Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic nude mice

Cancer Chemotherapy and Pharmacology

Volumn 55, Issue 2, 2005, Pages 129-135

  Martignoni, Marcella ^a   De Kanter, Ruben ^a   Moscone, Anna ^a   Grossi, Pietro ^a   Monshouwer, Mario ^a  

^a PFIZER INC   (United States)

Author keywords

Athymic nude mice; CD 1 mice; Cytochrome P450; Strain differences; Transporter proteins

Indexed keywords

BIOLOGICAL MARKER; CARBAMAZEPINE; CHLORPROMAZINE; CYTOCHROME P450; DELAVIRDINE; DEXTROMETHORPHAN; DRUG METABOLITE; ERYTHROMYCIN; ETHOXYRESORUFIN; FLUOXETINE; FLUPHENAZINE; GLUCURONIDE; INDINAVIR; KETOCONAZOLE; LANSOPRAZOLE; MESSENGER RNA; MIDAZOLAM; NIFEDIPINE; ORPHENADRINE; PENTOXYRESORUFIN; QUINIDINE; SALMETEROL; SULFAPHENAZOLE; SULFATE; TESTOSTERONE; TOLBUTAMIDE; TRIAZOLAM; UMBELLIFERONE; VERAPAMIL; WARFARIN;

ADRENAL GLAND; ANIMAL TISSUE; ARTICLE; DRUG CONJUGATION; DRUG METABOLISM; DRUG STABILITY; DRUG TRANSPORT; ENZYME ACTIVITY; INTESTINE; KIDNEY; LIVER METABOLISM; LIVER MICROSOME; LIVER SLICE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; OBSERVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION PROFILING; MALE; MICE; MICE, NUDE; MICROSOMES, LIVER; RNA, MESSENGER; SPECIES SPECIFICITY; UMBELLIFERONES;

EID: 12144283204     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-004-0898-7     Document Type: Article

References (23)

1. Ayrton A, Morgan P (2001) Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica 31:469-497
2. Borst P, Schinkel AH (1996) What have we learnt thus far from mice with disrupted P-glycoprotein genes? Eur J Cancer 32A:985-990
3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
4. Busby WF Jr, Ackermann JM, Crespi CL (1999) Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450. Drug Metab Dispos 27:246-249
5. Choudhary D, Jansson I, Schenkman JB, Sarfarazi M, Stoilov I (2003) Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Arch Biochem Biophys 414:91-100
6. Croop JM, Raymond M, Haber D, Devault A, Arceci RJ, Gros P, Housman DE (1989) The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol 9:1346-1350
7. De Kanter R, Monshouwer M, Draaisma AL, De Jager MH, de Graaf IA, Proost JH, Meijer DK, Groothuis GM (2004) Prediction of whole body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon. Xenobiotica 34:229-241
8. Kelland LR (2004) Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development. Eur J Cancer 40:827-836
9. Manzotti C, Audisio RA, Pratesi G (1993) Importance of orthotopic implantation for human tumors as model systems: relevance to metastasis and invasion. Clin Exp Metastasis 11:5-14
10. Martignoni M, Monshouwer M, de Kanter R, Pezzetta D, Moscone A, Grossi P (2004) Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation. Toxicol In Vitro 18:121-128
11. Meredith C, Scott MP, Renwick AB, Price RJ, Lake BG (2003) Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices. Xenobiotica 33:511-527
12. Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y (2003) Impact of drug transporter studies on drug discovery and development. Pharmacol Rev 55:425-461
13. Mochida Y, Taguchi K, Taniguchi S, Tsuneyoshi M, Kuwano H, Tsuzuki T, Kuwano M, Wada M (2003) The role of P-glycoprotein in intestinal tumorigenesis: disruption of mdr1a suppresses polyp formation in Apc(Min/+) mice. Carcinogenesis 24:1219-1224
14. Pan J, Xiang Q, Ball S (2000) Use of a novel real-time quantitative reverse transcription-polymerase chain reaction method to study the effects of cytokines on cytochrome P450 mRNA expression in mouse liver. Drug Metab Dispos 28:709-713
15. Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP, et al (1994) Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502
16. Schinkel AH, Mayer U, Wagenaar E, Mol CA, van Deemter L, Smit JJ, van der Valk MA, Voordouw AC, Spits H, van Tellingen O, Zijlmans JM, Fibbe WE, Borst P (1997) Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci U S A 94:4028-4033
17. Smit JW, Schinkel AH, Weert B, Meijer DK (1998) Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted. Br J Pharmacol 124:416-424
18. Steensma A, Beamand JA, Walters DG, Price RJ, Lake BG (1994) Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slices. Xenobiotica 24:893-907
19. Weaver RJ (2001) Assessment of drug-drug interactions: concepts and approaches. Xenobiotica 31:499-538
20. Xie H, Audette C, Hoffee M, Lambert JM, Blattler WA (2004) Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice. J Pharmacol Exp Ther 308:1073-1082
21. Yamazaki M, Suzuki H, Sugiyama Y (1996) Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharm Res 13:497-513
22. Zhang QY, Dunbar D, Kaminsky LS (2003) Characterization of mouse small intestinal cytochrome P450 expression. Drug Metab Dispos 31:1346-1351
23. Zollner G, Fickert P, Fuchsbichler A, Silbert D, Wagner M, Arbeiter S, Gonzalez FJ, Marschall HU, Zatloukal K, Denk H, Trauner M (2003) Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. J Hepatol 39:480-488