Potential Role of IGF-I in Hypoxia Tolerance Using A Rat Hypoxic-Ischemic Model: Activation of Hypoxia-Inducible Factor 1α

Pediatric Research

Volumn 55, Issue 3, 2004, Pages 385-394

  Wang, Xinghe ^a   Deng, Jixian ^a,b   Boyle, David W ^d   Zhong, Jin ^a   Lee, Wei Hua ^a,c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^c INDIANA UNIVERSITY MEDICAL CENTER   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; OXYGEN; SOMATOMEDIN C;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; CELL SURVIVAL; CONTROLLED STUDY; DNA BINDING; ELECTROPHORETIC MOBILITY; GENE EXPRESSION; HIPPOCAMPUS; HISTOCHEMISTRY; HYPOXIA; IN SITU HYBRIDIZATION; ISCHEMIA; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANOXIA; APOPTOSIS; BASE SEQUENCE; CELL SURVIVAL; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HIPPOCAMPUS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; HYPOXIA-ISCHEMIA, BRAIN; IN SITU HYBRIDIZATION; INSULIN-LIKE GROWTH FACTOR I; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; THALAMUS; TRANSCRIPTION FACTORS;

EID: 1242319525     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000111482.43827.40     Document Type: Article

References (45)

1. Ruscher K, Isaev N, Trendelenburg G, Weih M, Iurato L, Meisel A, Dirnagl U 1998 Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons. Neurosci Lett 254:117-120
2. Perez-Pinzon MA, Mumford PL, Rosenthal M, Sick TJ 1996 Anoxic preconditioning in hippocampal slices: role of adenosine. Neuroscience 75:687-694
3. Gidday JM, Fitzgibbons JC, Shah AR, Park TS 1994 Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat. Neurosci Lett 168:221-224
4. Vannucci RC, Towfighi J, Vannucci SJ 1998 Hypoxic preconditioning and hypoxic-ischemic brain damage in the immature rat: pathologic and metabolic correlates. J Neurochem 71:1215-1220
5. Miller BA, Perez RS, Shah AR, Gonzales ER, Park RS, Gidday JM 2001 Cerebral protection by hypoxic preconditioning in a murine model of focal ischemia-reperfusion. Neuroreport 12:1663-1669
6. Bernaudin M, Nedelec A-S, Divoux D, MacKenzie ER, Petit E, Schumann-Bard P 2002 Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult brain. J Cereb Blood Flow Metab 22:393-403
7. Chen J, Simon R 1997 Ischemic tolerance in the brain. Neurology 48:306-311
8. Xu G-P, Dave KR, Vivero R, Schmidt-Kastner R, Sick TJ, Perez-Pinzon MA 2002 Improvement in neuronal survival after ischemic preconditioning in hippocampal slice cultures. Brain Res 952:153-158
9. Kobayashi S, Harris VA, Welsh FA 1995 Spreading depression induces tolerance of cortical neurons to ischemia in rat brain. J Cereb Blood Flow Metab 15:721-727
10. Riepe MW, Ludolph AC 1997 Chemical preconditioning: a cytoprotective strategy. Mol Cell Biochem 174:249-254
11. Sizonenko SV, Sirimanne ES, Williams CE, Gluckman PD 2001 Neuroprotective effects of the N-terminal tripeptide of IGF-1, glycine-proline-glutamate, in the immature rat brain after hypoxic-ischemic injury. Brain Res 922:42-50
12. Gluckman PD, Guan J, Williams C, Scheepens A, Zhang R, Bennet L, Gunn A 1998 Asphyxial brain injury-the role of the IGF system. Mol Cell Endocrinol 140:95-99
13. Gluckman P, Klempt N, Guan J, Mallard C, Sirimanne E, Dragunow M, Klempt M, Singh K, Williams C, Nikolics K 1992 A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury. Biochem Biophys Res Commun 182:593-599
14. Guan J, Williams C, Gunning M, Mallard C, Gluckman P 1993 The effects of IGF-1 treatment after hypoxic-ischemic brain injury in adult rats. J Cereb Blood Flow Metab 13:609-616
15. Guan J, Williams CE, Skinner SJ, Mallard EC, Gluckman PD 1996 The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins. Endocrinology 137:893-898
16. Guan J, Skinner SJ, Beilharz EJ, Hua KM, Hodgkinson S, Gluckman PD, Williams CE 1996 The movement of IGF-I into the brain parenchyma after hypoxic-ischaemic injury. Neuroreport 7:632-636
17. Guan J, Miller OT, Waugh KM, McCarthy DC, Gluckman PD 2001 Insulin-like growth factor-1 improves somatosensory function and reduces the extent of cortical infarction and ongoing neuronal loss after hypoxia-ischemia in rats. Neuroscience 105:299-306
18. Lee W-H, Wang G-M, Seaman LB, Vannucci SJ 1996 Coordinate IGF-1 and IGFBP5 gene expression in perinatal rat brain after hypoxia-ischemia. J Cereb Blood Flow Metab 16:227-236
19. Clawson TF, Vannucci SJ, Wang G-M, Seaman LB, Yang X-L, Lee W-H 1999 Hypoxia-ischemia-induced apoptotic cell death correlates with IGF-I mRNA decrease in neonatal rat brain. Biol Signals Recept 8:281-293
20. Johnston BM, Mallard EC, Williams CE, Gluckman PD 1996 Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs. J Clin Invest 97:300-308
21. Wang GL, Semenza GL 1995 Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270:1230-1237
22. 2 tension. Proc Natl Acad Sci U S A 92:5510-5514
23. 2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15:551-578
24. 2 sensing. Science 292:464-472
25. Lando D, Peet DJ, Whelan DA, Corman JJ, Whitelaw ML 2002 Asparagine hydroxylation of the HIF transactivation domain: a hypoxic switch. Science 295:858-861
26. Scalceda S, Caro J 1997 Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redo-induced changes. J Biol Chem 272:22642-22647
27. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A 95:7987-7992
28. 2 tension. Am J Physiol 271:C1172-C1180
29. Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR 2000 Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol 48:285-296
30. Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, Cohen B 1998 Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. EMBO J 17:5085-5094
31. Tazuke SI, Mazure NM, Sugawara J, Carland G, Faessen GH, Suen LF, Irwin JC, Powell DR, Giaccia AJ, Giudice LC 1998 Hypoxia stimulates insulin-like growth factor binding protein (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proc Natl Acad Sci U S A 95:10188-10193
32. Chavez JC, LaManna JC 2002 Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1. J Neurosci 22:8922-8931
33. Rice JE, III, Vannucci RC, Brierley JB 1981 The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 9:131-141
34. Bondy CA 1991 Transient IGF-I gene expression during the maturation of functionally related central projection neurons. J Neurosci 11:3442-3455
35. Wenger RH 2000 Mammalian oxygen sensing, signalling and gene regulation. J Exp Biol 203:1253-1263
36. Bondy C, Werner H, Roberts Jr CT, LeRoith D 1992 Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II. Neuroscience 46:909-923
37. Coculescu M 1999 Blood-brain barrier for human growth hormone and insulin-like growth factor-1. J Pediatr Endocrinol Metab 12:113-124
38. Shoba L, An MR, Frank SJ, Lowe Jr WL 1999 Developmental regulation of insulin-like growth factor-I and growth hormone receptor gene expression. Mol Cell Endocrinol 152:125-136
39. Calikoglu A, Karayal A, D'Ercole AJ 2001 Nutritional regulation of IGF-I expression during brain development in mice. Pediatr Res 49:197-202
40. Ye P, Umayahara Y, Ritter D, Bunting T, Auman H, Rotwein P, D'Ercole AJ 1997 Regulation of insulin-like growth factor I (IGF-I) gene expression in brain of transgenic mice expressing an IGF-I-luciferase fusion gene. Endocrinology 138:5466-5475
41. Lee W-H, Clemens JA, Bondy CA 1992 Insulin-like growth factors in the response to cerebral ischemia. Mol Cell Neurosci 3:36-43
42. Zhong J, Deng J, Ghetti B, Lee W-H 2002 Inhibition of insulin-like growth factor I activity contributes to the premature apoptosis of cerebellar granule neuron in weaver mutant mice: in vitro analysis. J Neurosci Res 70:36-45
43. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME 1997 Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-664
44. Datta SR, Brunet A, Greenberg ME 1999 Cellular survival: a play in three Akts. Genes Dev 13:2905-2927
45. Daughaday WH, Rotwein P 1989 Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev 10:68-91