Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 5, 2004, Pages 1269-1272

  Wang, Yan ^a   Huang, Jin Chen ^b   Zhou, Zhang Lin ^b   Yang, Wu ^a   Guastella, John ^a,c   Drewe, John ^a   Cai, Sui Xiong ^a  

^a Maxim Pharmaceuticals Inc   (United States)

^b Department of Pharmacokinetics and Drug Metabolism   (United States)

^c Insert Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ASPARTIC ACID; CARBOXYLIC ACID; CASPASE 3 INHIBITOR; KETONE DERIVATIVE; PROTEINASE; VALINE;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; INHIBITION KINETICS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 1242293893     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.12.065     Document Type: Article

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