Effects of intrathecal morphine, clonidine and baclofen on allodynia after partial sciatic nerve injury in the rat

Acta Anaesthesiologica Scandinavica

Volumn 43, Issue 10, 1999, Pages 1027-1034

  Hao, Jing Xia ^a   Xu, I S ^a   Xu, X J ^a   Wiesenfeld Hallin, Z ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Allodynia; Analgesia; GABA; Hyperalgesia; Opioids; Pain; Spinal cord

Indexed keywords

BACLOFEN; CLONIDINE; MORPHINE;

ADOLESCENT; ALLODYNIA; ANIMAL MODEL; ARTICLE; DOSE RESPONSE; DRUG EFFECT; INTRATHECAL DRUG ADMINISTRATION; MALE; NERVE INJURY; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; WITHDRAWAL REFLEX;

EID: 0032731949     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.1999.431010.x     Document Type: Article

References (53)

1. Bennett GJ. Neuropathic pain. In: Wall PD, Melzack R (eds.). Textbook of pain. Edinburgh: Churchill Livingstone, 1994: 201-224.
2. Kingery WS. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes. Pain 1997: 73: 123-140.
3. MacFarlane BV, Wright A, O'Callaghan J, Benson HA. Chronic neuropathic pain and its control by drugs. Pharmacol Ther 1997: 75: 1-19.
4. McQuay HJ. Pharmacological treatment of neuralgic and neuropathic pain. Cancer Survey 1988: 7: 141-159.
5. Arnér S, Meyerson BA. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain 1988: 33: 11-23.
6. Arnér S, Meyerson BA. Opioids in neuropathic pain. Pain Digest 1993: 3: 15-22.
7. Lipman AG. Analgesic drugs for neuropathic and sympathetically maintained pain. Clin Geriatr Med 1996: 12: 501-515.
8. Portenoy RK, Foley KM, Inturrisi CE. The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions. Pain 1990: 43: 273-286.
9. Eisenach JC, DuPen SL, Dubois M, Miguel R, Allin D, The Epidural Clonidine Study Group. Epidural clonidine analgesia for intractable cancer pain. Pain 1995: 61: 391-399.
10. Tamsen A, Gordh Jr TE. Epidural clonidine produces analgesia. Lancet 1984: 2: 231-232.
11. Coventry DM, Todd G. Epidural clonidine in lower limb deafferentation pain. Anesth Analg 1989: 69: 424-425.
12. DuPen SL. Epidural clonidine in the management of severe neuropathic pain: a case study. Reg Anesth 1993: 18 (Suppl.): 22.
13. Glynn C, Jamous MA, Teddy PJ, Moore PK, Lloyd JW. The role of spinal noradrenergic system in transmission of pain in patients with spinal cord injury. Lancet 1986: ii: 1249-1250.
14. Glynn C, Dawson D, Sanders R. A double-blind comparison between epidural morphine and epidural clonidine in patients with chronic non-cancer pain. Pain 1988: 34: 123-128.
15. Siddall PJ, Gray M, Rutkowski S, Cousins MJ. Intrathecal morphine and clonidine in the management of spinal cord injury pain: a case report. Pain 1994: 59: 147-148.
16. Castro-Lopes JM, Tavares I, Coimbra A. GABA decreases in the spinal cord dorsal horn after peripheral neurectomy. Brain Res 1993: 620: 287-291.
17. Wiesenfeld-Hallin Z, Aldskogius H, Grant G, Hao J-X, Hökfelt T, Xu X-J. Central inhibitory dysfunction: mechanisms and clinical implications. Behav Brain Sci 1997: 20: 420-425.
18. Yaksh TL. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effect of modulatory receptor systems and excitatory amino acid antagonists. Pain 1989: 37: 111-123.
19. Bennett GJ, Xie Y-K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988: 33: 87-107.
20. Kim SH, Chung JN. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992: 50: 355-363.
21. Seltzer Z, Dubner R, Shir Y. A novel model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 1990: 43: 205-218.
22. Attal N, Chen YL, Kayser V, Guilbaud G. Behavioral evidence that systemic morphine may modulate a phasic pain-related behavior in a rat model of peripheral mononeuropathy. Pain 1991: 47: 65-70.
23. Backonja MM, Niletic G, Miletic V. The effect of continuous morphine analgesia on chronic thermal hyperalgesia due to sciatic constriction injury in rats. Neurosci Lett 1995: 196: 61-64.
24. Bian D, Nichols ML, Ossipov MH, Lai J, Porreca F. Characterization of the anti-allodynic efficacy of morphine in a model of neuropathic pain in rats. Neuroreport 1995: 6: 1981-1984.
25. Kayser V, Desmeules J, Guilbaud G. Systemic clonidine differentially modulates the abnormal reactions to mechanical and thermal stimuli in rats with peripheral mononeuropathy. Pain 1995: 60: 275-286.
26. Lee Y-W, Chaplan SR, Yaksh TL. Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neurosci Lett 1995: 186: 111-114.
27. Leiphart JW, Dills CV, Zikel OM, Kim DL, Levy RM. A comparison of intrathecally administered narcotic and nonnarcotic analgesics for experimental chronic neuropathic pain. J Neurosurg 1995: 82: 595-599.
28. Mao J, Price DD, Mayer DJ. Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain. Pain 1995: 61: 353-364.
29. Neil A, Kayser V, Chen YL, Guilbaud G. Repeated low doses of morphine do not induce tolerance but increase the opioid antinociceptive effects in rats with a peripheral neuropathy. Brain Res 1990: 522: 140-143.
30. Yaksh TL, Pogrel JW, Lee YW, Chaplan SR. Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists. J Pharmacol Exp Ther 1995: 272: 207-214.
31. Yamamoto T, Yaksh TL. Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve. Anesthesiology 1991: 75: 817-826.
32. Dyck PJ, Karnes JL, O'Brien P, Okazaki H, Lais A, Engelstad J. The spatial distribution of fiber loss in diabetic polyneuropathy suggests ischemia. Ann Neurol 1986: 19: 440-449.
33. Hansson S. Segmental median nerve conduction measurements discriminate carpal tunnel syndrome from diabetic polyneuropathy. Muscle Nerve 1995: 18: 445-453.
34. Low PA. Recent advances in the pathogenesis of diabetic neuropathy. Muscle Nerve 1987: 10: 121-128.
35. Sunderland S. The nerve lesion in the carpal tunnel syndrome. J Neurol Neurosurg Psychiatry 1976: 39: 615-626.
36. Gazelius B, Cui J-G, Svensson M, Meyerson B, Linderoth B. Photochemically induced ischaemic lesion of the rat sciatic nerve. A novel method providing high incidence of mononeuropathy. Neuroreport 1996: 7: 2619-2623.
37. Kauppila T, Xu X-J, Yu W, Wiesenfeld-Hallin Z. Dextromethorphan potentiates the anti-allodynic effect of morphine in rats with peripheral neuropathy. Neuroreport 1998: 9: 1071-1074.
38. Kupers R, Yu W, Persson JKE, Xu X-J, Wiesenfeld-Hallin Z. Photochemically-induced ischemia of the rat sciatic nerve produces a dose-dependent and highly reproducible mechanical, heat and cold allodynia, and signs of spontanous pain. Pain 1998: 76: 45-59.
39. Storkson RV, Kjorsvik A, Tjolsen A, Hole K. Lumbar catheterization of the spinal subarachnoid space in the rat. J Neurosci Meth 1996: 65: 167-172.
40. Hao J-X, Xu X-J. Treatment of a chronic allodynia-like response in spinally injured rats: Effects of systemically administered excitatory amino acid receptor antagonists. Pain 1996: 66: 279-285.
41. Abacus Concepts. Statview Reference. Berkeley: Abacus Concepts Inc., 1996.
42. Hao J-X, Shi T-J, Xu IS, Kaupilla T, Xu X-J, Hökfelt T et al. Intrathecal galanin alleviates allodynia-like behaviors in rats after partial peripheral nerve injury. Eur J Neurosci 1999: 11: 427-432.
43. Ma W, Bisby MA. Differential expression of galanin immunoreactivities in the primary sensory neurons following partial and complete sciatic nerve injuries. Neuroscience 1997: 79: 1183-1195.
44. Besse D, Lombard MC, Perrot S, Besson JM. Regulation of opioid binding sties in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: comparison with sciatic nerve section and lumbar dorsal rhizotomy. Neuroscience 1992: 50: 921-933.
45. Zhang X, Bao L, Shi TJ, Ju G, Elde R, Hökfelt T. Down regulation of mu-opioid receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy. Neuroscience 1998: 82: 223-240.
46. Goff JR, Burkey AR, Goff DJ, Jasmin L. Reorganization of the spinal dorsal horn in models of chronic pain - correlation with behavior. Neuroscience 1998: 82: 559-574.
47. Porreca F, Tang Q-B, Bian D, Riedl M, Elde R, Lai J. Spinal cord mu receptor expression in lumbar spinal cord of rats following nerve injury. Brain Res 1998: 795: 197-203.
48. Hao J-X, Yu W, Xu X-J, Wiesenfeld-Hallin Z. Capsaicin-sensitive afferents mediate chronic cold, but not mechanical, allodynia-like behavior in spinally injured rats. Brain Res 1996: 722: 177-180.
49. Leem JW, Willis WD, Weller SC, Chung JM. Differential activation and classification of cutaneous afferents in the rat. J Neurophysiol 1993: 70: 2411-2424.
50. Xu X-J, Puke MJC, Wiesenfeld-Hallin Z. The depressive effect of intrathecal clonidine on the spinal flexor reflex is enhanced after sciatic nerve section in rats. Pain 1992: 51: 145-151.
51. Kauppila T, Kontinen VK, Pertovaara A. Weight bearing of the limb as a confounding factor in assessment of mechanical allodynia in the rat. Pain 1998: 74: 55-59.
52. Cui J-G, Linderoth B, Meyerson BA. Effects of spinal cord stimulation on touch-evoked allodynia involve GABAergic mechanisms. An experimental study in the mononeuropathic rat. Pain 1996: 66: 287-295.
53. Smith GD, Harrison SM, Birch PJ, Elliott PJ, Malcangio M, Bowery NG. Increased sensitivity to the antinociceptive activity of (±)-baclofen in an animal model of chronic neuropathic, but not chronic inflammatory hyperalgesia. Neuropharmacology 1994: 33: 1103-1108.