     Document Type: Article

References (39)

1. Steere AC, Duray PH, Butcher EC. Spirochetal antigens and lymphoid cell surface markers in Lyme synovitis. Comparison with rheumatoid synovium and tonsillar lymphoid tissue. Arthritis Rheum 1988; 31: 487-95.
2. Singh SK, Girschick, HJ. Tick-host interactions and their immunological implications in tick-borne diseases. Current Science 2003; 85: 101-15.
3. Georgilis K, Peacocke M, Klempner MS. Fibroblasts protect the Lyme disease spirochete, Borrelia burgdorferi, from ceftriaxone in vitro. J Infect Dis 1992; 166: 440-4.
4. Girschick HJ, Huppertz HI, Russmann H, Krenn V, Karch H. Intracellular persistence of Borrelia burgdorferi in human synovial cells. Rheumatol Int 1996; 16: 125-32.
5. Singh SK, Girschick HJ. Lyme borreliosis: from infection to autoimmunity. Clin Microbiol Infect 2004; 10: 598-614.
6. Girschick HJ, Meister S, Karch H, Huppertz HI. Borrelia burgdorferi downregulates ICAM-1 on human synovial cells in vitro. Cell Adhes Commun 1999; 7: 73-83.
7. Schwaiger M, Peter O, Cassinotti P. Routine diagnosis of Borrelia burgdorferi (sensu lato) infections using real-time PCR assay. Clin Microbiol Infect 2001; 7: 461-9.
8. Steere AC, Duray PH, Butcher EC. Spirochetal antigens and lymphoid cell surface markers in Lyme synovitis. Comparison with rheumatoid synovium and tonsillar lymphoid tissue. Arthritis Rheum 1988; 31: 487-95.
9. Kriegsmann J, Keyszer GM, Geiler T, Brauer R, Gay RE, Gay S. Expression of vascular cell adhesion molecule-1 mRNA and protein in rheumatoid synovium demonstrated by in situ hybridization and immunohistochemistry. Lab Invest 1995; 72: 209-14.
10. Pelletier JP, Faure MP, DiBattista JA, Wilhelm S, Visco D, Martel-Pelletier J. Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis. An immunohistochemical study. Am J Pathol 1993; 142: 95-105.
11. Szekanecz Z, Kim T, Koch AE. Chemokines and chemokine receptors in rheumatoid arthritis. Semin Immunol 2003; 15: 15-21.
12. Anguita J, Samanta S, Ananthanarayanan SK, Revilla B, Geba GP, Barthold SW et al. Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis. FEMS Immunol Med Microbiol 2002; 34: 187-91.
13. Gebbia JA, Coleman JL, Benach JL. Borrelia spirochetes upregulate release and activation of matrix metalloproteinase gelatinase B (MMP-9) and collagenase 1 (MMP-1) in human cells. Infect Immun 2001; 69: 456-62.
14. Hu LT, Eskildsen MA, Masgala C, Steere AC, Arner EC, Pratta MA et al. Host metalloproteinases in Lyme arthritis. Arthritis Rheum 2001; 44: 1401-10.
15. Masferrer JL, Isakson PC, Seibert K. Cyclooxygenase-2 inhibitors: a new class of anti-inflammatory agents that spare the gastrointestinal tract. Gastroenterol Clin North Am 1996; 25: 363-72.
16. Warner TD, Mitchell JA. Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum? Proc Natl Acad Sci USA 2002; 99: 13371-3.
17. Huppertz HI. How could infectious agents hide in synovial cells? Possible mechanisms of persistent viral infection in a model for the etiopathogenesis of chronic arthritis. Rheumatol Int 1994; 14: 71-5.
18. Gassmann GS, Kramer M, Gobel UB, Wallich R. Nucleotide sequence of a gene encoding the Borrelia burgdorferi flagellin. Nucleic Acids Res 1989; 17: 3590.
19. Girschick HJ, Grammer AC, Nanki T, Mayo M, Lipsky PE. RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral blood. J Immunol 2001; 166: 377-86.
20. Nanki T, Hayashida K, El-Gabalawy HS, Suson S, Shi K, Girschick HJ et al. Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis synovium. J Immunol 2000; 165: 6590-8.
21. Donner A, Eliasziw M. Application of matched pair procedures to site-specific data in periodontal research. J Clin Periodontol 1991; 18: 755-9.
22. Steere AC. [Lyme arthritis: the joint lesions in Lyme borreliosis in the USA]. Ter Arkh 1995; 67: 43-5.
23. Nanagara R, Duray PH, Schumacher HR Jr. Ultrastructural demonstration of spirochetal antigens in synovial fluid and synovial membrane in chronic Lyme disease: possible factors contributing to persistence of organisms. Hum Pathol 1996; 27: 1025-34.
24. Chary-Valckenaere I, Jaulhac B, Champigneulle J, Piemont Y, Mainard D, Pourel J. Ultrastructural demonstration of intracellular localization of Borrelia burgdorferi in Lyme arthritis. Br J Rheumatol 1998; 37: 468-70.
25. Vincenti MP, Brinckerhoff CE. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res 2002; 4: 157-64.
26. Lin B, Kidder JM, Noring R, Steere AC, Klempner MS, Hu LT. Differences in synovial fluid levels of matrix metalloproteinases suggest separate mechanisms of pathogenesis in Lyme arthritis before and after antibiotic treatment. J Infect Dis 2001; 184: 174-80.
27. Smeets TJ, Barg EC, Kraan MC, Smith MD, Breedveld FC, Tak PP. Analysis of the cell infiltrate and expression of proinflammatory cytokines and matrix metalloproteinases in arthroscopic synovial biopsies: comparison with synovial samples from patients with end stage, destructive rheumatoid arthritis. Ann Rheum Dis 2003; 62: 635-8.
28. Parente L, Perretti M. Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. Biochem Pharmacol 2003; 65: 153-9.
29. Crofford LJ, Wilder RL, Ristimaki AP, Sano H, Remmers EF, Epps HR et al. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J Clin Invest 1994; 93: 1095-101.
30. Crofford LJ. COX-2 in synovial tissues. Osteoarthritis Cartilage 1999; 7: 406-8.
31. Simon LS. Role and regulation of cyclooxygenase-2 during inflammation. Am J Med 1999; 106: 37S-42S.
32. Anderson GD, Hauser SD, McGarity KL, Bremer ME, Isakson PC, Gregory SA. Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J Clin Invest 1996; 97: 2672-9.
33. Raisz LG, Fall PM. Biphasic effects of prostaglandin E2 on bone formation in cultured fetal rat calvariae: interaction with cortisol. Endocrinology 1990; 126: 1654-9.
34. Bunning RA, Russell RG. The effect of tumor necrosis factor alpha and gamma-interferon on the resorption of human articular cartilage and on the production of prostaglandin E and of caseinase activity by human articular chondrocytes. Arthritis Rheum 1989; 32: 780-4.
35. Crofford LJ, Tan B, McCarthy CJ, Hla T. Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes. Arthritis Rheum 1997; 40: 226-36.
36. Radolf JD, Norgard MV, Brandt ME, Isaacs RD, Thompson PA, Beutler B. Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct. J Immunol 1991; 147: 1968-74.
37. Miller LC, Isa S, Vannier E, Georgilis K, Steere AC, Dinarello CA. Live Borrelia burgdorferi preferentially activate interleukin-1 beta gene expression and protein synthesis over the interleukin-1 receptor antagonist. J Clin Invest 1992; 90: 906-12.
38. Ma Y, Seiler KP, Tai K, Yang L, Woods M, Weis JJ. Outer surface lipoproteins of Borrelia burgdorferi stimilate nitric oxide production by the cytokine inducible pathway. Infect Immun 1994; 62: 3663-71.
39. Pillinger MH, Rosenthal PB, Tolani SN, Apsel B, Dinsell V, Greenberg J et al. Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activation. J Immunol 2003; 171: 6080-9.