Immunocytochemical evidence for inducible nitric oxide synthase and cyclooxygenase-2 expression with nitrotyrosine formation in human hibernating myocardium

Basic Research in Cardiology

Volumn 97, Issue 5, 2002, Pages 409-415

  Baker, Christopher S R ^a   Dutka, David P ^a   Pagano, Domenico ^c   Rimoldi, Ornella ^a   Pitt, Michael ^c   Hall, Roger J C ^a   Polak, Julia M ^b   Bonser, Robert S ^c   Camici, Paolo G ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^c QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

Coronary artery disease; Free radicals; Histochemistry; Positron emission tomography; Ventricular dysfunction

Indexed keywords

3 NITROTYROSINE; ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FLUORODEOXYGLUCOSE F 18; FREE RADICAL; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDIZING AGENT; PEROXYNITRITE; SUPEROXIDE;

ADULT; AGED; ARTICLE; BLOOD VESSEL REACTIVITY; CADAVER; CLINICAL ARTICLE; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; DONOR; HEART FAILURE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE WALL MOTION; HEART MUSCLE BIOPSY; HEART MUSCLE CELL; HEART MUSCLE REPERFUSION; HEART MUSCLE REVASCULARIZATION; HEART TRANSPLANTATION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MYOCARDIAL HIBERNATION; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; SURVIVAL; TRANSIENT ISCHEMIC ATTACK;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BIOPSY; CORONARY DISEASE; CYCLOOXYGENASE 2; DIURETICS; ECHOCARDIOGRAPHY; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MEMBRANE PROTEINS; MIDDLE AGED; MYOCARDIAL STUNNING; MYOCARDIUM; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; TYROSINE;

EID: 0036736045     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950200050     Document Type: Article

References (45)

1. Stress echocardiography: Recommendations for performance and interpretation of stress echocardiography. Stress Echocardiography Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography
2. Repetitive myocardial stunning in pigs is associated with an increased formation of reactive nitrogen species
3. Repetitive myocardial stunning in pigs is associated with the increased expression of inducible and constitutive nitric oxide synthases
4. Mechanisms of myocardial stunning
5. The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning
6. Inhibition of nuclear factor kappa B attenuates pro-inflammatory cytokine and inducible nitric-oxide synthase expression in post-ischemic myocardium
7. Myocardial calcium-independent nitric oxide synthase activity is present in dilated cardiomyopathy, myocarditis, and post-partum cardiomyopathy but not in ischaemic or valvar heart disease
8. Monophosphoryl lipid A induces delayed preconditioning against cardiac ischemia-reperfusion injury
9. Hibernating myocardium: An incomplete adaptation to ischemia
10. Prostaglandin E1 attenuates postischemic contractile dysfunction after brief coronary occlusion and reperfusion
11. Beneficial effects of iloprost in the stunned canine myocardium
12. Efficacy of coronary angioplasty for the treatment of hibernating myocardium
13. Heterogeneous expression and activity of endothelial and inducible nitric oxide synthases in end-stage human heart failure
14. The early stages of absorption of injected horseradish in the proximal tubules of mouse kidney: Ultrastructure cytochemistry by a new technique
15. Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy
16. Expression of inducible nitric oxide synthase in human heart failure
17. Hibernating myocardium
18. Endogenous nitric oxide and myocardial adaptation to ischemia
19. Reduction by prostaglandin E1 or prostaglandin E0 of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels
20. Ischemic preconditioning (PC) upregulates expression of iNOS mRNA in conscious rabbits via an NO dependent mechanism
21. Nitric oxide and cardiac function
22. Cytokines and cardiac contractile function
23. Cellular mechanisms of myocardial stunning
24. Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis
25. Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats
26. Pathophysiology of chronic left ventricular dysfunction
27. Cyclooxygenase-2: Regulation and relevance in inflammation
28. Peroxynitrite: A two-faced metabolite of nitric oxide
29. Prostanoid receptors: Structures, properties, and functions
30. Coronary artery bypass surgery as treatment for ischemic heart failure: The predictive value of viability assessment with quantitative positron emission tomography for symptomatic and functional outcome
31. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide
32. Interactions of nitric oxide with cyclooxygenase: In vitro, ex vivo and in vivo studies
33. Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency
34. Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits
35. The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system
36. Iloprost inhibits neutrophil function in vitro and in vivo and limits experimental infarct size in canine heart
37. Infarct salvage with liposomal prostaglandin E1 administered by intravenous bolus immediately before reperfusion in a canine infarction-reperfusion model
38. Co-induction of nitric oxide synthase and cyclooxygenase: Interactions between nitric oxide and prostanoids
39. Hibernating myocardium
40. Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure
41. Cyclooxygenase-2 induction in congestive cardiac failure, friend or foe?
42. Inhibition of rat cardiac muscle contraction and mitochondrial respiration by endogenous peroxynitrite formation during posthypoxic reoxygenation
43. Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts
44. Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial polysaccharide
45. Tyrosine nitration as a mechanism of selective inactivation of prostacycline synthase by peroxynitrite