A possible role for the Alzheimer amyloid precursor protein in the regulation of epidermal basal cell proliferation

European Journal of Cell Biology

Volumn 79, Issue 12, 2000, Pages 905-914

  Hoffmann, Jens ^a   Twiesselmann, Christiane ^a   Kummer, Markus P ^a   Romagnoli, Paolo ^b   Herzog, Volker ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Dipartimento Anatomia Umana E Istologia Sezione Istologia E Allara   (Italy)

Author keywords

Alzheimer amyloid precursor protein; Epidermal growth; Keratinocytes; Proliferation

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ANTISENSE OLIGONUCLEOTIDE; ISOPROTEIN; MESSENGER RNA; RECOMBINANT PROTEIN;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; AUTOCRINE EFFECT; BASAL CELL; BINDING COMPETITION; BINDING SITE; CELL CULTURE; CELL GROWTH; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; EPIDERMIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; KERATINOCYTE; MESENCHYME; MITOGENICITY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SECRETION;

EID: 0034535750     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-9335-00117     Document Type: Article

References (53)

1. Three clonal types of keratinocytes with different capacities for multiplication
2. Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor alpha and epidermal growth factor
3. Normal keratinization in a spontaneously immortilized aneuploid human keratinocyte cell line
4. Functions of lipid rafts in biological membranes
5. Proteolytic processing and cell biological functions of the amyloid precursor protein
6. Overexpression of transforming growth factor in psoriatic epidermis
7. Cell surface and cytoskeletal changes associated with epidermal stratification and differentiation in organ cultures of embryonic human skin
8. Regulated O-glycosylation of the Alzheimer β-A4 amyloid precursor protein in thyrocytes
9. Localisation and regulated release of Alzheimer amyloid precursor-like protein in thyrocytes
10. Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication
11. Keratinocyte growth factor is required for hair development but not for wound healing
12. Stem cells: The generation and maintenance of cellular diversity
13. Lipid domain structure of the plasma membrane revealed by patching of membrane components
14. Binding and selective detection of the secretory N-terminal domain of the Alzheimer amyloid precursor protein on cell surfaces
15. Do glycolipid microdomains really exist?
16. Differential regulation of pro-inflammatory cytokines during wound healing in normal and glucocorticoid-treated mice
17. Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoter
18. The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: A new view based on whole-mount labelling and lineage analysis
19. Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension
20. Heterogeneity in basal keratinocytes: Morphological and functional correlations
21. Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism
22. Wound healing - Aiming for perfect skin regeneration
23. Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo
24. Neuronal origin of a cerebral amyloid: Neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels
25. Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factor
26. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
27. Cultivation of human epidermal keratinocytes in serum-free growth medium
28. Low density lipoprotein receptor expression on keratinocytes in normal and psoriatic epidermis
29. Neurotrophic and neuroprotective effects of hAPP in transgenic mice
30. Keratinocyte Cytokines
31. Expression of transforming growth factor β2 RNA during murine morphogenesis
32. From differentiation to proliferation: The secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells
33. Growth factors in cutaneous biology and disease
34. Growth regulation of thyrocytes (FRTL-5-cells) by the secreted ectodomain of β-amyloid precursor-like proteins
35. Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein
36. Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts
37. βA4-amyloid protein precursor mRNA isoforms without exon 15 are ubiqitously expressed in rat tissues including brain, but not in neurons
38. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
39. Cell biology of the amyloid β-protein precursor and the mechanism of Alzheimer's disease
40. Functional rafts in cell membranes
41. Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
42. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system
43. Role of the beta-amyloid protein in Alzheimer's disease
44. A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth
45. Keratinocytes and immunological cytokines
46. Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype
47. The secretory ectodomain of the amyloid precursor protein is endocytosed through caveolae
48. Onset of expression of peanut lectin-binding glycoproteins is correlated with stratification of keratinocytes during human epidermal development in vivo and in vitro
49. An optimized protocol for mRNA quantification using nested competitive RT-PCR
50. Identification, biogenesis and localization of precursors of Alzheimer's disease A4 amyloid protein
51. Large induction of keratinocyte growth factor expression in the dermis during wound healing
52. Keratinocyte growth factor: A unique player in epithelial repair processes
53. The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site