Correlative immunohistochemical and reverse transcriptase polymerase chain reaction analysis of somatostatin receptor type 2 in neuroendocrine tumors of the lung

Diagnostic Molecular Pathology

Volumn 9, Issue 1, 2000, Pages 47-57

  Papotti, Mauro ^a   Croce, Sabrina ^b   Macrì, Luigia ^b   Funaro, Aola ^b   Pecchioni, Carla ^b   Schindler, Marcus ^b   Bussolati, Gianni ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b NONE

Author keywords

Immunohistochemistry; Lung; Neuroendocrine; Reverse transcriptase polymerase chain reaction; Small cell carcinoma; Somatostatin receptors; Tumors

Indexed keywords

SOMATOSTATIN RECEPTOR;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG TUMOR; MALE; NEUROENDOCRINE TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; CARCINOID TUMOR; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SMALL CELL; CHROMOGRANIN A; CHROMOGRANINS; DNA PRIMERS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; LUNG NEOPLASMS; MALE; MIDDLE AGED; RECEPTORS, SOMATOSTATIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0034090762     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-200003000-00008     Document Type: Article

References (42)

1. Abbona GC, Papotti M, Viberti L, Macrí L, Stella A, Bussolati G. Chromogranin A gene expression in non-small cell lung carcinomas. J Pathol 1998;186:1-6.
2. Berenger N, Moretti JL, Boaziz C, Vigneron N, Morere JF,Breau JL. Somatostatin receptor imaging in small cell lung cancer. Eur J Cancer 1996;32:1429-31.
3. Bussolati G, Gugliotta P, Volante M, Pace M, Papotti M. Retrieved endogenous biotin: a novel marker and potential pitfall in diagnostic immunohistochemistry. Histopathology 1997;31:400-7.
4. Capella C, Heitz PU, Hofler H, Solcia E, Kloppel G. Revised classification of neuroendocrine tumors of the lung, pancreas and gut. Virchows Arch 1995;425:547-60.
5. Chirgwin JM, Przybyla AE, Mac Donald RJ, Rutter W. Isolation of biologically active RNA from sources enriched in ribonuclease. Biochemistry 1979;18:5294-7.
6. Denzler B, Reubi JC. Expression of somatostatin receptors in peritumoral veins of human tumors. Cancer 1999;85:189-98.
7. Fujita T, Yamaji Y, Sato M, Murao K, Takahara J. Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines. Life Sci 1994;55:1797-806.
8. Gu WZ, Schonbrunn A. Coupling specificity between somatostatin receptor sst2A and G proteins: isolation of the receptor-G protein complex with a receptor antibody. Mol Endocrinol 1997;11:527-37.
9. Gussow D, Rein R, Ginjaar I, Hochstenbach F, Seemann G, Kottman A, Ploegh HL. The human beta 2-microglobulin gene: primary structure and definition of the transcriptional unit. J Immunol 1987;139:3132-8.
10. Helboe L, Moller M, Norregaard L, Schiodt M, Stidsen CE. Development of selective antibodies against the human somatostatin receptor subtypes sstl-sst5. Brain Res Mol Brain Res 1997;49: 82-8.
11. Helman IJ, Ahn TG, Levine MA, et al. Molecular cloning and primary structure of human chromogranin A (secretory protein I) cDNA. J Biol Chem 1988;263:11559-63.
12. Hofland LJ, Liu Q, Van Koetsveld PM, et al. Immunohistochemical detection of somatostatin receptor subtypes sst1 and sst2A in human somatostatin receptor positive tumors. J Clin Endocrinol Metab 1999;84:775-80.
13. Hsu SM, Raine L, Fanger H. Use of avidine-peroxidase complex (ABC) in immunoperoxidase techniques: comparison between ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem 1981;29:577-80.
14. Janson ET, Gobi A, Kalkne KM, Oberg K. A comparison between the efficacy of somatostatin receptor scintigraphy and that of in situ hybridization for somatostatin receptor subtype 2 messenger RNA to predict therapeutic outcome in carcinoid patients. Cancer Res 1996;56:2561-5.
15. Janson ET, Stridsberg M, Gobl A, Westlin JE, Oberg K. Determination of somatostatin receptors subtype 2 in carcinoid tumors by immunohistochemical investigation with somatostatin receptor subtype 2 antibodies. Cancer Res 1998;58:2375-8.
16. Kerstens HMJ, Poddighe PJ, Hanselaar AGJM. A novel in situ hybridization signal amplification method based on the deposition of biotinylated tyramine. J Histochem Cytochem 1995;43:347-52.
17. Krisch B, Feindt J, Mentlein R. Immunoelectronmicroscopic analysis of the ligand-induced internalization of the somatostin receptor subtype 2 in cultured human glioma cells. J Histochem Cytochem 1998;46:1233-42.
18. Kumar U, Laird D, Srikant CB, Escher E, Patel YC. Expression of the five somatostatin receptors (SSTR1-5) subtypes in rat pituitary somatotrophes: quantitative analysis by double-label immunofluorescence confocal microscopy. Endocrinology 1997;138:4473-6.
19. Kwok S, Higuchi R. Avoiding false positives with PCR. Nature 1989;339:237-8.
20. Lamberts SWJ, Hofland LJ, Koetsveld PM, Reubi JC, Bruining HA, Bakker WH, Krenning EP. Parallel in vivo and in vitro detection of functional somatostatin receptors in human endocrine pancreatic tumors: consequences with regard to diagnosis, localization and therapy. J Clin Endocrinol Metab 1990;71:566-74.
21. Malavasi F, Funaro A, Bellone G, et al. Functional and molecular characterization by the CB04 monoclonal antibody of a cell surface structure exerting C3-complement receptor activity. J Clin Immunol 1985;5:412-20.
22. Nilsson O, Kolby L, Wängberg B, et al. Comparative studies on the expression of somatostatin receptor subtypes, outcome of octreotide scintigraphy and response to octreotide treatment in patients with carcinoid tumours. Br J Cancer 1998;77:632-7.
23. Pagani A, Forni M, Tonini GP, Papotti M, Bussolati G. Expression of members of the chromogranin family in primary neuroblastomas. Diagn Mol Pathol 1992;1:16-24.
24. Panetta R, Greenwood MT, Warszynska A, et al. Molecular cloning, functional characterization and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28. Mol Pharmacol 1994;45: 417-27.
25. Papotti M, Macrì L, Bussolati G, Reubi JC. Correlative study on neuroendocrine differentiation and presence of somatostatin receptors in breast carcinomas. Int J Cancer 1989;43:365-9.
26. Papotti M, Macrí L, Pagani A, Aloi F, Bussolati G. Quantitation of somatostatin receptor type 2 in neuroendocrine (Merkel cell) carcinoma of the skin by competitive RT-PCR. Endocr Pathol 1999; 10:1-10.
27. Patel YC, Panetta R, Escher E, Greenwood M, Srikant CB. Expression of multiple somatostatin receptor genes in AtT-20 cells: evidence for a novel somatostatin-28 selective receptor subtype. J Biol Chem 1994;269:1506-9.
28. Pearson WR, Lipman DJ. Improved tools for biological sequence comparison. Proc Natl Acad Sci USA 1988;85:2444-8.
29. Reisinger I, Bohuslavtzki KH, Brenner W, et al. Somatostatin receptor scintigraphy in small-cell lung cancer: results of a multicenter study. J Nucl Med 1998;39:224-7.
30. Reubi JC, Kappeler A, Wsaer B, Laissue J, Hipkin RW, Schonbrunn A. Immunohistochemical localization of somatostatin receptors sst2A in human tumors. Am J Pathol 1998;153:233-45.
31. Reubi JC, Maurer R, von Werder K, Torhorst J, Klijin JGM, Lamberts SWJ. Somatostatin receptors in human endocrine tumors. Cancer Res 1987;47:551-8.
32. Reubi JC, Schaer JC, Waser B, Mengod G. Expression and localization of somatostatin receptors SSTR1, SSTR2, SSTR3 messenger RNA in primary human tumors using in situ hybridisation. Cancer Res 1994;54:3455-9.
33. Reubi JC, Waser B, Sheeppard M, Macaulay V. Somatostatin receptors are present in small-cell but not in non-small-cell primary lung carcinomas: relationship to EGF receptors. Int J Cancer 1990; 45:269-74.
34. Schaer JC, Waser B, Mengod G, Reubi JC. Somatostatin receptors subtypes sstl, sst2, sst3 and sst5 expression in human pituitary, gastroentero-pancreatic and mammary tumors: comparison of mRNA analysis with receptor autoradiography. Int J Cancer 1997; 70:530-7.
35. Schindler M, Holloway S, Humphrey PPA, Waldvogel H, Faull RLM, Berger W, Emson PC. Localization of the somatostatin sst2a receptor in human cerebral cortex, hippocampus and cerebellum. Neuroreport 1998;9:521-5.
36. Schindler M, Sellers LA, Humphrey PPA, Emson PC. Immunohistochemical localization of the somatostatin sst2(A) receptor in the rat brain and spinal cord. Neuroscience 1997;76:225-40.
37. Sestini R, Orlando C, Peri A, et al. Quantification of somatostatin receptor type 2 gene expression in neuroblastoma cell lines and primary tumors using competitive reverse transcription-polymerase chain reaction. Clin Cancer Res 1996;2:1757-65.
38. Speel EJM, Saremaslani P, Roth J, Hopman AHN, Komminoth P. Improved mRNA in situ hybridization on formaldehyde-fixed and paraffin-embedded tissue using signal amplification with different haptenized tyramides. Histochem Cell Biol 1998;420:1-7.
39. Taylor JE, Theveniau MA, Bashirzadeh R, Reisine T, Eden PA. Detection of somatostatin receptor subtype 2 (SSTR2) in established tumors and tumor cell lines: evidence for sst2 heterogeneity. Peptides 1994;15:1229-36.
40. Travis WD, Gal AA, Colby TV, Klimstra DS, Falk R, Koss MN. Reproducibility of neuroendocrine lung tumor classification. Hum Pathol 1998;29:272-9.
41. Yamada Y, Post SR, Wang K, Tager H, Bell GI, Seino S. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract and kidney. Biochemistry 1992;89:251-5.
42. Zhang CY, Yokogoshi Y, Yoshimoto K, Fujinaka Y, Matsumoto K, Saito S. Point mutation of the somatostatin receptor 2 gene in the human small cell lung cancer cell line COR-L103. Biochem Biophys Res Commun 1995;210:805-15.