DNTP pools imbalance as a signal to initiate apoptosis

Experientia

Volumn 52, Issue 10-11, 1996, Pages 995-1000

  Oliver, F J ^a   Collins, M K L ^b   Lopez Rivas A ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Apoptosis; blc 2; dNTP metabolism; Hemopoietic cells; Interleukin 3; Thymidine kinase

Indexed keywords

DNA FRAGMENT; INTERLEUKIN 3; PARATHION; THYMIDINE KINASE;

ANIMAL CELL; APOPTOSIS; BIOSYNTHESIS; CONTROLLED STUDY; DNA SYNTHESIS; HEMATOPOIETIC CELL; MOUSE; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL DEATH; CELLS, CULTURED; DEOXYRIBONUCLEOTIDES; DNA; DNA REPAIR; INTERLEUKIN-3; MICE; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS, EXPERIMENTAL;

ANIMALIA; MURINAE;

EID: 0029987410     PISSN: 00144754     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01920108     Document Type: Review

References (40)

1. Liebermann D. A., Hoffman B. and Steinman R. A. (1995) Molecular control or growth arrest and apoptosis: p53-dependent and independent pathways. Oncogene 11: 199-210
2. Smets L. A. (1994) Programmed cell death (apoptosis) and response to anti-cancer drugs. Anticancer Drugs 5: 3-9
3. Miyashita T. and Reed J. C. (1993) Bcl-2 gene transfer increases relative resistance of S49.1 and Wehi7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res. 52: 5407-5411
4. Reichard P. (1988) Interactions between deoxyribonucleotide and DNA synthesis. A. Rev. Biochem. 57: 349-374
5. Mathews C. K. and Ji J. (1992) DNA precursor asymmetries, replication fidelity and variable genome evolution. Bioassays 14: 295-301
6. Bradley M. O. and Sharkey N. A. (1978) Mutagenicity of thymidine to cultured Chinese hamster cells. Nature 274: 707-709
7. Brox L., Ng A., Pollock E. and Belch A. (1984) DNA strand breaks induced in human T-lymphocytes by the combination of deoxyadenosine and deoxycoformycin. Cancer Res. 44: 934-940
8. Yoshioka A., Tanaka S., Hiraoka O., Koyama Y., Hirota Y., Ayusawa D., Seno T., Garret C. and Wataya Y. (1987) Deoxyribonucleoside triphosphate imbalance. 5′-fluor, 2′-deoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J. Biol. Chem. 262: 8235-8241
9. Martin D. W. and Gelfand E. W. (1991) Biochemistry of diseases of immunodevelopment. A. Rev. Biochem. 50: 845-877
10. Oliver F. J., Marvel J., Collins M. K. L. and López-Rivas A. (1993) Bcl-2 oncogene protects a bone marrow-derived pre-B cell line from 5′-fluor, 2′-deoxyuridine-induced apoptosis. Biochem. Biophys. Res. Commun. 194: 126-132
11. Oliver F. J., Collins M. K. L. and López-Rivas A. (1996) Regulation of the salvage pathway of deoxynucleotides synthesis in apoptosis induced by growth factor deprivation. Biochem. J. 316: 421-425
12. Elledge S. J., Zhou Z. and Allen J. (1992) Ribonucleotide reductase: regulation, regulation, regulation. TIBS 17: 119-122
13. Kit S., Leung W.-C., Trkula D. and Jorgensen G. (1974) Gel electrophoresis and isoelectric focusing of mitochondrial and viral induced thymidine kinase. Int. J. Cancer 13: 203-218
14. Chang Z.-F. and Huang D.-Y. (1993) The regulation of thymidine kinase in HL-60 human promyeloleukemia cells. J. Biol. Chem. 268: 1266-1271
15. Gower W. R. Jr. Carr M. C. and Ives D. H. (1979) Deoxyguanosine kinase: distinct molecular form in mitochondria and cytosol. J. Biol. Chem 254: 2180-2183
16. DeGregory J., Kowalik T. and Nevins J. R. (1995) Cellular targets for activation by the E2F1 transcription factor include DNA synthesis and G1/S-regulatory genes. Mol. Cell Biol. 15: 4215-4224
17. Weimberg G., Ullman B., Martin B. W. Jr. (1981) Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools. Proc. Natl Acad. Sci. USA 78: 2447-2451
18. Reddy G. P. and Pardee A. B. (1980) Multienzyme complex for metabolic channeling in mammalian DNA replication. Proc. Natl Acad. Sci. USA 77: 3312-3316
19. Mattano S. S., Palella T. D. and Mitchell B. S. (1990) Mutations induced at the hypoxanthine-guanine phosphoribosyl-transferase locus of human T-lymphoblast by perturbations in purine deoxyribonucleotide triphosphate pools. Cancer Res. 50: 45-66
20. Daré E., Zhang H., Jenssen D. and Bianchi V. (1995) Molecular analysis in the hprt gene of V79 hamster fibroblasts: effects of imbalances in the dCTP, dGTP and dTTP pools. J. Molec. Biol. 252: 514-521
21. Kunz B. A. and Kohalmi S. E. (1991) Modulation of mutagenesis by deoxyribonucleotide levels. A. Rev. Genet. 25: 339-359
22. Phear G. and Meuth M. (1989) The genetic consequences of DNA precursor pool imbalance: sequence analysis of mutations induced by excess thymidine at the hamster aprt locus. Mutat. Res 214: 201-206
23. Kohalmi S. E., Glatke M., McIntosh E. M. and Kunz B. A. (1991) Mutational specificity of DNA precursor pool imbalances in yeast arising from deoxycytidylate deaminase deficiency or treatment with thymidylatc. J. Molec. Biol 220: 933-946
24. Snyder R. D. (1985) Effect of nucleotide pool imbalances on the excision repair of ultraviolet-induced damage in the DNA of human diploid fibroblasts. Basic Life Sci. 31: 163-173
25. Iwata N., Omine M., Yamauchi H. and Maekawa T. (1982) Characteristic abnormality of deoxyribonucleoside triphosphate metabolism in megaloblastic anemia. Blood 60: 918-923
26. Haynes R. H. and Kunz B. A. (1985) Possible role for deoxyribonucleotide pool imbalances in carcinogenesis. Basic Life Sci. 34: 156-157
27. Martin D. W. and Gelfand B. W. (1981) Biochemistry of diseases of immunodevelopment. A. Rev. Biochem. 50: 845-887
28. Yoshioka A., Tanaka S., Hiraoka O., Koyama Y., Hirola Y., Ayusawa D., Seno T., Garret C. and Wataya Y. (1987) Deoxyribonucleoside triphosphate imbalance. 5′-fluor, 2′-deoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J. Biol. Chem. 262: 8235-8241
29. Meuth M. (1989). The molecular basis of mutations induced by dNTP pool imbalances in mammalian cells. Expl Cell Res 181: 305-316
30. Ingraham H. A., Dickey L. and Goulian M. (1986) DNA fragmentation and cytotoxicity from increased cellular deoxyuridilate. Biochemistry 25: 3225-3230
31. Canman C. E., Radany E. H., Parsels L. A., Davis M. A., Lawrence T. H. and Maybaum J. (1994) Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of E. coli deoxyuridine triphosphatase. Cancer Res. 54: 2296-2298
32. Lagergren J. and Reichard P. (1987) Purine deoxyribonucleosides counteract effects of hydroxyurea on deoxyribonucleoside triphosphate pools and DNA synthesis. Biochem. Pharmacol. 36: 2985-2991
33. Koury M. J. and Horne D. W. (1994) Apoptosis mediates and thymidine prevents erythroblast destruction in folate deficiency. Proc. Natl Acad. Sci. USA 91: 4067-4071
34. Miyashita T. and Reed J. C. (1993) Bcl-2 gene transfer increases relative resistance of S49.1 and Wehi7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res. 52: 5407-5411
35. Almasan A., Yin Y., Kelly R. E., Lee, E. Y., Bradley A., Li W., Bertino J. R. and Wahl G. M. (1995) Deficiency of retinoblastoma protein leads to inappropiate S-phase, activation of E2F responsive genes, and apoptosis. Proc. Natl Acad. Sci. USA 92: 5436-5440
36. Collins M. K. L., Marvel J., Malde P. and López-Rivas A. (1992) Interleukin-3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents. J. Expl Med. 176: 1043-1051
37. Rodriguez-Tarduchy G., Collins M. K. L. and Lopez-Rivas A. (1990) Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores. EMBO J. 9: 2997-3002
38. Yusa T., Yamaguchi Y., Ohwada H., Hayashi Y., Monta T., Asanagi M., Moriyama I. and Fujimura S. (1988) Activity of the cytosolic isozyme of thymidine kinase in human primary lung tumors with reference to malignancy. Cancer Res. 48: 5001-5006
39. Hallek M., Wanders L., Strohmeyer S. and Emmerich B. (1992) Thymidine kinase: a tumor marker with prognostic value for non-Hodgkin's lymphoma and a broad range of potential clinical applications. Ann. Hematol 65: 1-5
40. Prokocimer M. and Rotter V. (1994) Structure and function of p53 normal cells and their aberrations in cancer cels: projection on the hematologic cell lineages. Blood 84: 2391-2411