Ipsapirone enhances the dopamine outflow via 5-HT1A receptors in the rat prefrontal cortex

European Journal of Pharmacology

Volumn 305, Issue 1-3, 1996, Pages 73-78

  Wȩdzony, Krzysztof ^a   Maćkowiak, Marzena ^a   Fijał, Katarzyna ^a   Gołembiowska, Krystyna ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

5 HT1A receptor; Cortex, prefrontal; Dopamine; Ipsapirone; Microdialysis; NAN 190; WAY 100135

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 1 PYRIMIDINYLPIPERAZINE; BUSPIRONE; DOPAMINE; DRUG METABOLITE; IPSAPIRONE; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; DRUG ANTAGONISM; DRUG SELECTIVITY; MALE; MICRODIALYSIS; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT;

3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; BUSPIRONE; DOPAMINE; HOMOVANILLIC ACID; MALE; MICRODIALYSIS; PIPERAZINES; PREFRONTAL CORTEX; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0029892485     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00150-1     Document Type: Article

References (40)

1. 1A receptor agonist, Neurosci. Lett. 170, 141.
2. 1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons, Naunyn-Schmied. Arch. Pharmacol. 347, 353.
3. 1A receptors: variations in intrinsic activity studied in transfected HeLa cells, Naunyn-Schmied. Arch. Pharmacol. 345, 257.
4. Carboni, E., G.L. Tanda, R. Frau and G. Di Chiara, 1990, Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals, J. Neurochem. 55, 1067.
5. 1A binding in rat brain - a combined in situ hybridisation/in vitro receptor autoradiographic study. Brain Res. 561, 51.
6. 1A receptors in the anticonflict effect of ipsapirone in rats. Neuropharmacology 30, 703.
7. 1A antagonist, with ipsapirone, Pharmacol. Biochem. Behav. 34, 927.
8. Deutch, A.Y., 1993, Prefrontal cortical dopamine systems and the elaboration of functional corticostriatal circuits: implications for schizophrenia and Parkinson's disease, J. Neural Transm. Gen. Sect. 91, 197.
9. Deutch, A.Y., S.Y. Tam and R.H. Roth, 1985, Footshock and conditioned stress increase 3,4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigra, Brain Res. 333, 143.
10. Deutch, A.Y., A.J. Bean, G. Bissette, C.B. Nemeroff, R.J. Robbins and R.H. Roth, 1987, Stress-induced alterations in neurotensin, somatostatin and corticotropin-releasing factor in mesotelencephalic dopamine system regions, Brain Res. 417, 350.
11. Deutch, A.Y., W.A. Clark and R.H. Roth, 1990, Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress, Brain Res. 521, 311.
12. 1A receptors. Eur. J. Pharmacol. 237, 283.
13. Goldstein, M. and A.Y. Deutch, 1992, Dopaminergic mechanisms in the pathogenesis of schizophrenia, FASEB J. 6, 2413.
14. Gonon, F.G. and M.J. Buda, 1985, Regulation of dopamine release by impulse flow and by autoreceptors as studied by in vivo voltammetry in the rat striatum, Neuroscience 14, 765.
15. Grace, A.A., 1993, Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia, J. Neural Transm. Gen. Sect. 91, 111.
16. Grenhoff, J., M. Nisell, S. Ferre, G. Aston Jones and T.H. Svensson, 1993, Noradrenergic modulation of midbrain dopamine cell firing elicited by stimulation of the locus coeruleus in the rat, J. Neural Transm. Gen. Sect. 93, 11.
17. Imperato, A. and G. Di Chiara, 1985, Dopamine release and metabolism in awake rats after systemic neuroleptics as studied by trans-striatal dialysis, J. Neurosci. 5, 297.
18. Koob, G.F. and F.E. Bloom, 1988, Cellular and molecular mechanisms of drug dependence, Science 242, 715.
19. 1A receptor ligands (+)-WAY 100 135 and SDZ 216-525. Eur. J. Pharmacol. 249, 25.
20. 1A receptor mRNA in the rat brain, Mol. Brain Res. 14, 357.
21. Mitchell, J.B. and A. Gratton, 1992, Partial dopamine depletion of the prefrontal cortex leads to enhanced mesolimbic dopamine release elicited by repeated exposure to naturally reinforcing stimuli, J. Neurosci. 12, 3609.
22. Nestler, E.J., 1992, Molecular mechanisms of drug addiction, J. Neurosci. 12, 2439.
23. Nocoń, H., W. Daniel, L. Danek and M. Melzacka, 1990, Cerebral pharmacokinetics of ipsapirone in rats after different routes of administration, J. Pharm. Pharmacol. 42, 642.
24. Olds, M.E., 1990, Enhanced dopamine receptor activation in accumbens and frontal cortex has opposite effects on medial forebrain bundle self-stimulation, Neuroscience 35, 313.
25. Paxinos, G. and C. Watson, 1986, The Rat Brain In Stereotaxic Coordinates, Academic Press, San Diego.
26. 1A /dopamine agonist, J. Pharmacol. Exp. Ther. 268, 1304.
27. Przewłocka, B., A. Sumova and W. Lasoń, 1990, The influence of conditioned fear-induced stress on the opioid systems in the rat, Pharmacol. Biochem. Behav. 37, 661.
28. 1A agonist ±8-OH-DPAT modulates basal and stress-induced changes in medial prefrontal cortical dopamine, Synapse 18, 218.
29. 1A receptor-mediated hyperpolarization of the rat isolated superior cervical ganglion, Naunyn-Schmied. Arch. Pharmacol. 348, 225.
30. 1A receptor agonists block prepulse inhibition of acoustic startle reflex, J. Pharmacol. Exp. Ther. 263, 486.
31. 1A receptors, Brain Res. 532, 191.
32. Söderpalm, B. and J.A. Engel, 1990, Serotonergic involvement in conflict behaviour, Eur. Neuropsychopharmacol. 1, 7.
33. 1A receptor agonist ipsapirone in the rat: neurobiological correlates, Eur. J. Pharmacol. 240, 29.
34. Svensson, L., C. Fahlke, E. Hard and J.A. Engel, 1993, Involvement of the serotonergic system in ethanol intake in the rat, Alcohol 10, 219.
35. Tanda, G., E. Carboni, R. Frau and G. Di Chiara, 1994, Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential?, Psychopharmacology (Berlin) 115, 285.
36. Van Wijngaarden, I., M.T. Tulp and W. Soudijn, 1990, The concept of selectivity in 5-HT receptor research, Eur. J. Pharmacol. 188, 301.
37. Wȩdzony, K. and K. Gołembiowska, 1993, Concomitant administration of MK-801 and desipramine enhances extracellular concentration of dopamine in the rat prefrontal cortex, NeuroReport 5, 75.
38. Wȩdzony, K., K. Gołembiowska and K. Zazula, 1994, Differential effects of CGP 37849 and MK-801, competitive and noncompetitive NMDA antagonists, with respect to the modulation of sensorimotor gating and dopamine outflow in the prefrontal cortex in rats, Naunyn-Schmied. Arch. Pharmacol. 350, 555.
39. Wetzler, S., G.M. Asnis and H.M. Van Praag, 1991, Comment on 5-HT and mechanisms of defence, J. Psychopharmacol. 5, 332.
40. 1A receptor agonist ipsapirone on voluntary alcohol intake in rats, Alcohol 11, 411.