Differential effects of CTLA-4 substitutions on the binding of human CD80 (B7-1) and CD86 (B7-2)

Journal of Immunology

Volumn 156, Issue 3, 1996, Pages 1047-1054

  Morton, Phillip A ^a,c   Fu, Xin Ting ^a   Stewart, Julie A ^a   Giacoletto, Karen S ^a   White, Stanley L ^a   Leysath, Clinton E ^b   Evans, Robert J ^a   Shieh, Jeng Jong ^b   Karr, Robert W ^a  

^a PFIZER INC   (United States)

^b MONSANTO COMPANY   (United States)

^c Mail Zone AA4C Monsanto/Searle ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HYBRID PROTEIN; RADIOLIGAND;

AMINO ACID SUBSTITUTION; ANTIGEN BINDING; ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING KINETICS; CELL SURFACE; CONTROLLED STUDY; DISSOCIATION CONSTANT; HUMAN; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, DIFFERENTIATION; BIOSENSING TECHNIQUES; CELL LINE; HUMANS; IMMUNOCONJUGATES; KINETICS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RADIOLIGAND ASSAY; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSFECTION;

EID: 0030030181     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Harding, F. A., J G. McArthur, J. A. Gross, D. H Raulet, and J. P. Allison 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T cell clones Nature 356.607.
2. Schwartz, R. H. 1992. Costimulation of T lymphocytes the role of CD28, CTLA-4, and B7/BB1 in IL-2 production and immunotherapy Cell 71:1065.
3. Hansen, J A, P. J. Martin, and R C Nowinski. 1980. Monoclonal antibodies identifying a novel T cell antigen of human lymphocytes. Immunogenetics 10: 247.
4. Jenkins, M. K, P. S. Taylor, S D. Norton, and K. B. Urdahl. 1991. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J. Immunol. 147:2461.
5. Linsley, P S, and J A Ledbetter 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11.191
6. June, C H., J. A Bluestone, L. M Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321
7. Jenkins, M. K. 1994. The ups and downs of T cell costimulation. Immunity 1:443.
8. Aruffo, A, and B Seed. 1987. Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system Proc. Natl. Acad. Sci USA 84:8573.
9. Gross, J. A., T. St. John, and J P. Allison, 1990. The murine homologue of the T lymphocyte antigen CD28: molecular cloning and cell surface expression. J Immunol. 144.3201
10. Clark, G. J., and M J. Dallman. 1992. Identification of a cDNA encoding the rat CD28 homologue. Immunogenetics 35:54.
11. Ledbetter, J A, P. J. Martin, C. E. Spooner, D. Wofsy, T. T Tsu, P. G Beatty, and P. Gladstone 1985. Antibodies to Tp67 and Tp44 augment and sustain proliferative responses of activated T cells. J Immunol. 135.2331.
12. Azuma, M., D. Ito, H. Yagita, K Okumura, J H Phillips, L. L Lanier, and C. Somoza. 1993. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366:76.
13. Freeman, G. J, J. G. Gribben, V A. Boussiotis, J. W. Ng, V. A Restivo, Jr., L. A. Lombard, G. S Gray, and L M. Nadler 1993 Cloning of B7-2 a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262.909.
14. Linsley, P. S., W. Brady, L. Grosmaire, A Aruffo, N K. Damle, and J. A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173 721.
15. Linsley, P. S, J. L. Greene, W. Brady, J. Bajorath, J. A. Ledbetter, and R. Peach 1994 Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1:793.
16. Linsley, P. S., W. Brady, M. Urnes, L S. Grosmaire, N. K. Damle, and J A Ledbetter. 1991. CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med 174:561
17. Walunas, T. L, D. J. Lenschow, C. Y. Bakker, P. S. Linsley, G. J. Freeman, J. M Green, C. B. Thompson, and J. A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation Immunity 1 405.
18. Turka, L. A, P. S. Linsley, H Lin, W. Brady, J. M Leiden, R. Wei, M L Gibson, X. Zhen, S Myrdal, D. Gordon, T. Bailey, S. F. Bolling, and C. B. Thompson. 1992. T cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc. Natl. Acad Sci. USA 89:11102.
19. Lenschow, D. J., Y. Zeng, J. R. Thistlethwaite, A. Montag, W Brady, M G, Gibson, P. S. Linsley, and J. A. Bluestone. 1992. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science 257:789.
20. Harper, K., C. Balzano, E. Rouvier, M. G. Mattei, M. F. Luciani, and P. Goldstein. 1991. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure and chromosomal location. J. Immunol 147.103.
21. Peach, R. J., J. Bajorath, W. Brady, G. Leytze, J. Greene, J. Naemura, and P S. Linsley. 1994. Complementarity determining region 1 (CDR1)-and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1. J. Exp. Med. 180:2049
22. Cross A. H., T. J. Girard, K. S. Giacoletto, R J. Evans, R. M. Kelling, R. F Lin, J L. Trotter, and R. W. Karr 1995 Long-term inhibition of murine experimental autoimmune encephalitis using CTLA-4-Fc supports a key role for CD28 costimulation. J. Clin Invest. 95:2783
23. Karr, R. W., P. K Gregersen, F. Obata, D. Goldberg, J Maccan, C. Alber, and J. Silver 1986. Analysis of DRβ and DQβ chain cDNA clones from a DR7 haplotype. J Immunol 137:2886
24. Freeman, G. J., A. S Freedman, J. M Segil, G. Lee, J. F. Whitman, and L M. Nadler. 1989. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J. Immunol. 143:2714.
25. Ho, S. N., H D. Hunt, R. M. Horton, J. K. Pullen, and L R Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction Gene 77:51
26. Schwartz, A L., S. E. Fridovich, B. B Knowles, and H F. Lodish. 1981. Characterization of the asialoglycoprotein receptor in a continuous hepatoma line. J. Biol. Chem. 256.8878.
27. Karlsson, R., A. Michaelsson, and L. Mattsson 1991. Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system. J. Immunol. Meth. 145:229.
28. Gribben, J. G, G. J Freeman, V. A. Boussiotis, P. Rennert, C. L Jellis, E. Greenfield, M Barber, V. A. Restivo, Jr., X. Ke, G S. Gray, and L M. Nadler. 1995 CTLA4 mediates antigen-specific apoptosis of human T cells Proc. Natl. Acad. Sci USA 92:811.
29. Schneider, H., K. V S. Prasad, S. E. Shoelson, and C. E. Rudd 1995 CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells J. Exp. Med. 181:351.
30. ras. J. Exp Med. 180 1067.
31. Kuchroo, V K., M. P. Das, J. A. Brown, A. M. Ranger, S. S Zamvil, R A. Sobel, H. L Weiner, N Nabivi, and L H. Glimcher 1995 B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.