Formulation of a microparticle carrier for oral polyplex-based DNA vaccines

Biochimica et Biophysica Acta - General Subjects

Volumn 1674, Issue 2, 2004, Pages 149-157

  Howard, Kenneth A ^a   Li, Xiong Wei ^a   Somavarapu, Satyanarayana ^a   Singh, Jasvinder ^a   Green, Nicky ^b   Atuah, Kwame N ^a   Ozsoy, Yildiz ^c   Seymour, Leonard W ^b   Alpar, H Oya ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ISTANBUL UNIVERSITY   (Turkey)

Author keywords

DNA; Gene delivery; Microparticle; Oral; PLGA; Polyethylenimine; Polyplex

Indexed keywords

BETA GALACTOSIDASE; DNA VACCINE; DRUG CARRIER; HEPARIN; LUCIFERASE; MACROGOL; PLASMID DNA; POLYASPARTIC ACID; POLYELECTROLYTE; POLYETHYLENEIMINE; POLYGLACTIN; POLYMER; DNA; LACTIC ACID; MACROGOL DERIVATIVE; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL EXPERIMENT; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DEGRADATION; DRUG FORMULATION; DRUG RELEASE; ELECTRON MICROSCOPY; EMULSION; ENCAPSULATION; EVAPORATION; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; TRANSGENE; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; GENE EXPRESSION REGULATION; IMMUNE SYSTEM; IMMUNOLOGY; METABOLISM; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; WISTAR RAT;

PAA; RATTUS NORVEGICUS;

ADMINISTRATION, ORAL; ANIMALS; DNA; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GENE EXPRESSION REGULATION; IMMUNE SYSTEM; LACTIC ACID; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, WISTAR; VACCINES, DNA;

EID: 12344321080     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2004.06.009     Document Type: Article

References (25)

1. Davis H.L., McCluskie M.J. DNA vaccines for viral diseases. Microbes Infect. 1:1999;7-21
2. Huygen K. On the use of DNA vaccines for the prophylaxis of mycobacterial diseases. Infect. Immun. 71:(4):2003;1613-1621
3. Mc Gee J.R., Kiyona H. New perspectives in vaccine development: mucosal immunity to infections. Infect. Agents Dis. 2:1993;55-73
4. Kaiserlian D., Etchart N. Semin. Immunol. 11:1999;217-224
5. Dash P.R., Seymour L.W. Pharmaceutical aspects of gene therapy. Chiellini E., Sunamoto J., Migliaresi C., Ottenbrite M., Cohn D. Biomedical Polymers and Polymer Therapeutics. 2001;341-349 Kluwer Academic/Plenum Publishers, Dordrecht
6. Kabanov A.V., Felgner P.L., Seymour L.W. Self-Assembling Vectors for Gene Therapy: From Basic Science to Clinical Applications. 1998;46-53 Wiley, New York
7. Boussif O., Lezoualc'h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., Behr J.P. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. U. S. A. 92:1995;7297-7301
8. Diebold S.S., Kursa M., Wagner E., Cotton M., Zenke M. MHC class II presentation of endogenously expressed antigens by transfected dendritic cells. Gene Ther. 8:1999;487-493
9. Watts P.J., Davies M.C., Melia C.D. Microencapsulation using emulsification/solvent evaporation: an overview of techniques and applications. Crit. Rev. Ther. Drug Carr. Syst. 7:1990;235-259
10. Howard K.A., Thomas N.W., Jenkins P.G., Davis S.S., O'Hagan D.T. The absorption of microparticles into Peyer's patches in the rabbit and rat. Pharm. Sci. Commun. 4:1994;207-216
11. Partidos C.D., Vohra P., Jones D.H., Farrar G., Steward M.W. Induction of cytotoxic T-cell responses following oral immunization with synthetic peptides encapsulated in PLG microparticles. J. Cont. Rel. 62:1999;325-332
12. Hedley M.L., Curley J., Urban R. Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses. Nat. Med. 4:1998;365-368
13. Cohen H., Levy R.J., Gao J., Fishbein I., Kousaev V., Sosnowski S., Slomkowski S., Golomb G. Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles. Gene Ther. 7:2000;1896-1905
14. Capan Y., Woo B.H., Gebrekidan S., Ahmed S., DeLuca P. Influence of formulation parameters on the characteristics of poly(D,L-lactide-co-glycolide) microspheres containing poly(L-lysine) complexed plasmid DNA. J. Cont. Rel. 60:1999;279-286
15. De Rosa G., Bochot A., Quaglia F., Besnard M., Fattal E. A new delivery system for antisense therapy: PLGA microspheres encapsulating oligonucleotide/polyethyleneimine solid complexes. Int. J. Pharm. 254:2003;89-93
16. Howard K.A., Dash P.R., Read M.L., Ward K., Tomkins L.M., Nazarova O., Ulbrich K., Seymour L.W. Influence of hydrophilicity of cationic polymers on the biophysical properties of polyelectrolyte complexes formed by self-assembly with DNA. Biochim. Biophys. Acta. 1475:2000;245-255
17. Wang D., Robinson D.R., Kwon G.S., Samuel J. Encapsulation of plasmid DNA in biodegradable poly(D,L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. J. Cont. Rel. 57:1999;9-18
18. Kaneko H., Bednarek I., Wierzbicki A., Kiszka I., Dmochowski M., Wasik T.J., Kaneko Y., Kozbor D. Oral DNA vaccination promotes mucosal and systemic immune responses to HIV envelope glycoprotein. Virology. 267:2000;8-16
19. Panyam J., Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 55:2003;329-347
20. Walter E., Moelling K., Pavlovic J., Merkle H.P. Microencapsulation of DNA using poly(DL-lactide-co-glycolide): stability issues and release characteristics. J. Cont. Rel. 61:1999;361-374
21. Manuel W.S., Zheng J., Hornsby P.J. Transfection by polyethyleneimine- coated microspheres. J. Drug Target. 9:2001;15-22
22. Thiele L., Merkle H.P., Walter E. Phagocytosis and phagosomal fate of surface-modified microparticles in dendritic cells and macrophages. Pharm. Res. 20:2003;221-228
23. Ogris M., Walker G., Blessing T., Kircheis R., Wolschek M., Wagner E. Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes. J. Cont. Rel. 91:2003;173-181
24. Mathlowitz E., Jacob J.S., Jong Y.S., Carino G.P., Chickering D.E., Chaturvedi P., Santos C.A., Vijayaraghaven K., Montgomery S., Bassett M., Morell C. Biologically erodable microspheres as potential oral drug delivery systems. Nature. 386:1997;410-414
25. Eldridge J.H., Hammond C.J., Meulbroek J.A., Staas J.K., Gilley R.M., Tice T.R. Controlled vaccine release in the gut-associated lymphoid tissues: I. Orally administered biodegradable microspheres target the Peyer's patches. J. Cont. Rel. 11:1990;205-214