Virtual screening for kinase targets

Current Medicinal Chemistry

Volumn 11, Issue 6, 2004, Pages 693-707

  Muegge, Ingo ^a   Enyedy, Istvan J ^b  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b BAYER CORPORATION   (United States)

Author keywords

ATP binding pocket; Computational chemistry; Database searching; Lead idientification; Rational drug design

Indexed keywords

ADENOSINE TRIPHOSPHATE; B 17; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 4; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; THYMIDINE KINASE; UNCLASSIFIED DRUG;

BREAST CANCER; CANCER CELL CULTURE; COMPETITIVE INHIBITION; COMPUTER ANALYSIS; COMPUTER MODEL; COMPUTER PROGRAM; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; INTERMETHOD COMPARISON; MULTIGENE FAMILY; PROTEIN DATABASE; PROTEIN TARGETING; REVIEW; SCORING SYSTEM; SEQUENCE HOMOLOGY; SRC HOMOLOGY DOMAIN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIRTUAL REALITY;

BINDING SITES; DATABASES, PROTEIN; DRUG DESIGN; ENZYME INHIBITORS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RECEPTOR, ERBB-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1642378145     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867043455684     Document Type: Review

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