The dual effects of nitric oxide synthase inhibitors on ischemia-reperfusion injury in rat hearts

Basic Research in Cardiology

Volumn 98, Issue 5, 2003, Pages 319-328

  Kobara, Miyuki ^a   Tatsumi, Tetsuya ^a   Takeda, Mitsuo ^a   Mano, Akiko ^a   Yamanaka, Satoshi ^a   Shiraishi, Jun ^a   Keira, Natsuya ^a   Matoba, Satoaki ^a   Asayama, Jun ^b   Nakagawa, Masao ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Energy metabolism; Ischemia reperfusion injury; L NMMA; Nitric oxide; Oxidative stress

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE TRIPHOSPHATE; ARGININE; CREATINE KINASE; GLYCOGEN; LACTIC ACID; MALONALDEHYDE; N(G) METHYL DEXTRO ARGININE; N(G) METHYLARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHATE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG EFFECT; DRUG MEGADOSE; ENERGY METABOLISM; ENZYME INHIBITION; ENZYME RELEASE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PERFUSION; LOW DRUG DOSE; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY;

ADENINE NUCLEOTIDES; ANIMALS; CREATINE; CREATINE KINASE; ENZYME INHIBITORS; GLUCOSE; GLYCOGEN; HEART; LACTIC ACID; MALONDIALDEHYDE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RESEARCH DESIGN; VENTRICULAR FUNCTION, LEFT;

EID: 12444289468     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-003-0423-x     Document Type: Article

References (41)

1. Kelly RA, Balligand JL, Smith TW (1996) Nitric oxide and cardiac function. Circ Res 79: 363-380
2. Palmer RM, Rees DD, Ashton DS, Moncada S (1988) L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun 153: 1251-1256
3. Palmer RM, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524-526
4. Moncada S, Palmer RM, Higgs EA (1991) Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142
5. Moncada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329: 2002-2012
6. Ferdinandy P, Danial H, Ambrus I, Rothery RA, Schultz R (2000) Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure. Circ Res 87: 241-247
7. Tatsumi T, Matoba S, Kawahara A, Keira N, Shiraishi J, Akashi K, Kobara M, Tanaka T, Katamura M, Nakagawa C, Ohta B, Shirayama T, Takeda K, Asayama J, Fliss H, Nakagawa M (2000) Cytokine-induced nitric oxide production inhibits mitochondrial energy production and impairs contractile function in rat cardiac myocytes. J Am Coll Cardiol 35: 1338-1346
8. Evans T, Carpenter A, Kinderman H, Cohen J (1993) Evidence of increased nitric oxide production in patients with the sepsis syndrome. Circ Shoch 41: 77-81
9. Bolli R (2001) Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: An overview of a decade of research. J Mol Cell Cardiol 33: 1897-918
10. Hoshida S, Yamashita N, Igarashi J, Nishida M, Hori M, Kamada T, Kuzuya T, Tada M (1995) Nitric oxide synthase protects the heart against ischemia-reperfusion injury in rabbits. J Pharmacol Exp Ther 274: 413-418
11. Node K, Kitakaze M, Kosaka H, Komamura K, Minamino T, Inoue M, Tada M, Hori M, Kamada T (1996) Increased release of NO during ischemia reduces myocardial contractility and improves metabolic dysfunction. Circulation 93: 356-364
12. Pabla R, Buda AJ, Flynn DM, Blesse SA, Shin AM, Curtis MJ, Lefer DJ (1996) Nitric oxide attenuates neutrophil-mediated myocardial contractile dysfunction after ischemia and reperfusion. Circ Res 78: 65-72
13. Kitakaze M, Node K, Minamino T, Kosaka H, Shinozaki Y, Mori H, Inoue M, Hori M, Kamada T (1996) Role of nitric oxide in regulation of coronary blood flow during myocardial ischemia in dogs. J Am Coll Cardiol 27: 1804-1812
14. Weyrich AS, Ma XL, Lefer AM (1992) The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat. Circulation 86: 279-288
15. Pabla R, Curtis MJ (1996) Effect of endogenous nitric oxide on cardiac systolic and diastolic function during ischemia and reperfusion in the rat isolated perfused heart. J Mol Cell Cardiol 28: 2111-2121
16. Heusch G, Post H, Michel MC, Kelm M, Schulz R (2000) Endogenous nitric oxide and myocardial adaptation to ischemia. Circ Res 87: 146-152
17. Depre C, Vanoverschelde JL, Goudemant JF, Mottet I, Hue L (1995) Protection against ischemic injury by nonvasoactive concentrations of nitric oxide synthase inhibitors in the perfused rabbit heart. Circulation 92: 1911-1918
18. Schulz R, Wambolt R (1995) Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischemia-reperfusion injury. Cardiovasc Res 30: 432-439
19. Patel VC, Yellon DM, Singh KJ, Neild GH, Woolfson RG (1993) Inhibition of nitric oxide limits infarct size in the in situ rabbit heart. Biochem Biophys Res Commun 194: 234-238
20. Zweier JL, Kuppusamy P, Williams R, Rayburn BK, Smith D, Weisfeldt ML, Flaherty JT (1989) Measurement and characterization of postischemic free radical generation in the isolated perfused heart. J Biol Chem 264: 18890-18895
21. Yasmin W, Strynadka KD, Schulz R (1997) Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts. Cardiovasc Res 33: 422-432
22. G-monomethyl L-Arginine inhibits endothelium-derived relaxing factor-stimulated cyclic GMP accumulation in cocultures of endothelial and vascular smooth muscle cells by action specific to the endothelial cell. Circ Res 67: 979-985
23. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL (1992) Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 257: 387-389
24. Rees DD, Palmer RM, Hodson HF, Moncada S (1989) A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol 96: 418-424
25. Kobara M, Tatsumi T, Matoba S, Yamahara Y, Nakagawa C, Ohta B, Matsumoto T, Inoue D, Asayama J, Nakagawa M (1996) Effect of ischemic preconditioning on mitochondrial oxidative phosphorylation and high energy phosphate in rat hearts. J Mol Cell Cardiol 28: 417-428
26. Rosalki SB (1967) An improved procedure for serum creatine phosphokinase determination. J Lab Clin Med 69: 696-705
27. Asayama J, Yamahara Y, Ohta B, Miyazaki H, Tatsumi T, Matsumoto T, Inoue D, Nakagawa M (1992) Release kinetics of cardiac troponin T in coronary effluent from isolated rat hearts during hypoxia and reoxygenation. Basic Res Cardiol 87: 428-436
28. Brodal BP, Gehrken BB (1986) Enzymatic microanalysis of glycogen. Scand J Clin Lab Invest 46: 193-195
29. Ohishi N, Ohkawa H, Miike A, Tatano T, Yagi K (1985) A new assay method for lipid peroxides using a methylene blue derivative. Biochem Int 10: 205-211
30. Clarke K, O'Connor AJ, Willis RJ (1987) Temporal relation between energy metabolism and myocardial function during ischemia and reperfusion. Am J Physiol 253: H412-H421
31. Mela-Riker LM, Bukoski RD (1985) Regulation of mitochondrial activity in cardiac cells. Annu Rev Physiol 47: 645-663
32. Csonka C, Szilvassy Z, Fulop F, Pali T, Blasig IE, Tosaki A, Schulz R, Ferdinandy P (1999) Classic preconditioning decreases the harmful accumulation of nitric oxide during ischemia and reperfusion in rat hearts. Circulation 100: 2260-2266
33. Liu P, Hock CE, Nagele R, Wong PY (1997) Formation of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury in rats. Am J Physiol 272: H2327-H2336
34. Susan L, Gorman T, Zweier JL (1990) Evaluation of the role of xanthine oxidase in myocardial reperfusion injury. J Biol Chem 265: 6656-6663
35. Wang P, Zweier JL (1996) Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury. J Biol Chem 271: 29223-29230
36. Baker CS, Dutka DP, Pagano D, Rimoldi O, Pitt M, Hall RJ, Polak JM, Bonser RS, Camici PG (2002) Immunocytochemical evidence for inducible nitric oxide synthase and cyclooxygenase-2 expression with nitrotyrosine formation in human hibernating myocardium. Basic Res Cardiol 97: 409-415
37. Radi R, Bechman JS, Bush KM, Freeman BA (1991) Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys 288: 481-487
38. Radi R, Rodriguez M, Castro L, Telleri R (1994) Inhibition of mitochondrial electron transport by peroxynitrite. Arch Biochem Biophy 308: 89-95
39. Ishida H, Ichimori K, Hirota Y, Fukahori M, Nakazawa H (1996) Peroxynitrite-induced cardiac myocyte injury. Free Radic Biol Med 20: 343-350
40. 2 in quiescent isolated rat cardiomyocytes. Basic Res Cardiol 96: 623-629
41. Beresewicz A, Karwatowska-Prokopczuk E, Lewartowski B, Cedro-Ceremuzynska K (1995) A protective role of nitric oxide in isolated ischemia/reperfused rat heart. Cardiovasc Res 30: 1001-1008