Protective effect of tripchlorolide on dopaminergic neurons in partially lesioned rat model of Parkinson's disease

Yaoxue Xuebao

Volumn 37, Issue 5, 2002, Pages 339-342

  Cheng, Xiao Xin ^a,b   Li, Feng Qiao ^a   Huang, Min ^b   Wang, Xiao Min ^a   Han, Ji Sheng ^a  

^a PEKING UNIVERSITY   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Dopamine; Immunosuppressant; Neuroprotection; Parkinson's disease; Tripchlorolide

Indexed keywords

DITERPENE; DOPAMINE; HERBACEOUS AGENT; INTERLEUKIN 2; NEUROPROTECTIVE AGENT; PHENANTHRENE DERIVATIVE; TRIPCHLOROLIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; BRAIN; CORPUS STRIATUM; DRUG EFFECT; MALE; METABOLISM; NERVE CELL; PARKINSON DISEASE; PATHOPHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CORPUS STRIATUM; DITERPENES; DOPAMINE; DRUGS, CHINESE HERBAL; INTERLEUKIN-2; MALE; NEURONS; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0041881863     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Mogi M, Harada M, Narabayashi H, et al. Interleukin (IL)-1β, IL-2, IL-4, IL-6, and transforming growth factor-α levels are elevated in ventricular cerebrospinal fluid in juvenile Parkinsonism and Parkinson's disease [J]. Neurosci Lett, 1996,211(1):13-16.
2. Mogi M, Harada M, Riederer P, et al. Tumor necrosis factor-α (TNF-α) increase both in the brain and in the cerebrospinal fluid from Parkinsonian patients [J]. Neurosci Lett, 1994,165(1-2):208-210.
3. Kuhn W, Muller T, Nastos I, et al. The neuroimmune hypthesis in Parkinson's disease [J]. Neuroscience, 1997, 8 (1):29-34.
4. Snyder SH, Sabatini DM, Michael ML, et al. Neural actions of immunophilin ligands [J]. TIPS, 1998,19(1):21-26.
5. Ding WL, Liu DM, Wen W. Effect of Tripterygium wilfordii hook on nerve regeneration after heterografting [J]. Acta Anat Sin (m®¥&). 1999,30(1):31-43.
6. Knusel B, Beck KD, Winslow JW, et al. Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain [J]. J Neurosci, 1992,12(11):4391-4402.
7. Lapchak PA, Beck KD, Araujo DM, et al. Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebain bundle transection [J]. Neuroscience, 1993, 53(3): 639-650.
8. Ungerstedt U, Arbuthnett GW. Quantitative recording of rotational behavior in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system [J]. Brain Res, 1970,24 (3): 458-493.
9. Gang YY, Zhang ZX. Progresses of pharmacological studies of Tripterygium wilfordii Hook and its minomers [J]. J China Pharm Univ, 1995, 26(4): 252-256.
10. Youdim MB, Riederer P. Understanding Parkinson's disease [J]. Sci Am, 1997,276(1):52-59.
11. McGeer EG, McGeer PL. The role of the immune system in neurodegenerative disorders [J]. Mov Disord, 1997, 12(6): 855-858.
12. Chang RC, Hudson P, Wilson B, et al . Influence of neurons on lipopolysaccharide-stimulated production of nitric oxide and tumor necrosis factor-alpha by cultured glia [J]. Brain Res. 2000, 853(2): 236-244.
13. Revuelta M, Venero JI, Machado A, et al. Serotonin hyperinnervation in the adult rat ventral mesencephalon following unilateral transection of the medial forebrain bundle. Correlaction with reactive microglia and astroglial populations [J]. Neuroscience, 1999, 91(2): 567-577.
14. Mogi M, Togari A, Tanaka K, et al. Increase in level of tumor necrosis factor-α in 6-hydroxydopamine-lesioned striatum in rats suppressed by immunosuppressant FK506 [J]. Neurosci Lett, 2000, 289(3) : 165-168.