Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells

British Journal of Pharmacology

Volumn 134, Issue 1, 2001, Pages 6-9

  Alderton, F ^a   Sambi, B ^a   Tate, R ^a   Pyne, N J ^a   Pyne, S ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

G protein; Kinases; Lysophosphatidate; Phosphatidate; Signalling

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PERTUSSIS TOXIN; PHOSPHATIDIC ACID; PROTEIN P42; PROTEIN P44;

ARTICLE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0034854085     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704278     Document Type: Article

References (11)

1. Tethering of the platelet-derived growth factor β receptor to G-protein-coupled receptors: A novel platform for integrative signalling by these receptor classes in mammalian cells
2. G-protein coupled receptor stimulation of the p42/p44 mitogen activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a and 2 in HEK 293 cells
3. Characterization of a novel subtype of human G-protein coupled receptor for lysophosphatidic acid
4. Naturally occurring analogs of lysophosphatic acid elicit different cellular responses through selective activation of multiple receptor subtypes
5. Molecular cloning of a high affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes
6. Ventricular gene zone-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex
7. Mammalian PSP24s (α and β isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems
8. Sphingosine 1-phosphate signalling in mammalian cells
9. The platelet-derived growth factor stimulation of p42/p44 mitogen-activated protein kinase in airway smooth muscle involves a G-protein-mediated tyrosine phosphorylation of Gab1
10. The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras
11. Enhancement of the migration of metastatic human breast cancer cells by phosphatidic acid