Sphingosine 1-phosphate signaling: Providing cells with a sense of direction

Trends in Cell Biology

Volumn 12, Issue 5, 2002, Pages 236-242

  Spiegel, Sarah ^a   English, Denis ^b   Milstien, Sheldon ^c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b METHODIST RESEARCH INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; G PROTEIN COUPLED RECEPTOR; GUANOSINE TRIPHOSPHATASE; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN CDC42; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; RAC PROTEIN; RECEPTOR S1P1; RECEPTOR S1P2; RECEPTOR S1P3; RECEPTOR SUBUNIT; RHO FACTOR; SPHINGOSINE 1 PHOSPHATE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; CELL MIGRATION; CELL MOTILITY; CELL TYPE; CHEMOTAXIS; ENDOTHELIUM CELL; GENE DISRUPTION; MORPHOGENESIS; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSACTIVATION;

ANIMALS; CELL MOVEMENT; HUMANS; LYSOPHOSPHOLIPIDS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NEOPLASMS; NEOVASCULARIZATION, PHYSIOLOGIC; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SPHINGOSINE; TRANS-ACTIVATION (GENETICS);

EID: 0036569034     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(02)02277-8     Document Type: Review

References (63)

1. Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation
2. Sphingosine 1-phosphate signalling in mammalian cells
3. Functions of a new family of sphingosine-1-phosphate receptors
4. Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids
5. Lysophospholipids-receptor revelations
6. Sphingosine-1-phosphate as a second messenger in cell proliferation induced by PDGF and FCS mitogens
7. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
8. 2+ signalling by G-protein-coupled receptors
9. Divergence in signal transduction pathways of PDGF and EGF receptors: Involvement of sphingosine-1-phosphate in PDGF but not EGF signaling
10. i-coupled orphan receptor edg-1 and intracellular to regulate proliferation and survival
11. An oncogenic role of sphingosine kinase
12. Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction
13. Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells
14. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy
15. Sphingosine-1-phosphate: Signaling inside and out
16. Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis
17. Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogenesis
18. Sphingosine 1-phosphate induces angiogenesis: Its angiogenic action and signaling mechanism in human umbilical vein endothelial cells
19. Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing
20. A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development
21. Gi-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: Possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways
22. Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis
23. Inhibitory regulation of Rac activation, membrane ruffling and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3
24. G proteins and small GTPases: Distant relatives keep in touch
25. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate
26. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
27. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility
28. Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: Potential role in angiogenesis
29. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
30. An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability
31. Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3
32. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
33. Role of PDGF-β and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
34. Sphingosine 1-phosphate: A prototype of a new class of second messengers
35. Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of γ(iα2)-linked rho kinase activity
36. EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration
37. Tethering of the platelet-derived growth factor β receptor to G-protein coupled receptors: A novel platform for integrative signaling by these receptor classes in mammalian cells
38. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities
39. Rho GTPases and the actin cytoskeleton
40. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
41. Cellular functions regulated by Src family kinases
42. The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility
43. Leukocytes navigate by compass: Roles of PI3Kγ and its lipid products
44. A cell's sense of direction
45. Lipid mediators of angiogenesis and the signaling pathways they initiate
46. FAK integrates growth-factor and integrin signals to promote cell migration
47. Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate
48. Src family kinases are required for integrin but not PDGFR signal transduction
49. Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: Role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase
50. Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization
51. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
52. Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration
53. Sphingosine 1-phosphate regulates heat shock protein 27 induction by a p38 MAP kinase-dependent mechanism in aortic smooth muscle cells
54. Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, edg-1 and edg-3
55. Invasion of T-lymphoma cells: Cooperation between Rho family GTPases and lysophospholipid receptor signaling
56. β-arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes
57. Induction of rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) following phosphorylation by the nonreceptor tyrosine kinase Src
58. Akt-mediated phosphorylation of the G protein-coupled receptor edg-1 is required for endothelial cell chemotaxis
59. Involvement of phosphatidylinositide 3′-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis
60. Localization of the G protein βγ complex in living cells during chemotaxis
61. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis
62. Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum
63. CFTR regulates uptake of sphingoid base phosphates and LPA