The metallopeptide antibiotic bacitracin inhibits interleukin-12 αβ and β2 secretion

Journal of Pharmacy and Pharmacology

Volumn 57, Issue 2, 2005, Pages 213-218

  Alloza, I ^a   Vandenbroeck, K ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIBIOTIC AGENT; BACITRACIN; INTERLEUKIN 12; INTERLEUKIN 12 ALPHABETA; INTERLEUKIN 12 BETA2; PROTEIN DISULFIDE ISOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG TARGETING; EMBRYO; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; OXIDATION; PROTEIN LOCALIZATION;

ACETYLCYSTEINE; ANIMALS; BACITRACIN; CELL LINE; DRUG EVALUATION, PRECLINICAL; ENDOPLASMIC RETICULUM; HUMANS; INTERLEUKIN-12; METALLOPROTEINS; PROTEIN DISULFIDE-ISOMERASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 12344282701     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357055443     Document Type: Article

References (21)

1. Alloza, I., Martens, E., Hawthorne, S., Vandenbroeck, K. (2004) Crosslinking approach to affinity capture of protein complexes from chaotrope-solubilised cell lysates. Anal. Biochem. 324: 137-142
2. Brombacher, F., Kastelein, R. A., Alber, G. (2003) Novel IL-12 family members shed light on the orchestration of Th1 responses. Trends Immunol. 24: 207-212
3. Davis, C. H., Raulston, J. E., Wyrick, P. B. (2002) Protein disulfide isomerase, a component of the estrogen receptor complex, is associated with Chlamydia trachomatis Serovar E attached to human endometrial epithelial cells. Infect. Immun. 70: 3413-3418
4. Freedman, R. B., Hirst, T. R., Tuite, M. F. (1994) Protein disulfide isomerase: building bridges in protein folding. Trends Biochem. Sci. 19: 331-336
5. Gately, M. K., Carvajal, D. M., Connaughton, S. E., Gillessen, S., Warrier, R. R., Kolinsky, K. D., Wilkinson, V. L., Dwyer, C. M., Higgins, G. F., Frank, J. R., Podlaski, F. J., Faherty, D. A., Familletti, P. C., Stern, A. S., Presky, D. H. (1996) Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo. Ann. N. Y. Acad. Sci. 795: 1-12
6. Gillesen, S., Carvajal, D., Ling, P., Podlaski, F. J., Stremlo, D. L., Familletti, P. C., Gubler, U., Presky, D. H., Stern, A. S., Gately, M. K. (1995). Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 25: 200-206
7. Higuchi, T., Watanabe, Y., Waga, I. (2004) Protein disulfide isomerase suppresses the transcriptional activity of NF-κB. Biochem. Biophys. Res. Commun. 318: 46-52
8. Hong, K., Chu, A., Ludviksson, B. R., Berg, E. L., Ehrhardt, R. O. (1999) IL-12, independently of IFN-gamma, plays a role in the pathogenesis of a murine psoriasis-like skin disorder. J. Immunol. 162: 7480-7491
9. Jones, D. S. (2002) Pharmaceutical statistics. Pharmaceutical Press, London
10. Mandel, R., Ryser, H. J. P., Ghani, F., Wu, M., Peak, D. (1993) Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfide-isomerase. Proc. Natl Acad. Sci. USA 90: 4112-4116
11. Martens, E., Alloza, I., Scott, C. J., Billiau, A., Vandenbroeck, K. (2000) Protein disulfide isomerase-mediated cell-free assembly of recombinant interleukin-12 p40 homodimers. Eur. J. Biochem. 267: 6679-6683
12. Mazzeo, D., Sacco, S., Di Lucia, P., Penna, G., Adorini, L., Panina-Bordignon, P., Ghezzi, P. (2002) Thiol antioxidants inhibit the formation of the interleukin-12 heterodimer: a novel mechanism for the inhibition of IL-12 production. Cytokine 17: 285-293
13. Ming, L. J., Epperson, J. D. (2002) Metal binding and structure-activity relationship of the metalloantibiotic peptide bacitracin. J. Inorg. Biochem. 91: 46-58
14. Mizunaga, T., Katakura, Y., Miura, T., Maruyama, Y. (1990) Purification and characterization of yeast protein disulfide isomerase. J. Biochem. 108: 846-851
15. Primm, T. P., Gilbert, H. F. (2001) Hormone binding by protein disulfide isomerase, a high capacity hormone reservoir of the endoplasmic reticulum. J. Biol. Chem. 276: 281-286
16. Russell, T. D., Yan, Q. Y., Fan, G. S., Khalifah, A. P., Bishop, D. K., Brody, S. L., Walter, M. A. (2003) IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1. J. Immmunol. 171: 6866-6874
17. Vandenbroeck, K., Alloza, I., Brehmer, D., Billiau, A., Proost, P., McFerran, N., Rüdiger, S., Walker, B. (2002) The conserved helix C region in the superfamily of interferon-γ/interleukin-10-related cytokines corresponds to a high-affinity binding site for the HSP70 chaperone DnaK. J. Biol. Chem. 277: 25668-25676
18. Vandenbroeck, K., Alloza, I., Gadina, M., Matthys, P. (2004) Inhibiting cytokines of the interleukin-12 family: recent advances and novel challenges. J. Pharm. Pharmacol. 56: 145-160
19. Wang, C. C., Tsou, C. L. (1993) Protein disulfide-isomerase is both an enzyme and a chaperone. J. Biol. Chem. 7: 1515-1517
20. 2. EMBO J. 16: 651-658
21. Yoon, C., Johnston, S. C., Tang, J., Stahl, M., Tobin, J. F., Somers, W. S. (2000) Charged residues dominate a unique inter-locking topography in the heterodimeric cytokine interleukin-12. EMBO J. 19: 3530-3541