Depletion of deoxyribonucleoside triphosphate pools in tumor cells by nitric oxide

Free Radical Biology and Medicine

Volumn 36, Issue 4, 2004, Pages 507-516

  Roy, Beatrice ^a   Guittet, Olivier ^a   Beuneu, Claire ^a   Lemaire, Genevieve ^a   Lepoivre, Michel ^a  

^a CNRS   (France)

Author keywords

Deoxyribonucleotide; Free radicals; Leukemia; Macrophage; Nitric oxide; Ribonucleotide reductase

Indexed keywords

CYCLIC GMP; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; DIPYRIDAMOLE; HYDROXYUREA; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PYRIMIDINE NUCLEOSIDE; SCAVENGER; THYMIDINE TRIPHOSPHATE;

ANIMAL CELL; ARTICLE; COCULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TUMOR CELL;

LETHRINIDAE;

EID: 1242328665     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2003.11.028     Document Type: Article

References (46)

1. Reichard P. Ribonucleotide reductases: the evolution of allosteric regulation. Arch. Biochem. Biophys. 397:2002;149-155.
2. Bianchi V., Pontis E., Reichard P. Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis. J. Biol. Chem. 261:1986;16037-16042.
3. Yarbro J.W. Mechanism of action of hydroxyurea. Semin. Oncol. 19:1992;1-10.
4. Plunkett W., Huang P., Xu Y.Z., Heinemann V., Grunewald R., Gandhi V. Gemcitabine: metabolism, mechanisms of action, and self-potentiation. Semin. Oncol. 22:1995;3-10.
5. Lepoivre M., Fieschi F., Coves J., Thelander L., Fontecave M. Inactivation of ribonucleotide reductase by nitric oxide. Biochem. Biophys. Res. Commun. 179:1991;442-448.
6. Kwon N.S., Stuehr D.J., Nathan C.F. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J. Exp. Med. 174:1991;761-767.
7. Lepoivre M., Flaman J.-M., Henry Y. Early loss of the tyrosyl radical in ribonucleotide reductase of adenocarcinoma cells producing nitric oxide. J. Biol. Chem. 267:1992;22994-23000.
8. Roy B., Lepoivre M., Henry Y., Fontecave M. Inhibition of ribonucleotide reductase by nitric oxide derived from thionitrites: reversible modifications of both subunits. Biochemistry. 34:1995;5411-5418.
9. Guittet O., Ducastel B., Salem J.S., Henry Y., Rubin H., Lemaire G., Lepoivre M. Differential sensitivity of the tyrosyl radical of mouse ribonucleotide reductase to nitric oxide and peroxynitrite. J. Biol. Chem. 273:1998;22136-22144.
10. Lemaire G., Alvarez-Pachon F.J., Beuneu C., Lepoivre M., Petit J.F. Differential cytostatic effects of NO donors and NO producing cells. Free Radic. Biol. Med. 26:1999;1274-1283.
11. Burney S., Tamir S., Gal A., Tannenbaum S.R. A mechanistic analysis of nitric oxide-induced cellular toxicity. Nitric Oxide. 1:1997;130-144.
12. Poluha W., Schonhoff C.M., Harrington K.S., Lachyankar M.B., Crosbie N.E., Bulseco D.A., Ross A.H. A novel, nerve growth factor-activated pathway involving nitric oxide, p53, and p21(WAF1) regulates neuronal differentiation of PC12 cells. J. Biol. Chem. 272:1997;24002-24007.
13. Pervin S., Singh R., Chaudhuri G. Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1. Proc. Natl. Acad. Sci. USA. 98:2001;3583-3588.
14. Moochhala S., Rajnakova A. Role of nitric oxide in cancer biology. Free Radical Res. 31:1999;671-679.
15. Xie K.P., Fidler I.J. Therapy of cancer metastasis by activation of the inducible nitric oxide synthase. Cancer Metastasis Rev. 17:1998;55-75.
16. Burney S., Caulfield J.L., Niles J.C., Wishnok J.S., Tannenbaum S.R. The chemistry of DNA damage from nitric oxide and peroxynitrite. Mutat. Res. 424:1999;37-49.
17. Lepoivre M., Flaman J.M., Bobe P., Lemaire G., Henry Y. Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide - relationship to cytostasis induced in tumor cells by cytotoxic macrophages. J. Biol. Chem. 269:1994;21891-21897.
18. Schmidt K., WernerFelmayer G., Mayer B., Werner E.R. Preferential inhibition of inducible nitric oxide synthase in intact cells by the 4-amino analogue of tetrahydrobiopterin. Eur. J. Biochem. 259:1999;25-31.
19. Roy B., Beuneu C., Roux P., Buc H., Lemaire G., Lepoivre M. Simultaneous determination of pyrimidine or purine deoxyribonucleoside triphosphates using a polymerase assay. Anal. Biochem. 269:1999;403-409.
20. Gao W.Y., Zhou B.S., Johns D.G., Mitsuya H., Yen Y. Role of the M2 subunit of ribonucleotide reductase in regulation by hydroxyurea of the activity of the anti-HIV-1 agent 2′,3′-dideoxyinosine. Biochem. Pharmacol. 56:1998;105-112.
21. Oliver F.J., Collins M.K.L., Lopez-Rivas A. dNTP pools imbalance as a signal to initiate apoptosis. Experientia. 52:1996;995-1000.
22. Grusch M., Fritzer-Szekeres M., Fuhrmann G., Rosenberger G., Luxbacher C., Elford H.L., Smid K., Peters G.J., Szekeres T., Krupitza G. Activation of caspases and induction of apoptosis by novel ribonucleotide reductase inhibitors amidox and didox. Exp. Hematol. 29:2001;623-632.
23. Brune B., vonKnethen A., Sandau K.B. Nitric oxide and its role in apoptosis. Eur. J. Pharmacol. 351:1998;261-272.
24. Eu J.P., Liu L.M., Zeng M., Stamler J.S. An apoptotic model for nitrosative stress. Biochemistry. 39:2000;1040-1047.
25. Stadecker M.J., Calderon J., Karnovsky M.L., Unanue E.R. Synthesis and release of thymidine by macrophages. J. Immunol. 119:1977;1738-1743.
26. Martomo S.A., Mathews C.K. Effects of biological DNA precursor pool asymmetry upon accuracy of DNA replication in vitro. Mutat. Res. 499:2002;197-211.
27. Elford H.L., Freese M., Passamani E., Morris H.P. Ribonucleotide reductase and cell proliferation. I. Variations of ribonucleotide reductase activity with tumor growth rate in a series of rat hepatomas. J. Biol. Chem. 245:1970;5228-5233.
28. Weber G. Biochemical strategy of cancer cells and the design of chemotherapy. Cancer Res. 43:1983;3466-3492.
29. Jensen R.A., Page D.L., Holt J.T. Identification of genes expressed in premalignant breast disease by microscopy-directed cloning. Proc. Natl. Acad. Sci. USA. 91:1994;9257-9261.
30. Fan H.Z., Villegas C., Huang A., Wright J.A. The mammalian ribonucleotide reductase R2 component cooperates with a variety of oncogenes in mechanisms of cellular transformation. Cancer Res. 58:1998;1650-1653.
31. Nussler A.K., Di Silvio M., Billiar T.R., Hoffman R.A., Geller D.A., Selby R., Madariaga J., Simmons R.L. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J. Exp. Med. 176:1992;261-264.
32. Guo F.H., Deraeve H.R., Rice T.W., Stuehr D.J., Thunnissen F.B.J.M., Erzurum S.C. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc. Natl. Acad. Sci. USA. 92:1995;7809-7813.
33. Hickman-Davis J.M., O'Reilly P., Davis I.C., Peti-Peterdi J., Davis G., Young K.R., Devlin R.B., Matalon S. Killing of Klebsiella pneumoniae by human alveolar macrophages. Am. J. Physiol. 282:2002;L944-L956.
34. Reveneau S., Arnould L., Jolimoy G., Hilpert S., Lejeune P., SaintGiorgio V., Belichard C., Jeannin J.F. Nitric oxide synthase in human breast cancer is associated with tumor grade, proliferation rate, and expression of progesterone receptors. Lab. Invest. 79:1999;1215-1225.
35. Thomsen L.L., Miles D.W., Happerfield L., Bobrow L.G., Knowles R.G., Moncada S. Nitric oxide synthase activity in human breast cancer. Br. J. Cancer. 72:1995;41-44.
36. Jansson O.T., Morcos E., Brundin L., Bergerheim U.S.R., Adolfsson J., Wiklund N.P. Nitric oxide synthase activity in human renal cell carcinoma. J. Urol. 160:1998;556-560.
37. Koh E., Noh S.H., Lee Y.D., Lee H.Y., Han J.W., Lee H.W., Hong S. Differential expression of nitric oxide synthase in human stomach cancer. Cancer Lett. 146:1999;173-180.
38. Onier N., Hilpert S., Reveneau S., Arnould L., SaintGiorgio V., Exbrayat J.M., Jeannin J.E. Expression of inducible nitric oxide synthase in tumors in relation with their regression induced by lipid A in rats. Int. J. Cancer. 81:1999;755-760.
39. Hajri A., Metzger E., Vallat F., Coffy S., Flatter E., Evrard S., Marescaux J., Aprahamian M. Role of nitric oxide in pancreatic tumour growth: in vivo and in vitro studies. Br. J. Cancer. 78:1998;841-849.
40. Nandy P., Lien E.J., Avramis V.I. Inhibition of ribonucleotide reductase by a new class of isoindole derivatives: drug synergism with cytarabine (Ara-C) and induction of cellular apoptosis. Anticancer Res. 19:1999;1625-1633.
41. Anand S., Verma H., Kumar L., Singh N. Induction of apoptosis in chronic myelogenous leukemia lymphocytes by hydroxyurea and adriamycin. Cancer Lett. 88:1995;101-105.
42. Tanaka H., Arakawa H., Yamaguchi T., Shiraishi K., Fukuda S., Matsui K., Takei Y., Nakamura Y. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature. 404:2000;42-49.
43. Yamaguchi T., Matsuda K., Sagiya Y., Iwadate M., Fujino M.A., Nakamura Y., Arakawa H. p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint. Cancer Res. 61:2001;8256-8262.
44. Guittet O., Hakansson P., Voevodskaya N., Fridd S., Graslund A., Arakawa H., Nakamura Y., Thelander L. Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. J. Biol. Chem. 276:2001;40647-40651.
45. Kimura T., Takeda S., Sagiya Y., Gotoh M., Nakamura Y., Arakawa H. Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Nat. Genet. 34:2003;440-445.
46. Zhao X., Muller E.G., Rothstein R. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell. 2:1998;329-340.