MR spectroscopy study of dichloroacetate treatment after ischemic stroke

Neurology

Volumn 55, Issue 9, 2000, Pages 1376-1378

  Graham, Glenn D ^a,b   Barker, P B ^c   Brooks, W M ^a   Morris, D C ^c   Ahmed, W ^a   Bryniarski, E ^a   Hearshen, D O ^c   Sanders, J A ^b   Holshouser, B A ^d   Turkel, C C ^e  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b VA Medical Center   (United States)

^c HENRY FORD HOSPITAL   (United States)

^d LOMA LINDA UNIVERSITY   (United States)

^e Cypros Pharmaceutical Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; CREATINE; DICHLOROACETIC ACID; LACTIC ACID; PLACEBO;

ARTICLE; BRAIN LEVEL; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENERGY METABOLISM; HUMAN; LACTATE BLOOD LEVEL; NEUROPROTECTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL;

EID: 0034649386     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.55.9.1376     Document Type: Article

References (9)

1. Clinical correlates of proton magnetic resonance spectroscopy findings after acute cerebral infarction
2. The pharmacology of dichloroacetate
3. Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats
4. Short-term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders
5. Reduction in spinal cord postischemic lactic acidosis and functional improvement with dichloroacetate
6. Dichloroacetate attenuates neuronal damage in a gerbil model of brain ischemia
7. Protective effect of dichloroacetate in a rat model of forebrain ischemia
8. 1H-MRS in vivo
9. Brain macromolecules: In vivo measurement by proton magnetic resonance spectroscopy