Addition of anti-CD28 antibodies restores PBMC proliferation and IFN-γ production in lepromatous leprosy patients

Journal of Interferon and Cytokine Research

Volumn 19, Issue 11, 1999, Pages 1237-1243

  Fafutis Morris, Mary ^a,b   Guillén Vargas, Cecilia M ^a   Navarro Fierros, Sergio ^a   Alfaro Bustamante, Fernando ^b   Zaitzeva Petrovna, Galina ^b   Daneri Navarro, Adrian ^b   Santoscoy Tovar, Luis ^c   Armendariz Borunda, Juan ^b  

^a INSTITUTO DERMATOLÓGICO DE JALISCO DR JOSÉ BARBA RUBIO   (Mexico)

^b UNIVERSITY OF GUADALAJARA   (Mexico)

^c Unidad de Patologia Clinica   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; GAMMA INTERFERON; MONOCLONAL ANTIBODY; PHYTOHEMAGGLUTININ;

ADULT; AGED; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CYTOKINE PRODUCTION; FEMALE; HUMAN; LEPROMATOUS LEPROSY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MONONUCLEAR CELL; MYCOBACTERIUM LEPRAE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; B LYMPHOCYTE; BIOSYNTHESIS; CELL DIVISION; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD80; B-LYMPHOCYTES; CELL DIVISION; FEMALE; HUMANS; INTERFERON TYPE II; LEPROSY, LEPROMATOUS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PHYTOHEMAGGLUTININS; T-LYMPHOCYTES;

EID: 0032589964     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999099312894     Document Type: Article

References (27)

1. ISLAS, R.A.E., MORALES, O.K., FAFUTIS, M.M., GONZALEZ, M.A., and ORTIZ, O.L. (1987). Deficiency in the biosynthesis of interleukin 2 (IL-2) and functional presence of the IL-2 receptor in lepromatous leprosy. Int. J. Lepr. 55, 566-569.
2. MUNNO, I., PELLEGRINO, N.M., FUMO, G., BARBIERI, G., and JIRILLO, E. (1990). Studies on lymphokine production in lepromatous leprosy patients. Cytobios 62, 141-147.
3. OCHOA, M.T., VALDERRAMA, L., OCHOA, A., ZEA, A., ESCOBAR, C.E., MORENO, L.H., and FALABELA, R. (1996). Lepromatous and tuberculoid leprosy: clinical presentation and cytokine responses. Int. J. Dermatol. 35, 786-790.
4. IVANYI, J. (1986). Pathogenic and protective interactions in mycobacterial infections. Clin. Immunol. Allergy 6, 127-154.
5. MEHRA, V., MASON, L.H., ROTHMAN, W., REINJERZ, E., SCHOLOSSMAN, S.F., and BLOOM, B.R. (1980). Delineation of a human T cell subset responsible for lepromine induced suppression in leprosy patients. J. Immunol. 125, 1183-1188.
6. MOHAGHEPOUR, N., GELBER, R.H., and ENGELMAN, E.T. (1987). T cell defect in lepromatous leprosy is reversible in vitro in the absence of exogenous growth factors. J. Immunol. 138, 570-574.
7. NOGUEIRA, N., KAPLAN, G., LEVY, E., SARNO, E.N., KUSHNER, P., GARNELLI-PIPERNI, A., VIERIRA, L., COLOMER, A., COULD, V., LEVIS, W., STEINMAN, R., YIP, Y.K., and COHN, Z.A. (1983). Defective low interferon production in leprosy reversal with antigen and interleukin 2. J. Exp. Med. 158, 2165-2170.
8. FAFUTIS, M.M., ALFARO, B.F., GONZALEZ, M.A., MORALES, O.R., and ISLAS, R.A.E. (1991). Response to phyto-hemagglutinin of LL patients' lymphocytes preincubated in culture media. Int. J. Lepr. 59, 480-482.
9. LENSCHOW, D.J., WALUNAS, T.L., and BLUESTONE, J.A. (1996). CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14, 233-258.
10. REISER, H., and STADECKER, M.J. (1996). Mechanisms of disease: costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases. N. Engl. J. Med. 335, 1369-1377.
11. LINSLEY, P.S., BRADY, W., GROSMAIRE, L., ARUFFO, A., DAMLE, N.K., and LEDBETTER, J.A. (1991). Binding of the B cell activation B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173, 721-730.
12. RIDLEY, D.S., and JOPLING, W.H. (1996). Classification of leprosy according to immunity; a five group system. Int. J. Lepr. 34, 255-273.
13. WORLD HEALTH ORGANIZATION. (1997). Progress towards leprosy elimination. Weekly Epidemiol. Rec. 72, 165-172.
14. BOYUM, A. (1968). Isolation of mononuclear cells and granulocytes from human blood. Isolation of cells by one centrifugation, and of granuloctyes by combining centrifugation, and sedimentation at 1g. Scand. J. Clin. Lab. Invest. 21(Suppl 97), 77-89.
15. ISLAM, D., LINDBER, A.A., and CHRISTENSSON, B. (1995). Peripheral blood cell preparation influences the level of expression of leukocyte cell surface markers as assessed with quantitative multicolor flow cytometry. Cytometry 22, 128-134.
16. FREEMAN, G.J., GRAY, G.S., GIMMI, C.D., LOMBARD, D.B., ZHOU, L.J., WHITE, M., FIZGEROTH, J.D., GRIEBEN, J.G., and NADLER, L.M. (1991). Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. J. Exp. Med. 174, 625-631.
17. SALGAME, P.R., TANNAZ, J.B., MAHADEVAN, P.R., and ANTIA, N.H. (1980). Role of macrophages in defective cell-mediated immunity in lepromatous leprosy. I. Factor(s) from macrophages affecting protein synthesis and lymphocyte transformation. Int. J. Lepr. 48, 172-177.
18. + T cell responses in the human leprosy. J. Immunol. 161, 2407-2413.
19. AGREWALA, J.N., KUMAR, B., and VOHRA, H. (1998). Potential role of B7-2 and CD28 molecules in immunosuppression in leprosy. Clin. Exp. Immunol. 111, 56-63.
20. SATISH, M., BHUTANI, L.K., SHARMA, A.K., and NATH, I. (1983). Monocyte-derived soluble suppressor factor(s) in patients with leprosy. Infect. Immun. 42, 890-896.
21. SAHA, B., DAS, G., VOHRA, H., GANGULY, N.K., and MISHRA, G.C. (1994). Macrophage-T cell interaction in experimental mycobacterial infection. Selective regulation of costimulatory molecules of Mycobacterium-infected macrophages and its implication in the suppression of cell-mediated immunity. Eur. J. Immunol. 24, 2618-2624.
22. HORWITZ, M.A., LEVIS, W.R., and COHN, Z.A. (1984). Defective produciton of monocyte activating cytokines in lepromatous leprosy. J. Exp. Med. 159, 666-678.
23. HERNANDEZ, H.J., SHARPE, A.H., and STADECKER, M.J. (1999). Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation. J. Immunol. 162, 2884-2889.
24. TAYOR-ROBINSON, A.W., and SMITH, B.C. (1999). Modulation of experimental blood stage malaria through blockade of the B7/CD28 T-costimulatory pathway. Immunology 96, 498-504.
25. CHAMBERS, C.A., KRUMMEL, M.F., BIOTEL, B., HURWITZ, A., SULLIVAN, T.J., FOURNIER, S., CASSELL, D., BRUNNER, M., and ALLISON, J.P. (1996). The role of CTLA-4 in the regulation and initiation of T-cell responses. Immunol. Rev. 153, 27-47.
26. AGREWALA, J.N., SUVAS, S., VERMA, R.K., and MISHRA, G.C. (1998). Differential effect of anit-B7-1 and anti-M150 antibodies in restricting the delivery of costimulatory signals from B cells and macrophages J. Immunol. 160, 1067-1077.
27. SCHWEITZER, A.N., and SHARPE, A.H. (1998). Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus re-stimulation of Th2 but not Th1 cytokine production. J. Immunol. 161, 2762-2771.