A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain

European Journal of Pharmacology

Volumn 458, Issue 3, 2003, Pages 275-282

  Erichsen, Helle Kirstein ^a   Hao, Jing Xia ^b   Xu, Xiao Jun ^b   Blackburn Munro, Gordon ^a  

^a NEUROSEARCH A S   (Denmark)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Allodynia; Antiarrhythmic; Anticonvulsant; Gazelius nerve injury; Hyperalgesia; Spared nerve injury

Indexed keywords

LAMOTRIGINE; LIDOCAINE; MEXILETINE; SODIUM CHANNEL BLOCKING AGENT; TOCAINIDE;

ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTRIC POTENTIAL; HYPERALGESIA; MALE; NEUROPATHIC PAIN; NONHUMAN; PAIN ASSESSMENT; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; SCIATIC NERVE; WITHDRAWAL REFLEX;

ANALGESICS; ANALYSIS OF VARIANCE; ANESTHETICS, LOCAL; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HINDLIMB; LIDOCAINE; MALE; MEXILETINE; NEURALGIA; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TIME FACTORS; TOCAINIDE; TRIAZINES;

EID: 12244265507     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02792-9     Document Type: Article

References (35)

1. Abdi S., Lee D.H., Chung J.M. The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain. Anesth. Analg. 87:1998;1360-1366.
2. Abram S.E., Yaksh T.L. Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat. Anesthesiology. 2:1994;383-391.
3. Arner S., Meyerson B.A. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain. 33:1988;11-24.
4. Backonja M. Anticonvulsants and antiarrthymics in the treatment of neuropathic pain syndromes. Hansson P.T., Fields H.L., Hill R.G. Neuropathic Pain: Pathophysiology and Treatment, Progress in Pain Research and Management. 2001;185-201 IASP Press, Seattle.
5. + channels in pain pathways. Trends Pharmacol. Sci. 22:2001;27-31.
6. Bennett G.J., Xie Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 33:1988;87-107.
7. + currents in rat sensory neurones. Anesthesiology. 94:2001;137-144.
8. Chabal C., Russell L.C., Burchiel K.J. The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas. Pain. 38:1989;333-338.
9. Chaplan S.R., Bach F.W., Shafer S.L., Yaksh T.L. Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats. Anesthesiology. 83:1995;775-785.
10. Clare J.J., Tate S.N., Nobbs M., Romanos M.A. Voltage-gated sodium channels as therapeutic targets. Drug Discov. Today. 5:2000;506-520.
11. Decosterd I., Woolf C.J. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain. 87:2000;149-158.
12. Decosterd I., Buchser E., Gilliard N., Saydoff J., Zurn A.D., Aebischer P. Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain. Pain. 76:1998;159-166.
13. Devor M., Seltzer Z. Pathophysiology of damaged nerves in relation to chronic pain. Wall P.D., Melzack R. Textbook of Pain. 1999;129-164 Churchill Livingstone, London.
14. Devor M., Wall P.D., Catalan N. Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain. 48:1992;261-268.
15. Erichsen H.K., Blackburn-Munro G. Pharmacological characterisation of the spared nerve injury model of neuropathic pain. Pain. 98:2002;151-161.
16. Gazelius B., Cui J.G., Svensson M., Meyerson B., Linderoth B. Photochemically induced ischaemic lesion of the rat sciatic nerve. A novel method providing high incidence of mononeuropathy. NeuroReport. 7:1996;2619-2623.
17. Hao J.X., Yu Y.X., Seiger Å., Wiesenfeld-Hallin Z. Systemic tocainide relieves mechanical hypersensitivity and normalizes the responses of hyperexcitable dorsal horn wide-dynamic-range neurons after transient spinal cord ischemia in rats. Exp. Brain Res. 91:1992;229-235.
18. Hao J.X., Xu I.S., Xu X.J., Wiesenfeld-Hallin Z. Effects of intrathecal morphine, clonidine and baclofen on allodynia after partial sciatic nerve injury in the rat. Acta Anaesthesiol. Scand. 43:1999;1027-1034.
19. Hunter J.C., Gogas K.R., Hedley L.R., Jacobson L.O., Kassotakis L., Thompson J., Fontana D.J. The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. Eur. J. Pharmacol. 324:1997;153-160.
20. Jett M.F., McGuirk J., Waligora D., Hunter J.C. The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization. Pain. 69:1997;161-169.
21. Kim S.H., Chung J.M. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 50:1992;355-363.
22. + currents: quantitative distinction from phenytoin and possible therapeutic implications. Mol. Pharmacol. 51:1997;1077-1083.
23. Kupers R., Yu W., Persson J.K., Xu X.J., Wiesenfeld-Hallin Z. Photochemically-induced ischemia of the rat sciatic nerve produces a dose-dependent and highly reproducible mechanical, heat and cold allodynia, and signs of spontaneous pain. Pain. 76:1998;45-59.
24. Lindstrom P., Lindblom U. The analgesic effect of tocainide in trigeminal neuralgia. Pain. 28:1987;45-50.
25. Mao J., Chen L.L. Systemic lidocaine for neuropathic pain relief. Pain. 87:2000;7-17.
26. McCleane G. 200 mg of lamotrigine has no analgesic effect in neuropathic pain: a randomised, double-blind placebo controlled trial. Pain. 83:1999;105-107.
27. McCleane G. Reply to Jaques Devulder. Pain. 86:2000;211-212.
28. McQuay H.J., Moore R.A., Eccleston C., Morley S., de Williams A.C. Systematic review of outpatient services for chronic pain control. Health Technol. Assess. 1:1997;1-137.
29. 2 and in the chronic hyperalgesia in rats with streptozotocin-induced diabetes. Pain. 63:1995;33-37.
30. Ragsdale D.S., Avoli M. Sodium channels as molecular targets for antiepileptic drugs. Brains Res. Rev. 26:1998;16-28.
31. Waxman S.G. The molecular pathophysiology of pain: abnormal expression of sodium channel genes and its contributions to hyperexcitability of primary sensory neurons. Pain. S6:1999;S133-S140.
32. Woolf C.J., Salter M.W. Neuronal plasticity: increasing the gain in pain. Science. 288:2000;1765-1769.
33. Xu X.J., Hao J.X., Seiger Å., Arner S., Lindblom U., Wiesenfeld-Hallin Z. Systemic mexiletine relieves chronic allodynia like symptoms in rats with ischemic spinal cord injury. Anesth. Analg. 74:1992;649-652.
34. Zimmerman M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110.
35. Zimmerman M. Pathobiology of neuropathic pain. Eur. J. Pharmacol. 429:2001;23-37.