Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-β following ocular HSV-1 infection

Experimental Eye Research

Volumn 80, Issue 2, 2005, Pages 167-173

  Al Khatib, Khaldun ^a   Williams, Bryan R G ^b   Silverman, Robert H ^b   Halford, William ^c   Carr, Daniel J J ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

adenoviral vector; HSV 1; IFN ; keratitis; OAS; PKR

Indexed keywords

ADENOVIRUS VECTOR; BETA INTERFERON; IMMEDIATE EARLY PROTEIN; OLIGOADENYLATE SYNTHETASE; PROTEIN KINASE; RIBONUCLEASE L; SYNTHETASE; THYMIDINE KINASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GENETIC TRANSDUCTION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; INFECTION PREVENTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE; TRANSGENE; TRIGEMINUS GANGLION; VIRUS GENE; VIRUS REPLICATION; WILD TYPE;

ADENOVIRIDAE; ANIMALS; EIF-2 KINASE; ENDORIBONUCLEASES; FEASIBILITY STUDIES; FEMALE; GENE THERAPY; GENETIC VECTORS; HERPESVIRUS 1, HUMAN; INTERFERON-BETA; KERATITIS, HERPETIC; MICE; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL ANALYSIS; TRANSDUCTION, GENETIC;

EID: 12744267757     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2004.08.026     Document Type: Article

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