Peripheral blood CD4 + and CD8 + t cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects

Clinical and Experimental Allergy

Volumn 32, Issue 3, 2002, Pages 427-433

  Cho, S H ^c   Stanciu, L A ^a   Begishivili, T ^a   Bates, P J ^a   Holgate, S T ^a   Johnston, S L ^b  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c Seoul National University   (South Korea)

Author keywords

Asthma; Atopy; Flow cytometry; Human; T lymphocytes; Th1 Th2

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5;

ADULT; AIRWAY; ALLERGIC ASTHMA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; HUMAN; IMMUNOHISTOCHEMISTRY; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ADULT; ASTHMA; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; FORCED EXPIRATORY VOLUME; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; PREDICTIVE VALUE OF TESTS; REFERENCE VALUES; SEVERITY OF ILLNESS INDEX; STAINING AND LABELING; STATISTICS; T-LYMPHOCYTE SUBSETS;

EID: 0036224256     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2002.01281.x     Document Type: Article

References (44)

1. 2-like bronchoalveolar T-lymphocyte population in atopic asthma
2. Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with asthma
3. Increased interferon-γ and tumor necrosis factor-α in bronchoalveolar lavage (BAL) fluid after antigen challenge in allergic subjects
4. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma
5. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders
6. + T-cell clones derived from a patient with severe atopic disease
7. Interleukin-4-5-6 and TNF-alpha in normal and asthmatic airways: Evidence for the human mast cells as an important source of these cytokines
8. Human peripheral blood basophils primed by interleukin 3 produce interleukin 4 in response to immunoglobulin E receptor stimulation
9. Uncoupling of cytokine mRNA expression and protein secretion during the induction phase of T cell anergy
10. + lymphocytes
11. + T cells in atopic asthma
12. Generation of polarized antigen-specific CD8 effector populations: Reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles
13. Detection of intracellular cytokines by flow cytometry
14. +CD27-lymphocyte subpopulation
15. Flowcytometric determination of cytokines in activated murine helper lymphocytes: Expression of interleukin-10 and interferon-γ and interleukin-4 producing cells
16. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry
17. Identification of functional subsets by flow cytometry: Intracellular detection of cytokine expression
18. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma
19. Standardization of bronchial inhalation challenge procedures
20. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of Th1 and Th2 clones
21. IgE production by normal human lymphocytes is induced by interleukin-4 and suppressed by interferons-α and -γ and prostaglandin E2
22. Decreased frequency of interferon-γ- and interleukin-2-producing cells in patients with atopic diseases measured at the single cell level
23. CD4 T-lymphocyte activation in acute severe asthma
24. Elevated serum interferon-γ in atopic asthma correlates with increased airway responsiveness and circardian peak expiratory flow variation
25. Effects of IFN on human eosinophils in comparison with other cytokines: A novel class of eosinophil activators with delayed onset of action
26. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon
27. Selective induction of intercellular adhesion molecule-1 by interferon-γ in human airway epithelial cells
28. Treatment of steroid-dependent asthma with recombinant interferon-gamma
29. Frequencies of T cells expressing interleukin-4 and interleukin-5 in atopic asthmatic children. Comparison with atopic asthmatic adults
30. Transgenic mice expressing a B cell growth and difl'erentiation factor gene (interleukin-5) develop eosinophilia and autoantibody production
31. Interleukin-4 and its receptor: Essential mediators of the allergic response
32. Polymerase chain reaction quantification of cytokine messenger RNA expression in peripheral blood cells of patients with acute exacerbations of asthma: Effect of glucocorticoid therapy
33. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells
34. IL-13 selectively induces vascular cell adhesion molecule-1 expression on human endothelial cells
35. IL-13 expression at the sites of allergen challenge in patients with asthma
36. Updates on cells and cytokine. IL-10: Evolving concepts
37. Interleukin-10 regulation in normal and asthmatic subjects
38. Increased interleukin-10 mRNA expression in atopic allergy and asthma
39. + T cells in asthma
40. Peripheral blood CD4 but not CD8 T-lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: Effect of glucocorticoid therapy
41. + T cell frequencies by flow cytometry. Evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency
42. Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry
43. Frequency and characterization of antigen-specific IL-4- and IL-13-producing basophils and T cells in peripheral blood of healthy and asthmatic subjects