-
1
-
-
0035025460
-
Gastrointestinal stromal tumors and leiomyosarcoma of the abdomen and retroperitoneum: A clinical comparison
-
Clary BM, DeMatteo RP, Lewis JJ, et al. Gastrointestinal stromal tumors and leiomyosarcoma of the abdomen and retroperitoneum: a clinical comparison. Ann Surg Oncol. 2001;8:290-299.
-
(2001)
Ann Surg Oncol
, vol.8
, pp. 290-299
-
-
Clary, B.M.1
DeMatteo, R.P.2
Lewis, J.J.3
-
2
-
-
0013383136
-
Incidence, prevalence, phenotype and biologic sectrum of gastrointestinal stromal cell tumors (GIST): A population-based study of 600 cases
-
Abstract 5770
-
KindBlom LG, Meis-Kindblom JM, Bumming P. Incidence, prevalence, phenotype and biologic sectrum of gastrointestinal stromal cell tumors (GIST): a population-based study of 600 cases. Ann Oncol. 2002;13(suppl 5):157. Abstract 5770.
-
(2002)
Ann Oncol
, vol.13
, Issue.SUPPL. 5
, pp. 157
-
-
KindBlom, L.G.1
Meis-Kindblom, J.M.2
Bumming, P.3
-
3
-
-
0020514752
-
Gastric stromal tumors. Reappraisal of histogenesis
-
Mazur MT, Clark HB. Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol. 1983;7:507-519.
-
(1983)
Am J Surg Pathol
, vol.7
, pp. 507-519
-
-
Mazur, M.T.1
Clark, H.B.2
-
4
-
-
15644363454
-
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
-
Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998;279:577-580.
-
(1998)
Science
, vol.279
, pp. 577-580
-
-
Hirota, S.1
Isozaki, K.2
Moriyama, Y.3
-
5
-
-
0017736213
-
The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma
-
Carney JA, Sheps SG, Go VL, et al. The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma. N Engl J Med. 1977;296:1517-1518.
-
(1977)
N Engl J Med
, vol.296
, pp. 1517-1518
-
-
Carney, J.A.1
Sheps, S.G.2
Go, V.L.3
-
6
-
-
0033064974
-
Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney Triad): Natural history, adrenocortical component, and possible familial occurrence
-
Carney JA. Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney Triad): natural history, adrenocortical component, and possible familial occurrence. Mayo Clinic Proc. 1999;74:543-552.
-
(1999)
Mayo Clinic Proc
, vol.74
, pp. 543-552
-
-
Carney, J.A.1
-
7
-
-
0036240932
-
Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene
-
Hirota S, Nishida T, Isozaki K, et al. Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene. Gastroenterology. 2002;122:1493-1499.
-
(2002)
Gastroenterology
, vol.122
, pp. 1493-1499
-
-
Hirota, S.1
Nishida, T.2
Isozaki, K.3
-
8
-
-
0035174752
-
Familial gastrointestinal stromal tumor with hyperpigmentation: Association with a germline mutation of the c-kit gene
-
Maeyama H, Hidaka E, Ota H, et al. Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene. Gastroenterology. 2001;120:210-215.
-
(2001)
Gastroenterology
, vol.120
, pp. 210-215
-
-
Maeyama, H.1
Hidaka, E.2
Ota, H.3
-
9
-
-
0033971263
-
Cause of familial and multiple gastrointestinal autonomic nerve tumors with hyperplasia of interstitial cells of Cajal is germline mutation of the c-kit gene
-
Hirota S, Okazaki T, Kitamura Y, et al. Cause of familial and multiple gastrointestinal autonomic nerve tumors with hyperplasia of interstitial cells of Cajal is germline mutation of the c-kit gene. Am J Surg Pathol. 2000;24:326-327.
-
(2000)
Am J Surg Pathol
, vol.24
, pp. 326-327
-
-
Hirota, S.1
Okazaki, T.2
Kitamura, Y.3
-
10
-
-
0033678402
-
Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors
-
Isozaki K, Terris B, Belghiti J, et al. Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors. Am J Pathol. 2000;157:1581-1585.
-
(2000)
Am J Pathol
, vol.157
, pp. 1581-1585
-
-
Isozaki, K.1
Terris, B.2
Belghiti, J.3
-
11
-
-
0031848146
-
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene
-
Nishida T, Hirota S, Taniguchi M, et al. Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nat Genet. 1998;19:323-324.
-
(1998)
Nat Genet
, vol.19
, pp. 323-324
-
-
Nishida, T.1
Hirota, S.2
Taniguchi, M.3
-
12
-
-
0038246525
-
Gastrointestinal stromal tumors (GIST): C-kit mutations, CD117 expression, differential diagnosis and targeted cancer therapy with Imatinib
-
Epub 2003 Apr 18
-
de Silva CM, Reid R. Gastrointestinal stromal tumors (GIST): C-kit mutations, CD117 expression, differential diagnosis and targeted cancer therapy with Imatinib. Pathol Oncol Res. 2003;9:13-19. Epub 2003 Apr 18.
-
(2003)
Pathol Oncol Res
, vol.9
, pp. 13-19
-
-
De Silva, C.M.1
Reid, R.2
-
13
-
-
0036081738
-
Diagnosis of gastrointestinal stromal tumors: A consensus approach
-
Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Intl J Surg Pathol. 2002;10:81-89.
-
(2002)
Intl J Surg Pathol
, vol.10
, pp. 81-89
-
-
Fletcher, C.D.1
Berman, J.J.2
Corless, C.3
-
14
-
-
0034109008
-
Extragastrointestinal (soft tissue) stromal tumors: An analysis of 48 cases with emphasis on histologic predictors of outcome
-
Reith JD, Goldblum JR, Lyles RH, et al. Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 2000;13:577-585.
-
(2000)
Mod Pathol
, vol.13
, pp. 577-585
-
-
Reith, J.D.1
Goldblum, J.R.2
Lyles, R.H.3
-
15
-
-
0032862462
-
Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: Clinicopathologic and immunohistochemical study of 26 cases
-
Miettinen M, Monihan JM, Sarlomo-Rikala M, et al. Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 1999;23:1109-1118.
-
(1999)
Am J Surg Pathol
, vol.23
, pp. 1109-1118
-
-
Miettinen, M.1
Monihan, J.M.2
Sarlomo-Rikala, M.3
-
16
-
-
0027218845
-
From white spots to stem cells: The role of the Kit receptor in mammalian development
-
Fleischman RA. From white spots to stem cells: the role of the Kit receptor in mammalian development. Trends Genet. 1993;9:285-290.
-
(1993)
Trends Genet
, vol.9
, pp. 285-290
-
-
Fleischman, R.A.1
-
17
-
-
0031983950
-
Developmental origin and Kit-dependent development of the interstitial cells of cajal in the mammalian small intestine
-
Kluppel M, Huizinga JD, Malysz J, et al. Developmental origin and Kit-dependent development of the interstitial cells of cajal in the mammalian small intestine. Dev Dyn. 1998;211:60-71.
-
(1998)
Dev Dyn
, vol.211
, pp. 60-71
-
-
Kluppel, M.1
Huizinga, J.D.2
Malysz, J.3
-
18
-
-
0034083341
-
KIT expression in angiosarcomas and fetal endothelial cells: Lack of mutations of exon 11 and exon 17 of C-kit
-
Miettinen M, Sarlomo-Rikala M, Lasota J. KIT expression in angiosarcomas and fetal endothelial cells: lack of mutations of exon 11 and exon 17 of C-kit. Mod Pathol. 2000;13:536-541.
-
(2000)
Mod Pathol
, vol.13
, pp. 536-541
-
-
Miettinen, M.1
Sarlomo-Rikala, M.2
Lasota, J.3
-
19
-
-
0028908814
-
Gastrointestinal stromal tumors - Value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas
-
Miettinen M, Virolainen M, Maarit-Sarlomo-Rikala. Gastrointestinal stromal tumors - value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas. Am J Surg Pathol. 1995;19:207-216.
-
(1995)
Am J Surg Pathol
, vol.19
, pp. 207-216
-
-
Miettinen, M.1
Virolainen, M.2
Maarit-Sarlomo-Rikala3
-
20
-
-
0031857113
-
CD117: A sensitive marker for gastrointestinal stromal tumors that is more specific than CD34
-
Sarlomo-Rikala M, Kovatich AJ, Barusevicius A, et al. CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol. 1998;11:728-734.
-
(1998)
Mod Pathol
, vol.11
, pp. 728-734
-
-
Sarlomo-Rikala, M.1
Kovatich, A.J.2
Barusevicius, A.3
-
21
-
-
77349088576
-
Correlation of immunophenotype with clinical outcome of GIST patients treated with imatinib mesylate
-
November 6-8, Barcelona
-
Chirieac L, Trent J, Steinert DM, et al. Correlation of immunophenotype with clinical outcome of GIST patients treated with imatinib mesylate. Presented at the 9th Annual Connective Tissue Oncology Society, November 6-8, 2003, Barcelona.
-
(2003)
9th Annual Connective Tissue Oncology Society
-
-
Chirieac, L.1
Trent, J.2
Steinert, D.M.3
-
22
-
-
0035072108
-
Are desmoid tumors kit positive?
-
Miettinen M. Are desmoid tumors kit positive? Am J Surg Pathol. 2001;25:549-550.
-
(2001)
Am J Surg Pathol
, vol.25
, pp. 549-550
-
-
Miettinen, M.1
-
23
-
-
0026598711
-
Prognostic factors influencing survival in gastrointestinal leiomyosarcomas: Implications for surgical management and staging
-
Ng EH, Pollock RE, Munsell MF, et al. Prognostic factors influencing survival in gastrointestinal leiomyosarcomas: implications for surgical management and staging. Ann Surg. 1992;215:68-77.
-
(1992)
Ann Surg
, vol.215
, pp. 68-77
-
-
Ng, E.H.1
Pollock, R.E.2
Munsell, M.F.3
-
24
-
-
0034885451
-
p53 expression in gastrointestinal stromal tumors
-
Al-Bozom IA. p53 expression in gastrointestinal stromal tumors. Pathol Int 2001;51:519-523.
-
(2001)
Pathol Int
, vol.51
, pp. 519-523
-
-
Al-Bozom, I.A.1
-
25
-
-
0036329780
-
Gastrointestinal stromal tumor: Consistent CD117 immunostaining for diagnosis, and prognostic classification based on tumor size and MIB-1 grade
-
Hasegawa T, Matsuno Y, Shimoda T, et al. Gastrointestinal stromal tumor: consistent CD117 immunostaining for diagnosis, and prognostic classification based on tumor size and MIB-1 grade. Hum Pathol. 2002;33:669-676.
-
(2002)
Hum Pathol
, vol.33
, pp. 669-676
-
-
Hasegawa, T.1
Matsuno, Y.2
Shimoda, T.3
-
26
-
-
0344375087
-
Expression of vascular endothelial growth factor and angiogenesis in gastrointestinal stromal tumor of the stomach
-
Takahashi R, Tanaka S, Kitadai Y, et al. Expression of vascular endothelial growth factor and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncology. 2003;64:266-274.
-
(2003)
Oncology
, vol.64
, pp. 266-274
-
-
Takahashi, R.1
Tanaka, S.2
Kitadai, Y.3
-
27
-
-
0038135029
-
High prognostic value of p16INK4 alterations in gastrointestinal stromal tumors
-
Schneider-Stock R, Boltze C, Lasota J, et al. High prognostic value of p16INK4 alterations in gastrointestinal stromal tumors. J Clin Oncol. 2003;21:1688-1697.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1688-1697
-
-
Schneider-Stock, R.1
Boltze, C.2
Lasota, J.3
-
28
-
-
0033199890
-
Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors
-
Taniguchi M, Nishida T, Hirota S, et al. Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors. Cancer Res. 1999;59:4297-4300.
-
(1999)
Cancer Res
, vol.59
, pp. 4297-4300
-
-
Taniguchi, M.1
Nishida, T.2
Hirota, S.3
-
29
-
-
0032953812
-
Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas
-
Lasota J, Jasinski M, Sarlomo-Rikala M, et al. Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas. Am J Pathol. 1999;154:53-60.
-
(1999)
Am J Pathol
, vol.154
, pp. 53-60
-
-
Lasota, J.1
Jasinski, M.2
Sarlomo-Rikala, M.3
-
30
-
-
0036092268
-
KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size
-
Corless CL, McGreevey L, Haley A, et al. KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size. Am J Pathol. 2002;160:1567-1572.
-
(2002)
Am J Pathol
, vol.160
, pp. 1567-1572
-
-
Corless, C.L.1
McGreevey, L.2
Haley, A.3
-
31
-
-
0035890740
-
KIT activation is a u7biquitous feature of gastrointestinal stromal tumors
-
Rubin BP, Singer S, Tsao C, et al. KIT activation is a u7biquitous feature of gastrointestinal stromal tumors. Cancer Res. 2001;61:8118-8121.
-
(2001)
Cancer Res
, vol.61
, pp. 8118-8121
-
-
Rubin, B.P.1
Singer, S.2
Tsao, C.3
-
32
-
-
9544254849
-
Ras signaling in tumor necrosis factor-induced apoptosis
-
Trent JC II, McConkey DJ, Loughlin SM, et al. Ras signaling in tumor necrosis factor-induced apoptosis. EMBO J. 1996;15:4497-4505.
-
(1996)
EMBO J
, vol.15
, pp. 4497-4505
-
-
Trent II, J.C.1
McConkey, D.J.2
Loughlin, S.M.3
-
33
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2000;103:211-225.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
34
-
-
0023701589
-
c-kit protein, a transmembrane kinase: Identification in tissues and characterization
-
Majumder S, Brown K, Qiu FH, et al. c-kit protein, a transmembrane kinase: identification in tissues and characterization. Mol Cell Biol. 1988;8:4896-4903.
-
(1988)
Mol Cell Biol
, vol.8
, pp. 4896-4903
-
-
Majumder, S.1
Brown, K.2
Qiu, F.H.3
-
36
-
-
0026039464
-
Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis
-
Blume-Jensen P, Claesson-Welsh L, Siegbahn A, et al. Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. Embo J. 1991;10:4121-4128.
-
(1991)
Embo J
, vol.10
, pp. 4121-4128
-
-
Blume-Jensen, P.1
Claesson-Welsh, L.2
Siegbahn, A.3
-
37
-
-
0029101721
-
Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats
-
Isozaki K, Hirota S, Nakama A, et al. Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats. Gastroenterology. 1995;109:456-464.
-
(1995)
Gastroenterology
, vol.109
, pp. 456-464
-
-
Isozaki, K.1
Hirota, S.2
Nakama, A.3
-
38
-
-
0027359443
-
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
-
Furitsu T, Tsujimura T, Tono T, et al. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest. 1993;92:1736-1744.
-
(1993)
J Clin Invest
, vol.92
, pp. 1736-1744
-
-
Furitsu, T.1
Tsujimura, T.2
Tono, T.3
-
39
-
-
0025891543
-
The Steel/W transduction pathway: Kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor
-
Rottapel R, Reedijk M, Williams DE, et al. The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. Mol Cell Biol. 1991;11:3043-3051.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 3043-3051
-
-
Rottapel, R.1
Reedijk, M.2
Williams, D.E.3
-
40
-
-
0028148266
-
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
-
Tauchi T, Feng GS, Marshall MS, et al. The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. J Biol Chem. 1994;269:25206-25211.
-
(1994)
J Biol Chem
, vol.269
, pp. 25206-25211
-
-
Tauchi, T.1
Feng, G.S.2
Marshall, M.S.3
-
41
-
-
0034548829
-
Differential stimulation of c-Kit mutants by membrane-bound and soluble Steel Factor correlates with leukemic potential
-
Gommerman JL, Sittaro D, Klebasz NZ, et al. Differential stimulation of c-Kit mutants by membrane-bound and soluble Steel Factor correlates with leukemic potential. Blood. 2000;96:3734-3742.
-
(2000)
Blood
, vol.96
, pp. 3734-3742
-
-
Gommerman, J.L.1
Sittaro, D.2
Klebasz, N.Z.3
-
42
-
-
0027485538
-
Multiple cytokines induce the tyrosine phosphorylation of She and its association with Grb2 in hemopoietic cells
-
Cutler RL, Liu L, Damen JE, et al. Multiple cytokines induce the tyrosine phosphorylation of She and its association with Grb2 in hemopoietic cells. J Biol Chem. 1993;268:21463-21465.
-
(1993)
J Biol Chem
, vol.268
, pp. 21463-21465
-
-
Cutler, R.L.1
Liu, L.2
Damen, J.E.3
-
43
-
-
0026066984
-
A specific combination of substrates is involved in signal transduction by the kit-encoded receptor
-
Lev S, Givol D, Yarden Y. A specific combination of substrates is involved in signal transduction by the kit-encoded receptor. EMBO J. 1991;10:647-654.
-
(1991)
EMBO J
, vol.10
, pp. 647-654
-
-
Lev, S.1
Givol, D.2
Yarden, Y.3
-
44
-
-
0027280226
-
Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand
-
Yi T, Ihle JN. Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand. Mol Cell Biol. 1993;13:3350-3358.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 3350-3358
-
-
Yi, T.1
Ihle, J.N.2
-
45
-
-
0027965243
-
Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C
-
Blume-Jensen P, Ronnstrand L, Gout I, et al. Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C. J Biol Chem. 1994;269:21793-21802.
-
(1994)
J Biol Chem
, vol.269
, pp. 21793-21802
-
-
Blume-Jensen, P.1
Ronnstrand, L.2
Gout, I.3
-
46
-
-
0036303804
-
Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
-
Heinrich MC, Rubin BP, Longley BJ, et al. Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Hum Pathol. 2002;33:484-495.
-
(2002)
Hum Pathol
, vol.33
, pp. 484-495
-
-
Heinrich, M.C.1
Rubin, B.P.2
Longley, B.J.3
-
47
-
-
0031791026
-
A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors
-
Nakahara M, Isozaki K, Hirota S, et al. A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors. Gastroenterology. 1998;115:1090-1095.
-
(1998)
Gastroenterology
, vol.115
, pp. 1090-1095
-
-
Nakahara, M.1
Isozaki, K.2
Hirota, S.3
-
48
-
-
0037106370
-
Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors
-
Singer S, Rubin BP, Lux ML, et al. Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors. J Clin Oncol. 2002;20:3898-3905.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3898-3905
-
-
Singer, S.1
Rubin, B.P.2
Lux, M.L.3
-
49
-
-
0642368571
-
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
-
Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol. 2003;21:4342-4349.
-
(2003)
J Clin Oncol
, vol.21
, pp. 4342-4349
-
-
Heinrich, M.C.1
Corless, C.L.2
Demetri, G.D.3
-
50
-
-
12144291080
-
Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group
-
Debiec-Rychter M, Dumez H, Judson I, et al. Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer. 2004;40:689-695.
-
(2004)
Eur J Cancer
, vol.40
, pp. 689-695
-
-
Debiec-Rychter, M.1
Dumez, H.2
Judson, I.3
-
51
-
-
0033532190
-
Inhibition of spontaneous receptor phosphorylation by residues in a putative alpha-helix in the KIT intracellular juxtamembrane region
-
Ma Y, Cunningham ME, Wang X, et al. Inhibition of spontaneous receptor phosphorylation by residues in a putative alpha-helix in the KIT intracellular juxtamembrane region. J Biol Chem. 1999;274:13399-13402.
-
(1999)
J Biol Chem
, vol.274
, pp. 13399-13402
-
-
Ma, Y.1
Cunningham, M.E.2
Wang, X.3
-
52
-
-
20844460619
-
A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors
-
Chen LL, Trent JC, Wu EF, et al. A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res. 2004;64:5913-5919.
-
(2004)
Cancer Res
, vol.64
, pp. 5913-5919
-
-
Chen, L.L.1
Trent, J.C.2
Wu, E.F.3
-
53
-
-
0016709236
-
Adriamycin (NSC-123127) used alone and in combination for soft tissue and bony sarcomas
-
Gottlieb JA, Baker LH, O'Bryan RM, et al. Adriamycin (NSC-123127) used alone and in combination for soft tissue and bony sarcomas. Cancer Chemother Rep Part 3. 1975;6:271-282.
-
(1975)
Cancer Chemother Rep Part 3
, vol.6
, pp. 271-282
-
-
Gottlieb, J.A.1
Baker, L.H.2
O'Bryan, R.M.3
-
54
-
-
0344667592
-
A two-arm phase II study of temozolomide in patients with advanced gastrointestinal stromal tumors and other soft tissue sarcomas
-
Trent JC, Beach J, Burgess MA, et al. A two-arm phase II study of temozolomide in patients with advanced gastrointestinal stromal tumors and other soft tissue sarcomas. Cancer. 2003;98:2693-2699.
-
(2003)
Cancer
, vol.98
, pp. 2693-2699
-
-
Trent, J.C.1
Beach, J.2
Burgess, M.A.3
-
55
-
-
0033984319
-
Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival
-
DeMatteo RP, Lewis JJ, Leung D, et al. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg. 2000;231:51-58.
-
(2000)
Ann Surg
, vol.231
, pp. 51-58
-
-
DeMatteo, R.P.1
Lewis, J.J.2
Leung, D.3
-
56
-
-
0036570111
-
Tumor volume as a prognostic factor for sarcomatosis
-
Bilimoria MM, Holtz DJ, Mirza NQ, et al. Tumor volume as a prognostic factor for sarcomatosis. Cancer. 2002;94:2441-2446.
-
(2002)
Cancer
, vol.94
, pp. 2441-2446
-
-
Bilimoria, M.M.1
Holtz, D.J.2
Mirza, N.Q.3
-
57
-
-
0034794797
-
Results of hepatic resection for sarcoma metastatic to liver
-
DeMatteo RP, Shah A, Fong Y, et al. Results of hepatic resection for sarcoma metastatic to liver. Ann Surg. 2001;234:540-548.
-
(2001)
Ann Surg
, vol.234
, pp. 540-548
-
-
DeMatteo, R.P.1
Shah, A.2
Fong, Y.3
-
58
-
-
0026009657
-
Regression of hepatic metastases from gastrointestinal leiomyosarcoma after hepatic arterial chemoembolization
-
Mavligit GM, Zukiwski AA, Salem PA, et al. Regression of hepatic metastases from gastrointestinal leiomyosarcoma after hepatic arterial chemoembolization. Cancer. 1991;68:321-323.
-
(1991)
Cancer
, vol.68
, pp. 321-323
-
-
Mavligit, G.M.1
Zukiwski, A.A.2
Salem, P.A.3
-
59
-
-
0028958778
-
Gastrointestinal leiomyosarcoma metastatic to the liver. Durable tumor regression by hepatic chemoembolization infusion with cisplatin and vinblastine
-
Mavligit GM, Zukwiski AA, Ellis LM, et al. Gastrointestinal leiomyosarcoma metastatic to the liver. Durable tumor regression by hepatic chemoembolization infusion with cisplatin and vinblastine. Cancer. 1995;75:2083-2088.
-
(1995)
Cancer
, vol.75
, pp. 2083-2088
-
-
Mavligit, G.M.1
Zukwiski, A.A.2
Ellis, L.M.3
-
60
-
-
0032701962
-
Surgical resection and intraperitoneal chemotherapy for recurrent abdominal sarcomas
-
Eilber FC, Rosen G, Forscher C, et al. Surgical resection and intraperitoneal chemotherapy for recurrent abdominal sarcomas. Ann Surg Oncol. 1999;6:645-650.
-
(1999)
Ann Surg Oncol
, vol.6
, pp. 645-650
-
-
Eilber, F.C.1
Rosen, G.2
Forscher, C.3
-
61
-
-
0001035755
-
Adriamycin-based chemotherapy for leiomyosarcoma of the stomach and small intestine
-
Plager C, Papadoupolos NE, Salem P, et al. Adriamycin-based chemotherapy for leiomyosarcoma of the stomach and small intestine. Proc Annu Meet Am Soc Clin Oncol. 1991;10:352.
-
(1991)
Proc Annu Meet Am Soc Clin Oncol
, vol.10
, pp. 352
-
-
Plager, C.1
Papadoupolos, N.E.2
Salem, P.3
-
62
-
-
0001035756
-
Evaluation of ifosfamide in metastatic leiomyosarcomas of GI origin
-
Abstract 1252
-
Patel SR, Legha SS, Salem PA, et al. Evaluation of ifosfamide in metastatic leiomyosarcomas of GI origin. Proc Annu Meet Am Soc Clin Oncol. 1991;31:352. Abstract 1252.
-
(1991)
Proc Annu Meet Am Soc Clin Oncol
, vol.31
, pp. 352
-
-
Patel, S.R.1
Legha, S.S.2
Salem, P.A.3
-
63
-
-
0000084433
-
Contrast of response D-MAP plus sargramostin between patients with advanced malignant gastrointestinal stromal tumors and patients with other advanced leiomyosarcomas
-
Abstract 541
-
Edmonson J, Marks R, Buckner J, et al. Contrast of response D-MAP plus sargramostin between patients with advanced malignant gastrointestinal stromal tumors and patients with other advanced leiomyosarcomas. Proc Annu Meet Am Soc Clin Oncol. 1999;18. Abstract 541.
-
(1999)
Proc Annu Meet Am Soc Clin Oncol
, vol.18
-
-
Edmonson, J.1
Marks, R.2
Buckner, J.3
-
64
-
-
0033987746
-
Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
-
Druker BJ, Lydon NB. Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest. 2000;105:3-7.
-
(2000)
J Clin Invest
, vol.105
, pp. 3-7
-
-
Druker, B.J.1
Lydon, N.B.2
-
65
-
-
1342321786
-
Lessons learned from the development of imatinib
-
Lydon NB, Druker BJ. Lessons learned from the development of imatinib. Leuk Res. 2004;28:S29-38.
-
(2004)
Leuk Res
, vol.28
-
-
Lydon, N.B.1
Druker, B.J.2
-
66
-
-
0037186924
-
Imatinib mesylate - A new oral targeted therapy
-
Savage DG, Antman KH. Imatinib mesylate - a new oral targeted therapy. N Engl J Med. 2002;346:683-693.
-
(2002)
N Engl J Med
, vol.346
, pp. 683-693
-
-
Savage, D.G.1
Antman, K.H.2
-
67
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996;2:561-566.
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
68
-
-
0033816156
-
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
-
Buchdunger E, Cioffi CL, Law N, et al. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther. 2000;295:139-145.
-
(2000)
J Pharmacol Exp Ther
, vol.295
, pp. 139-145
-
-
Buchdunger, E.1
Cioffi, C.L.2
Law, N.3
-
69
-
-
12744269726
-
Inhibition of PDGF-R signaling by Gleevec (STI-571) in huma rhabdomyosarcoma cell lines
-
Trent JC, Hannay JA, Li L, et al. Inhibition of PDGF-R signaling by Gleevec (STI-571) in huma rhabdomyosarcoma cell lines. J Princess Takamatsu Symposia. 2001;32:16-29.
-
(2001)
J Princess Takamatsu Symposia
, vol.32
, pp. 16-29
-
-
Trent, J.C.1
Hannay, J.A.2
Li, L.3
-
70
-
-
0031454003
-
CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
-
Carroll M, Ohno-Jones S, Tamura S, et al. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood. 1997;90:4947-4952.
-
(1997)
Blood
, vol.90
, pp. 4947-4952
-
-
Carroll, M.1
Ohno-Jones, S.2
Tamura, S.3
-
71
-
-
0030031766
-
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
-
Buchdunger E, Zimmermann J, Mett H, et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 1996;56:100-104.
-
(1996)
Cancer Res
, vol.56
, pp. 100-104
-
-
Buchdunger, E.1
Zimmermann, J.2
Mett, H.3
-
72
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpez M, Resta DJ. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344:1031-1037.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpez, M.2
Resta, D.J.3
-
73
-
-
0242691170
-
Phase III dose-randomized study of imatinib mesylate (STI-571) for GIST: Intergroup S0033 early results
-
Abstract 3271
-
Benjamin RS, Rankin C, Fletcher C, et al. Phase III dose-randomized study of imatinib mesylate (STI-571) for GIST: Intergroup S0033 early results. Proc Annu Meet Am Soc Clin Oncol. 2003. Abstract 3271.
-
(2003)
Proc Annu Meet Am Soc Clin Oncol
-
-
Benjamin, R.S.1
Rankin, C.2
Fletcher, C.3
-
74
-
-
0000244046
-
Evaluation of the safety and efficacy of an oral molecularly-targeted therapy, STI571, in patients (pts) with unresectable or metastatic gastrointestinal stromal tumors (GISTs) expressing c-kit (CD117)
-
Abstract 1
-
Blanke CD, von Mehren M, Joensuu H, et al. Evaluation of the safety and efficacy of an oral molecularly-targeted therapy, STI571, in patients (pts) with unresectable or metastatic gastrointestinal stromal tumors (GISTs) expressing c-kit (CD117). Proc Annu Meet Am Soc Clin Oncol. 2001. Abstract 1.
-
(2001)
Proc Annu Meet Am Soc Clin Oncol
-
-
Blanke, C.D.1
Von Mehren, M.2
Joensuu, H.3
-
75
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002;347:472-480.
-
(2002)
N Engl J Med
, vol.347
, pp. 472-480
-
-
Demetri, G.D.1
Von Mehren, M.2
Blanke, C.D.3
-
76
-
-
0003222972
-
High incidence of durable responses induced by imatinib mesylate (Gleevec) in patients with unresectable and metastatic gastrointestinal stromal tumors (GISTs)
-
Abstract 1608
-
von Mehren M, Blanke C, Joensuu H, et al. High incidence of durable responses induced by imatinib mesylate (Gleevec) in patients with unresectable and metastatic gastrointestinal stromal tumors (GISTs). Proc Annu Meet Am Soc Clin Oncol. 2002. Abstract 1608.
-
(2002)
Proc Annu Meet Am Soc Clin Oncol
-
-
Von Mehren, M.1
Blanke, C.2
Joensuu, H.3
-
77
-
-
0002499759
-
STI57, an active drug in metastatic gastrointestinal stromal tumors (GIST), an EORTC phase I study
-
Abstract 2
-
Van Oosterom A, Judson I, Verweij J. STI57, an active drug in metastatic gastrointestinal stromal tumors (GIST), an EORTC phase I study. Proc Annu Meet Am Soc Clin Oncol. 2001. Abstract 2.
-
(2001)
Proc Annu Meet Am Soc Clin Oncol
-
-
Van Oosterom, A.1
Judson, I.2
Verweij, J.3
-
78
-
-
1642494654
-
Absolute bioavailability of imatinib (Glivec) orally versus intravenous infusion
-
Peng B, Dutreix C, Mehring G, et al. Absolute bioavailability of imatinib (Glivec) orally versus intravenous infusion. J Clin Pharmacol. 2004;44:158-162.
-
(2004)
J Clin Pharmacol
, vol.44
, pp. 158-162
-
-
Peng, B.1
Dutreix, C.2
Mehring, G.3
-
79
-
-
12144290456
-
Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588
-
Ie Coutre P, Kreuzer KA, Pursche S, et al. Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588. Cancer Chemother Pharmacol. 2004;53:313-323.
-
(2004)
Cancer Chemother Pharmacol
, vol.53
, pp. 313-323
-
-
Ie Coutre, P.1
Kreuzer, K.A.2
Pursche, S.3
-
80
-
-
0038009044
-
Imatinib mesylate in the treatment of chronic myeloid leukaemia
-
Druker BJ. Imatinib mesylate in the treatment of chronic myeloid leukaemia. Expert Opin Pharmacother. 2003;4:963-971.
-
(2003)
Expert Opin Pharmacother
, vol.4
, pp. 963-971
-
-
Druker, B.J.1
-
81
-
-
10744231436
-
Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia
-
O'Brien SG, Meinhardt P, Bond E, et al. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. Br J Cancer. 2003;89:1855-1859.
-
(2003)
Br J Cancer
, vol.89
, pp. 1855-1859
-
-
O'Brien, S.G.1
Meinhardt, P.2
Bond, E.3
-
82
-
-
4744338886
-
Effect of St John's wort on imatinib mesylate pharmacokinetics
-
Frye RF, Fitzgerald SM, Lagattuta TF, et al. Effect of St John's wort on imatinib mesylate pharmacokinetics. Clin Pharmacol Ther. 2004;76:323-329.
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 323-329
-
-
Frye, R.F.1
Fitzgerald, S.M.2
Lagattuta, T.F.3
-
83
-
-
0242361680
-
Determination of drug synergism between the tyrosine kinase inhibitors NSC 680410 (adaphostin) and/or STI571 (imatinib mesylate, Gleevec) with cytotoxic drugs against human leukemia cell lines
-
Epub 2003 Jun 25
-
Avramis IA, Laug WE, Sausville EA, et al. Determination of drug synergism between the tyrosine kinase inhibitors NSC 680410 (adaphostin) and/or STI571 (imatinib mesylate, Gleevec) with cytotoxic drugs against human leukemia cell lines. Cancer Chemother Pharmacol. 2003;52:307-318. Epub 2003 Jun 25.
-
(2003)
Cancer Chemother Pharmacol
, vol.52
, pp. 307-318
-
-
Avramis, I.A.1
Laug, W.E.2
Sausville, E.A.3
-
84
-
-
0035810148
-
Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor
-
Joensuu H, Roberts PJ, Sartomo-Rikala M, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med. 2001;344:1052-1056.
-
(2001)
N Engl J Med
, vol.344
, pp. 1052-1056
-
-
Joensuu, H.1
Roberts, P.J.2
Sartomo-Rikala, M.3
-
85
-
-
0035960428
-
Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase I study
-
van Oosterom AT, Judson I, Verweij J, et al. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet 2001;358:1421-1423.
-
(2001)
Lancet
, vol.358
, pp. 1421-1423
-
-
Van Oosterom, A.T.1
Judson, I.2
Verweij, J.3
-
86
-
-
12744281280
-
Early efficacy comparison of two doses of imatinib for the treatment of advanced gastrointestinal stromal tumors (GIST): Interim results of a randomized phase III trial from the EORTC-STBSG, ISG, and AGITG
-
Abstract 3272
-
Verweij J, Casali J, Zalcberg A, et al. Early efficacy comparison of two doses of imatinib for the treatment of advanced gastrointestinal stromal tumors (GIST): interim results of a randomized phase III trial from the EORTC-STBSG, ISG, and AGITG. Proc Annu Meet Am Soc Clin Oncol. 2003. Abstract 3272.
-
(2003)
Proc Annu Meet Am Soc Clin Oncol
-
-
Verweij, J.1
Casali, J.2
Zalcberg, A.3
-
87
-
-
4544227216
-
Dose effect of imatinib (IM) in patients (pts) with metastatic GIST - A phase III sarcoma group study S0033
-
Abstract 9005
-
Rankin C, von Mehren M, Blanke C, et al. Dose effect of imatinib (IM) in patients (pts) with metastatic GIST - a phase III sarcoma group study S0033. Proc Annu Meet Am Soc Clin Oncol. 2004. Abstract 9005.
-
(2004)
Proc Annu Meet Am Soc Clin Oncol
-
-
Rankin, C.1
Von Mehren, M.2
Blanke, C.3
-
88
-
-
20844433223
-
Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial
-
Verweij J, Casali PG, Zalcberg J, et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet 2004;364:1127-1134.
-
(2004)
Lancet
, vol.364
, pp. 1127-1134
-
-
Verweij, J.1
Casali, P.G.2
Zalcberg, J.3
-
89
-
-
0005828537
-
Imatinib (Glivec) 400 vs 800 mg daily in patients with gastrointestinal stromal tumors (GIST): A randomized phase III trial from the EORTC Soft Tissue and Bone Sarcoma Group, the Italian Sarcoma Group (ISG) and the Australasian Gastrointestinal Trials Group (AGITG). A toxicity report
-
Abstract 1650
-
Casali PG, Verweij J, Zalcberg A, et al. Imatinib (Glivec) 400 vs 800 mg daily in patients with gastrointestinal stromal tumors (GIST): a randomized phase III trial from the EORTC Soft Tissue and Bone Sarcoma Group, the Italian Sarcoma Group (ISG) and the Australasian Gastrointestinal Trials Group (AGITG). A toxicity report. Proc Annu Meet Am Soc Clin Oncol. 2002. Abstract 1650.
-
(2002)
Proc Annu Meet Am Soc Clin Oncol
-
-
Casali, P.G.1
Verweij, J.2
Zalcberg, A.3
-
90
-
-
12744254051
-
-
Trent J. A Prospective, Randomized, Phase II Study of Preoperative Plus Postoperative Imatinib Mesylate (Gleevec, Formerly STI-571) in Patients With Primary, Recurrent, or Metastatic Resectable, Kit-Expressing, Gastrointestinal Stromal Tumor (GIST). Available at http://utmext01a.mdacc.tmc.edu/dept/prot/ clinicaltrialswp.nsf/Index/ID03-0023. Accessed December 8, 2004.
-
A Prospective, Randomized, Phase II Study of Preoperative Plus Postoperative Imatinib Mesylate (Gleevec, Formerly STI-571) in Patients with Primary, Recurrent, or Metastatic Resectable, Kit-Expressing, Gastrointestinal Stromal Tumor (GIST)
-
-
Trent, J.1
-
92
-
-
0037339961
-
Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: Early assessment predicts clinical response
-
Davis DW, Buchholz TA, Hess KR, et al. Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: early assessment predicts clinical response. Clin Cancer Res. 2003;9:955-960.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 955-960
-
-
Davis, D.W.1
Buchholz, T.A.2
Hess, K.R.3
-
95
-
-
0142121411
-
Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study
-
Verweij J, van Oosterom A, Blay JY, et al. Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study. Eur J Cancer. 2003;39:2006-2011.
-
(2003)
Eur J Cancer
, vol.39
, pp. 2006-2011
-
-
Verweij, J.1
Van Oosterom, A.2
Blay, J.Y.3
|