In-vivo effects of the 1,2,4-piperazine derivatives MM5 and MC1, putative 5-HT agonists, on dopamine and serotonin release in rat prefronfal cortex

Journal of Pharmacy and Pharmacology

Volumn 57, Issue 2, 2005, Pages 205-211

  Iskra Jopa, Joanna ^a   Gołembiowska, Krystyna ^c   Dziubina, Anna ^c   Cybulski, Marcin ^a   Duszyńska, Beata ^c   Chilmonczyk, Zdzisław ^b  

^a INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE   (Poland)

^b NATIONAL MEDICINES INSTITUTE   (Poland)

^c INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 (2 METHYL 4 QUINOLIN 2 YLPIPERAZIN 1 YL)BUTYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; 1 [4 (4 QUINOLIN 2 YLPIPERAZIN 1 YL)BUTYL]PIPERIDIN 2 ONE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3,4 DIHYDROXYPHENYLACETIC ACID; DOPAMINE; HOMOVANILLIC ACID; MC 1; MM 5; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PIPERAZINE DERIVATIVE; RITANSERIN; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2 ANTAGONIST; SEROTONIN AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC ACTIVITY; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; HYPOTHERMIA; IN VITRO STUDY; MALE; NONHUMAN; PREFRONTAL CORTEX; RAT; SEROTONIN RELEASE;

3,4-DIHYDROXYPHENYLACETIC ACID; 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; DOPAMINE; EXTRACELLULAR FLUID; HOMOVANILLIC ACID; MALE; MICRODIALYSIS; PIPERAZINES; PIPERIDONES; POLAND; PREFRONTAL CORTEX; PYRIDINES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; RITANSERIN; SEROTONIN; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 12344289187     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357055425     Document Type: Article

References (47)

1. 2 receptor regulation of extracellular levels in the prefrontal cortex. Neuropsychpharmacology 20: 92-96
2. 1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex, Neuropharmacology 45: 1050-1056
3. 2A receptors in pyramidal neurons of prefrontal cortex. Cereb. Cortex 14: 281-299
4. 3-like receptors. Synapse 10: 7-15
5. Barnes, N. M., Sharp, T. (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38: 1083-1152
6. 1A receptor antagonist WAY 100635 in non-human primates. Eur. J. Pharmacol. 482: 197-203
7. 1A receptors induces lower lip retraction in rats. Psychopharmacology 101: 57-61
8. 2A receptor affinity of some 2- and 3-substituted 1,2,3,4-tetrahydro-β-carbolines. Pharmazie 48: 289-294
9. Casanovas, J. M., Artigas, F. (1996) Differential effects of ipsapirone on 5-hydroxytryptamine release in the dorsal and median raphe neuronal pathways. J. Neurochem. 67: 1945-1952
10. 1A receptors control 5-HT release in the rat medial prefrontal cortex. Neuroreport 10: 1441-1445
11. A, and glutamate receptors. J. Neurosci. 21: 9917-9929
12. Chen, N.-H., Reith, E. A. (1995) Monoamine interactions measured by microdialysis in the ventral tegmental area of rats treated systematically with (±)-8-hydroxy-2-(di-n-propylamino)tetralin. J. Neurochem. 64: 1585-1597
13. 2A receptors. Il Farmaco 57: 285-301
14. 1A receptors in the anticonflict effect of ipsapirone in rats. Neuropharmacology 30: 703-709
15. Cobb, W. S., Abercrombie, E. D. (2003) Differential regulation of somatodendritic and nerve terminal dopamine release by serotonergic innervation of substantia nigra. J. Neurochem. 84: 576-584
16. 1A receptors might control the output of cortical glutamatergic neurons in rat cingulate cortex. Brain Res. 989: 42-51
17. Davidson, R. J. (2002) Anxiety and affective style: role of prefrontal cortex and amygdala. Biol. Psychiatry 51: 68-80
18. Descarries, L., Lemay, B., Doucet, G., Berger, B. (1987) Regional and laminar density of the dopamine innervation in adult rat cerebral cortex. Neuroscience 21: 807-882
19. 1B receptors. Neuropsychopharmacology 21: 268-284
20. 2A receptor activation enhances dialysate levels of dopamine and noradrenaline, but not 5-HT, in the frontal cortex of freely-moving rats. Neuropharmacology 38: 315-317
21. Gobert, A., Rivet, J.-M., Audinot, V., Newman-Tancredi, A., Cistarelli, L., Millan, A. J. (1998) Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release. Neuroscience 84: 413-429
22. 2-adrenergic receptors underlies its action. Neuroscience 93: 1251-1262
23. 1A receptors. Neuropharmacology 45: 72-81
24. 1A receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release. J. Neurochem, 76: 1521-1531
25. 1A receptor agonism. Brain Res. 956: 349-357
26. Imperato, A., Di Chiara, G. (1984) Trans-striatal dialysis coupled to reverse phase high performance liquid chromatography with electrochemical detection: a new method for the study of the in vivo release of endogenous dopamine and metabolites. J. Neurosci. 4: 966-977
27. 1A receptor ligands exhibiting different response in in vivo animal models. The third multidisciplinary conference on drug research. Pila 13-16 May, p. 160
28. Iyer, R. N., Bradberry, C. W. (1996) Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization. J. Pharmacol. Exp. Ther. 277: 40-47
29. Jordan, S., Koprivica, V., Dunn, R., Tottori, K., Kikuchi, T., Altar, C. A. (2004) In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function. Eur. J. Pharmacol. 483: 45-53
30. 1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535. Synapse 30: 1-9
31. 1A agonists, partial agonists and antagonists in anxiety and, depression: a lost cause? Curr. Opin. CPNS Invest. Drugs 1: 448-452
32. 2A and group II metabotropic glutamate receptors in prefrontal cortex. J. Pharmacol. Exp. Ther. 292: 76-87
33. 1A autoreceptor function. In: Fozard, J. R., Saxena, P. R. (eds) Serotonin: molecular biology, receptors and functional effect. Birkhauser Verlag, Basel, pp 483-490
34. 2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo. Neuropharmacology 37: 953-955
35. Millan, M. J., Lejeune, F., Gobert, A. (2000) Reciprocal autoreceptor and heteroreceptor control of serotonergic, dopaminergic and noradrenergic transmission in the frontal cortex: relevance to the actions of antidepressant agents. J. Psychopharmacol. 14: 114-138
36. 2A receptors on dopaminergic cells in subnuclei of the midbrain A10 cell group. Neuroscience 111: 163-176
37. Ossowska, G., Nowak, G., Kata, R., Klenk-Mejewska, B., Danilczuk, Z., Żebrowska-Łupina, I. (2001) Brain monoamine receptors in a chronic unpredictable stress model in rats. J. Neural Transm. 108: 311-319
38. Paxinos, G., Watson, C. (1998) The rat brain in stereotaxic coordinates. Academic Press, San Diego
39. 2A antagonist, attenuates dopamine release in the rat medial prefrontal cortex. Brain Res. 888: 51-59
40. 1A receptor in the rat brain: correlation with receptor binding. J. Neurosci. 12: 440-453
41. 2C receptors. Molec. Brain Res. 23: 163-178
42. Steinbusch, H. W. (1981) Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 6: 557-618
43. 1a receptor and catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)-tetralin in the rat. Eur. J. Pharmacol. 106: 271-282
44. 1A receptors in the rat prefrontal cortex. Eur. J. Pharmacol. 305: 73-78
45. 1A receptor antagonists. Eur. J. Pharmacol. 471: 27-34
46. 1A-receptor antagonist with anxiolyitc-like activity, in mice and rats. J. Pharm. Pharmacol. 55: 533-543
47. 2A receptors are expressed on pyramidal cells and inter-neurons in the rat prefrontal cortex. Synapse 27: 79-82